Which bus from Greenville, SC to St. Louis, MO is the cheapest?

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Compare all timetables for the bus from Greenville, SC to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Greenville, SC to St. Louis, MO from various bus operators like Greyhound US or FlixBus for the next days.

today
tomorrow
Monday
$86
Tuesday
$82
Wednesday
$83
Thursday
$87
Friday

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 18h 55m 8:20 PM Greenville, SC Woodruff Rd 2:15 PM St. Louis, MO Gateway Station  Economy $86
FlixBus 24h 55m 9:35 PM Greenville, SC Woodruff Rd 9:30 PM St. Louis, MO Gateway Station  Economy $89
  • Did you know that if you travel from Greenville, SC to St. Louis, MO via Atlanta, GA, you can save more than $16? You can find the corresponding connections below.
    • Greyhound US
      26h 10m
      0
      8:20 PM
      Greenville, SC
      Woodruff Rd
      11:30 PM
      Atlanta, GA
      Garnett Transit Station
      0
      Greyhound US
      Economy
      $21
      • Waiting Time 11h 20m
    • Greyhound US
      11h 40m
      0
      10:50 AM
      Atlanta, GA
      Garnett Transit Station
      9:30 PM
      St. Louis, MO
      Gateway Station
      0
      Greyhound US
      Economy
      $49
    Travel time is 8h 15m longer, but you will save $16

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 25h 20m 2:50 PM Greenville, SC Woodruff Rd 3:10 PM St. Louis, MO Gateway Station  Economy $82
Greyhound US 20h 35m 8:20 PM Greenville, SC Woodruff Rd 3:55 PM St. Louis, MO Gateway Station  Economy $82
FlixBus 24h 55m 9:35 PM Greenville, SC Woodruff Rd 9:30 PM St. Louis, MO Gateway Station  Economy $84
  • Did you know that if you travel from Greenville, SC to St. Louis, MO via Atlanta, GA, you can save more than $12? You can find the corresponding connections below.
    • Greyhound US
      26h 10m
      0
      8:20 PM
      Greenville, SC
      Woodruff Rd
      11:30 PM
      Atlanta, GA
      Garnett Transit Station
      0
      Greyhound US
      Economy
      $21
      • Waiting Time 11h 20m
    • Greyhound US
      11h 40m
      0
      10:50 AM
      Atlanta, GA
      Garnett Transit Station
      9:30 PM
      St. Louis, MO
      Gateway Station
      0
      Greyhound US
      Economy
      $49
    Travel time is 6h 35m longer, but you will save $12

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 14h 0m 8:20 PM Greenville, SC Woodruff Rd 9:20 AM St. Louis, MO Gateway Station  Economy $83
FlixBus 24h 55m 9:35 PM Greenville, SC Woodruff Rd 9:30 PM St. Louis, MO Gateway Station  Economy $86
  • Did you know that if you travel from Greenville, SC to St. Louis, MO via Atlanta, GA, you can save more than $10? You can find the corresponding connections below.
    • Greyhound US
      14h 0m
      0
      8:20 PM
      Greenville, SC
      Woodruff Rd
      11:30 PM
      Atlanta, GA
      Garnett Transit Station
      0
      Greyhound US
      Economy
      $21
      • Waiting Time 0h 29m
    • FlixBus
      10h 21m
      0
      11:59 PM
      Atlanta, GA
      Garnett Transit Station
      9:20 AM
      St. Louis, MO
      Gateway Station
      0
      FlixBus
      Economy
      $52
    Travel time is 1h 0m longer, but you will save $10

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 14h 0m 8:20 PM Greenville, SC Woodruff Rd 9:20 AM St. Louis, MO Gateway Station  Economy $87
FlixBus 24h 55m 9:35 PM Greenville, SC Woodruff Rd 9:30 PM St. Louis, MO Gateway Station  Economy $87
  • Did you know that if you travel from Greenville, SC to St. Louis, MO via Atlanta, GA, you can save more than $14? You can find the corresponding connections below.
    • Greyhound US
      14h 0m
      0
      8:20 PM
      Greenville, SC
      Woodruff Rd
      11:30 PM
      Atlanta, GA
      Garnett Transit Station
      0
      Greyhound US
      Economy
      $21
      • Waiting Time 0h 29m
    • FlixBus
      10h 21m
      0
      11:59 PM
      Atlanta, GA
      Garnett Transit Station
      9:20 AM
      St. Louis, MO
      Gateway Station
      0
      FlixBus
      Economy
      $52
    Travel time is 1h 0m longer, but you will save $14

Best Price Offer: The price for the cheapest bus from Greenville, SC to St. Louis, MO is $77 on 10/21/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Greenville, SC and St. Louis, MO

See here how frequent the connections between Greenville, SC and St. Louis, MO are, during different times and days of the week.
Tuesday is the busiest day, with more than 3 daily buses from Greenville, SC to St. Louis, MO. Monday has instead the fewest connections, with only 2 daily coaches between Greenville, SC and St. Louis, MO.
The busiest time of the day is the Evening, with 8 buses from Greenville, SC to St. Louis, MO, while Afternoon sees the fewest connections between Greenville, SC and St. Louis, MO, with 1 offers.

