Bus Houston to St. Louis, MO - Compare all Companies

Compare all timetables for the bus from Houston to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Houston to St. Louis, MO from various bus operators like FlixBus, Greyhound US or Valley Transit for the next days.

today

$132

tomorrow

$128

Monday

$123

Tuesday

$109

Wednesday

$104

Thursday

$110

Friday

$108

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	27h 50m	6:55 PM	Houston	Harrisburg Blvd Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$132	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/24/2026 6:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/25/2026 10:45:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 27h 50m
Greyhound US	20h 55m	1:50 AM	Houston	Harrisburg Blvd Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$133	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/24/2026 1:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 10/24/2026 10:45:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 20h 55m
FlixBus	24h 30m	1:45 PM	Houston	SW Agencia Autobuses	2:15 PM	St. Louis, MO	Gateway Station	Economy	$133	A Bus from FlixBus goes from SW Agencia Autobuses, Houston (USA) at 10/24/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/25/2026 2:15:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 24h 30m
FlixBus	29h 10m	5:35 PM	Houston	SW Agencia Autobuses	10:45 PM	St. Louis, MO	Gateway Station	Economy	$133	A Bus from FlixBus goes from SW Agencia Autobuses, Houston (USA) at 10/24/2026 5:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/25/2026 10:45:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 29h 10m
Valley Transit	30h 20m	6:35 AM	Houston	SW Agencia Autobuses	12:55 PM	St. Louis, MO	Gateway Station	Economy	$133	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 10/24/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 10/25/2026 12:55:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 30h 20m

Did you know that if you travel from Houston to St. Louis, MO via Memphis, you can save more than $22? You can find the corresponding connections below.
- FlixBus
  
  20h 30m
  
  0
  
  5:45 PM
  
  Houston
  Downtown Houston
  
  8:15 AM
  
  Memphis
  Airways Transit Center
  
  0
  
  Economy
  
  $73
  
  A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 10/25/2026 5:45:00 PM to Airways Transit Center, Memphis (USA) arriving at 10/26/2026 8:15:00 AM. 50 Economy ticket for $73 per person are available. Travel duration is 14h 30m
- FlixBus
  
  4h 45m
  
  0
  
  9:30 AM
  
  Memphis
  Airways Transit Center
  
  2:15 PM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $37
  
  A Bus from FlixBus goes from Airways Transit Center, Memphis (USA) at 10/26/2026 9:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 10/26/2026 2:15:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 4h 45m
Travel Time is 0h 25m shorter, and you will save $22

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	23h 10m	1:45 PM	Houston	Harrisburg Blvd Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$128	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/25/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/26/2026 12:55:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 23h 10m
Greyhound US	24h 5m	2:10 PM	Houston	Harrisburg Blvd Station	2:15 PM	St. Louis, MO	Gateway Station	Economy	$128	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/25/2026 2:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/26/2026 2:15:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 24h 5m
Valley Transit	30h 20m	6:35 AM	Houston	SW Agencia Autobuses	12:55 PM	St. Louis, MO	Gateway Station	Economy	$128	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 10/25/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 10/26/2026 12:55:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 30h 20m
FlixBus	24h 30m	1:45 PM	Houston	SW Agencia Autobuses	2:15 PM	St. Louis, MO	Gateway Station	Economy	$128	A Bus from FlixBus goes from SW Agencia Autobuses, Houston (USA) at 10/25/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/26/2026 2:15:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 24h 30m
FlixBus	32h 0m	2:45 PM	Houston	SW Agencia Autobuses	10:45 PM	St. Louis, MO	Gateway Station	Economy	$128	A Bus from FlixBus goes from SW Agencia Autobuses, Houston (USA) at 10/25/2026 2:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/26/2026 10:45:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 32h 0m

Did you know that if you travel from Houston to St. Louis, MO via Memphis, you can save more than $24? You can find the corresponding connections below.
- FlixBus
  
  20h 30m
  
  0
  
  5:45 PM
  
  Houston
  Downtown Houston
  
  8:15 AM
  
  Memphis
  Airways Transit Center
  
  0
  
  Economy
  
  $69
  
  A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 10/26/2026 5:45:00 PM to Airways Transit Center, Memphis (USA) arriving at 10/27/2026 8:15:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 14h 30m
- FlixBus
  
  4h 45m
  
  0
  
  9:30 AM
  
  Memphis
  Airways Transit Center
  
  2:15 PM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $35
  
  A Bus from FlixBus goes from Airways Transit Center, Memphis (USA) at 10/27/2026 9:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 10/27/2026 2:15:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 4h 45m
Travel Time is 2h 40m shorter, and you will save $24

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	28h 45m	6:00 PM	Houston	Downtown Houston	10:45 PM	St. Louis, MO	Gateway Station	Economy	$123	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 10/26/2026 6:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/27/2026 10:45:00 PM. 50 Economy ticket for $123 per person are available. Travel duration is 28h 45m
Greyhound US	22h 50m	8:15 AM	Houston	Harrisburg Blvd Station	7:05 AM	St. Louis, MO	Gateway Station	Economy	$124	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/26/2026 8:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 10/27/2026 7:05:00 AM. 50 Economy ticket for $124 per person are available. Travel duration is 22h 50m
Greyhound US	24h 5m	2:10 PM	Houston	Harrisburg Blvd Station	2:15 PM	St. Louis, MO	Gateway Station	Economy	$124	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/26/2026 2:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/27/2026 2:15:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 24h 5m
FlixBus	20h 30m	5:45 PM	Houston	Downtown Houston	2:15 PM	St. Louis, MO	Gateway Station	Economy	$124	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 10/26/2026 5:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/27/2026 2:15:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 20h 30m
Valley Transit	30h 40m	6:35 AM	Houston	SW Agencia Autobuses	1:15 PM	St. Louis, MO	Gateway Station	Economy	$141	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 10/26/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 10/27/2026 1:15:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 30h 40m

Did you know that if you travel from Houston to St. Louis, MO via Memphis, you can save more than $19? You can find the corresponding connections below.
- FlixBus
  
  20h 30m
  
  0
  
  5:45 PM
  
  Houston
  Downtown Houston
  
  8:15 AM
  
  Memphis
  Airways Transit Center
  
  0
  
  Economy
  
  $69
  
  A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 10/26/2026 5:45:00 PM to Airways Transit Center, Memphis (USA) arriving at 10/27/2026 8:15:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 14h 30m
- FlixBus
  
  4h 45m
  
  0
  
  9:30 AM
  
  Memphis
  Airways Transit Center
  
  2:15 PM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $35
  
  A Bus from FlixBus goes from Airways Transit Center, Memphis (USA) at 10/27/2026 9:30:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 10/27/2026 2:15:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 4h 45m
Travel time is the same as the direct connection, but you will save $19