Facts about the bus from Greenville, SC to St. Louis, MO

Compare all providers like Greyhound US and FlixBus that travel 2 times every day by bus from Greenville, SC to St. Louis, MO in one click! Book your bus ticket from Greenville, SC to St. Louis, MO starting from $77!

Cheapest Bus $77
Fastest Bus 13h 0m
Earliest Bus 8:20 PM
Latest Bus 9:35 PM
Daily Bus Routes 2 Ø
Distance 504.7 miles
Bus Companies Greyhound US and FlixBus

Cheapest bus connections from Greenville, SC to St. Louis, MO

Every day, 2 buses from 2 bus companies leave Greenville, SC for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 10/24/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 10/18
Monday 10/19
Tuesday 10/20
Wednesday 10/21
Thursday 10/22
Friday 10/23
Saturday 10/24
Sunday 10/25
Monday 10/26
$86
Tuesday 10/27
$82
Wednesday 10/28
$83
Thursday 10/29
$87
Friday 10/30
Saturday 10/31
Sunday 11/01
Monday 11/02
$90
Tuesday 11/03
Wednesday 11/04
Thursday 11/05
Friday 11/06
Saturday 11/07
Sunday 11/08
Monday 11/09
Tuesday 11/10
Wednesday 11/11
Thursday 11/12
Friday 11/13
Saturday 11/14

The cheapest time to travel from Greenville, SC to St. Louis, MO

See here on which day and which time of the day you can find the cheapest bus ticket from Greenville, SC to St. Louis, MO, for the next 30 days.
With a price starting from $82, Tuesday is the cheapest day for a bus from Greenville, SC to St. Louis, MO. Thursday instead is the most expensive day with prices starting from $87.
Afternoon is the cheapest day time for bus tickets from Greenville, SC to St. Louis, MO, with $82. Evening is the most expensive time of the day with prices starting from $82.

How to save money travelling from Greenville, SC to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Greenville, SC to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Greenville, SC to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Greenville, SC to St. Louis, MO are also emptier.

All bus stations and stops in Greenville, SC and St. Louis, MO

In the map below, you can see where to find all bus stations in Greenville, SC and St. Louis, MO.

Service and Comfort on the bus from Greenville, SC to St. Louis, MO

Want to know which seat classes are available on the buses from Greenville, SC to St. Louis, MO? Or which bus companies serve the route Greenville, SC to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Greenville, SC to St. Louis, MO bus

How much does a Greenville, SC St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $77 and takes 19h 35m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Greenville, SC to St. Louis, MO?

This route is offered by 2 companies with a range of ticket prices between $77 and $89. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Greenville, SC to St. Louis, MO each day?

Every day, the Greenville, SC to St. Louis, MO bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Greenville, SC to St. Louis, MO take?

The fastest bus from Greenville, SC to St. Louis, MO is offered by Greyhound US and takes 13h 0m. Bus tickets for this connection cost $83. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Greenville, SC to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Greenville, SC starts at 8:20 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Greenville, SC to St. Louis, MO?

The latest bus trip departing from Greenville, SC for St. Louis, MO starts at 9:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Greenville, SC St. Louis, MO route?

When traveling by bus from Greenville, SC to St. Louis, MO, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Greenville, SC and St. Louis, MO?

You can check all the direct connections between Greenville, SC and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Greenville, SC to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Greenville, SC St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Greenville, SC St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Greenville, SC to St. Louis, MO on your planned travel date.

How does CheckMyBus find the best bus deals from Greenville, SC to St. Louis, MO?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 2 daily trips between Greenville, SC and St. Louis, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Greenville, SC to St. Louis, MO?

Prices and availability for 2 trips between Greenville, SC and St. Louis, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Greenville, SC to St. Louis, MO

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Greenville, SC and to St. Louis, MO

Here’s an overview of the most popular bus routes to Greenville, SC and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Popular Airport Shuttles to Greenville, SC and to St. Louis, MO
CheckMyBus › Buses in USA › Bus to Greenville, SC › Bus to St. Louis, MO

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