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 55m	1:50 AM	Houston	Harrisburg Blvd Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$109	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/27/2026 1:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 10/27/2026 10:45:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 20h 55m
FlixBus	28h 45m	6:00 PM	Houston	Downtown Houston	10:45 PM	St. Louis, MO	Gateway Station	Economy	$110	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 10/27/2026 6:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/28/2026 10:45:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 28h 45m
Greyhound US	27h 50m	6:55 PM	Houston	Harrisburg Blvd Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$111	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/27/2026 6:55:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/28/2026 10:45:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 27h 50m
FlixBus	29h 10m	5:35 PM	Houston	SW Agencia Autobuses	10:45 PM	St. Louis, MO	Gateway Station	Economy	$111	A Bus from FlixBus goes from SW Agencia Autobuses, Houston (USA) at 10/27/2026 5:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/28/2026 10:45:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 29h 10m
Valley Transit	30h 20m	6:35 AM	Houston	SW Agencia Autobuses	12:55 PM	St. Louis, MO	Gateway Station	Economy	$116	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 10/27/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 10/28/2026 12:55:00 PM. 50 Economy ticket for $116 per person are available. Travel duration is 30h 20m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 55m	1:50 AM	Houston	Harrisburg Blvd Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$104	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/28/2026 1:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 10/28/2026 10:45:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 20h 55m
Greyhound US	23h 10m	1:45 PM	Houston	Harrisburg Blvd Station	12:55 PM	St. Louis, MO	Gateway Station	Economy	$104	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/28/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/29/2026 12:55:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 23h 10m
FlixBus	29h 10m	5:35 PM	Houston	SW Agencia Autobuses	10:45 PM	St. Louis, MO	Gateway Station	Economy	$104	A Bus from FlixBus goes from SW Agencia Autobuses, Houston (USA) at 10/28/2026 5:35:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/29/2026 10:45:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 29h 10m
FlixBus	29h 55m	7:00 AM	Houston	Downtown Houston	12:55 PM	St. Louis, MO	Gateway Station	Economy	$104	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 10/28/2026 7:00:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 10/29/2026 12:55:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 29h 55m
Valley Transit	30h 20m	6:35 AM	Houston	SW Agencia Autobuses	12:55 PM	St. Louis, MO	Gateway Station	Economy	$106	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 10/28/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 10/29/2026 12:55:00 PM. 50 Economy ticket for $106 per person are available. Travel duration is 30h 20m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	22h 50m	8:15 AM	Houston	Harrisburg Blvd Station	7:05 AM	St. Louis, MO	Gateway Station	Economy	$110	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/29/2026 8:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 10/30/2026 7:05:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 22h 50m
FlixBus	24h 30m	1:45 PM	Houston	SW Agencia Autobuses	2:15 PM	St. Louis, MO	Gateway Station	Economy	$110	A Bus from FlixBus goes from SW Agencia Autobuses, Houston (USA) at 10/29/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/30/2026 2:15:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 24h 30m
FlixBus	20h 30m	5:45 PM	Houston	Downtown Houston	2:15 PM	St. Louis, MO	Gateway Station	Economy	$110	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 10/29/2026 5:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/30/2026 2:15:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 20h 30m
Greyhound US	20h 55m	1:50 AM	Houston	Harrisburg Blvd Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$111	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/29/2026 1:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 10/29/2026 10:45:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 20h 55m
Valley Transit	30h 20m	6:35 AM	Houston	SW Agencia Autobuses	12:55 PM	St. Louis, MO	Gateway Station	Economy	$113	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 10/29/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 10/30/2026 12:55:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 30h 20m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	25h 0m	10:00 PM	Houston	Harrisburg Blvd Station	11:00 PM	St. Louis, MO	Gateway Station	Economy	$108	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/30/2026 10:00:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/31/2026 11:00:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 25h 0m
Greyhound US	20h 55m	1:50 AM	Houston	Harrisburg Blvd Station	10:45 PM	St. Louis, MO	Gateway Station	Economy	$109	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 10/30/2026 1:50:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 10/30/2026 10:45:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 20h 55m
FlixBus	24h 30m	1:45 PM	Houston	SW Agencia Autobuses	2:15 PM	St. Louis, MO	Gateway Station	Economy	$109	A Bus from FlixBus goes from SW Agencia Autobuses, Houston (USA) at 10/30/2026 1:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/31/2026 2:15:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 24h 30m
FlixBus	23h 40m	1:15 PM	Houston	Downtown Houston	12:55 PM	St. Louis, MO	Gateway Station	Economy	$109	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 10/30/2026 1:15:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/31/2026 12:55:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 23h 40m
Valley Transit	30h 20m	6:35 AM	Houston	SW Agencia Autobuses	12:55 PM	St. Louis, MO	Gateway Station	Economy	$110	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 10/30/2026 6:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 10/31/2026 12:55:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 30h 20m

Best Price Offer: The price for the cheapest bus from Houston to St. Louis, MO is $101 on 11/7/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Houston and St. Louis, MO

See here how frequent the connections between Houston and St. Louis, MO are, during different times and days of the week.

Friday is the busiest day, with more than 26 daily buses from Houston to St. Louis, MO. Tuesday has instead the fewest connections, with only 7 daily coaches between Houston and St. Louis, MO.

The busiest time of the day is the Afternoon, with 57 buses from Houston to St. Louis, MO, while Night sees the fewest connections between Houston and St. Louis, MO, with 12 offers.

Facts about the bus from Houston to St. Louis, MO

Compare all providers like FlixBus, Greyhound US and Valley Transit that travel 17 times every day by bus from Houston to St. Louis, MO in one click! Book your bus ticket from Houston to St. Louis, MO starting from $101!

Cheapest Bus	$101
Fastest Bus	20h 30m
Earliest Bus	1:50 AM
Latest Bus	10:00 PM
Daily Bus Routes	17 Ø
Distance	680.5 miles
Bus Companies	FlixBus, Greyhound US and Valley Transit

Cheapest bus connections from Houston to St. Louis, MO

Every day, 17 buses from 3 bus companies leave Houston for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 10/24/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 10/18

Monday 10/19

Tuesday 10/20

Wednesday 10/21

Thursday 10/22

Friday 10/23

Saturday 10/24

$133

Sunday 10/25

$127

Monday 10/26

$123

Tuesday 10/27

$109

Wednesday 10/28

$103

Thursday 10/29

$110

Friday 10/30

$108

Saturday 10/31

$111

Sunday 11/01

Monday 11/02

$115

Tuesday 11/03

$104

Wednesday 11/04

$110

Thursday 11/05

$101

Friday 11/06

$109

Saturday 11/07

$101

Sunday 11/08

$106

Monday 11/09

$110

Tuesday 11/10

$108

Wednesday 11/11

$120

Thursday 11/12

$117

Friday 11/13

$105

Saturday 11/14

The cheapest time to travel from Houston to St. Louis, MO

See here on which day and which time of the day you can find the cheapest bus ticket from Houston to St. Louis, MO, for the next 30 days.

With a price starting from $101, Saturday is the cheapest day for a bus from Houston to St. Louis, MO. Monday instead is the most expensive day with prices starting from $110.

Night is the cheapest day time for bus tickets from Houston to St. Louis, MO, with $101. Evening is the most expensive time of the day with prices starting from $105.

How to save money travelling from Houston to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Houston to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Houston to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Houston to St. Louis, MO are also emptier.

Beloved bus companies from Houston to St. Louis, MO

These are the most booked bus companies between Houston to St. Louis, MO from our users.

Greyhound US from Houston to St. Louis, MO

Here you will find the key facts about the Greyhound US bus route Houston to St. Louis, MO:

Cheapest Price	$104
Fastest Bus	20h 55m
Earliest Bus	1:50 AM
Last Bus	10:00 PM
Daily Connections	8 Ø
Found on	10/21/2026

Valley Transit from Houston to St. Louis, MO

Here you will find the key facts about the Valley Transit bus route Houston to St. Louis, MO:

Cheapest Price	$106
Fastest Bus	30h 20m
Earliest Bus	6:35 AM
Last Bus	6:35 AM
Daily Connections	1 Ø
Found on	10/21/2026

All bus stations and stops in Houston and St. Louis, MO

In the map below, you can see where to find all bus stations in Houston and St. Louis, MO.

Downtown Houston

Gray St 605

Harrisburg Blvd Station

Harrisburg Blvd 7000

Main Street

Main St 2121

Chase Bank

Milam Street 212

Uptown/Upper Kirby

Southwest Fwy 2525

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Gateway Station

S 15th St 430

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Houston to St. Louis, MO? Compare all modes of transports from Houston to St. Louis, MO.

Service and Comfort on the bus from Houston to St. Louis, MO

Want to know which seat classes are available on the buses from Houston to St. Louis, MO? Or which bus companies serve the route Houston to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Houston to St. Louis, MO bus

How much does a Houston St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $101 and takes 29h 55m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Houston to St. Louis, MO?

This route is offered by 3 companies with a range of ticket prices between $101 and $148. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Houston to St. Louis, MO each day?

Every day, the Houston to St. Louis, MO bus route is served by approximately 17 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Houston to St. Louis, MO take?

The fastest bus from Houston to St. Louis, MO is offered by FlixBus and takes 20h 30m. Bus tickets for this connection cost $135. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Houston to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Houston starts at 1:50 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Houston to St. Louis, MO?

The latest bus trip departing from Houston for St. Louis, MO starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Houston St. Louis, MO route?

When traveling by bus from Houston to St. Louis, MO, passengers can travel with FlixBus, Greyhound US and Valley Transit. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Houston and St. Louis, MO?

You can check all the direct connections between Houston and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, Greyhound US and Valley Transit.

What can I take with me on the Houston to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Houston St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Houston St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Houston to St. Louis, MO on your planned travel date.

How does CheckMyBus find the best bus deals from Houston to St. Louis, MO?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 17 daily trips between Houston and St. Louis, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Houston to St. Louis, MO?

Prices and availability for 17 trips between Houston and St. Louis, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Houston to St. Louis, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Houston and to St. Louis, MO

Here’s an overview of the most popular bus routes to Houston and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!