Which bus from Portland, ME to St. Louis, MO is the cheapest?

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Compare all timetables for the bus from Portland, ME to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Portland, ME to St. Louis, MO from various bus operators like FlixBus or Greyhound US for the next days.

today
tomorrow
Saturday
$159
Sunday
$151
Monday
Tuesday
$136
Wednesday

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 32h 46m 11:59 PM Portland, ME City Hall 7:45 AM St. Louis, MO Gateway Station  Economy $159
Greyhound US 34h 30m 1:45 PM Portland, ME City Hall 11:15 PM St. Louis, MO Gateway Station  Economy $172

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 34h 30m 1:45 PM Portland, ME Bus Stop 11:15 PM St. Louis, MO Gateway Station  Economy $151
FlixBus 32h 46m 11:59 PM Portland, ME Bus Stop 7:45 AM St. Louis, MO Gateway Station  Economy $153

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 32h 46m 11:59 PM Portland, ME Bus Stop 7:45 AM St. Louis, MO Gateway Station  Economy $136
Greyhound US 34h 30m 1:45 PM Portland, ME Bus Stop 11:15 PM St. Louis, MO Gateway Station  Economy $190

Best Price Offer: The price for the cheapest bus from Portland, ME to St. Louis, MO is $98 on 9/15/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Portland, ME and St. Louis, MO

See here how frequent the connections between Portland, ME and St. Louis, MO are, during different times and days of the week.
Sunday is the busiest day, with more than 4 daily buses from Portland, ME to St. Louis, MO. Tuesday has instead the fewest connections, with only 2 daily coaches between Portland, ME and St. Louis, MO.
The busiest time of the day is the Afternoon, with 4 buses from Portland, ME to St. Louis, MO, while Afternoon sees the fewest connections between Portland, ME and St. Louis, MO, with 4 offers.

Facts about the bus from Portland, ME to St. Louis, MO

Compare all providers like FlixBus and Greyhound US that travel 2 times every day by bus from Portland, ME to St. Louis, MO in one click! Book your bus ticket from Portland, ME to St. Louis, MO starting from $98!

Cheapest Bus $98
Fastest Bus 31h 46m
Earliest Bus 1:45 PM
Latest Bus 11:59 PM
Daily Bus Routes 2 Ø
Distance 1,090.0 miles
Bus Companies FlixBus and Greyhound US

Cheapest bus connections from Portland, ME to St. Louis, MO

Every day, 2 buses from 2 bus companies leave Portland, ME for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 08/27/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 08/23
Monday 08/24
Tuesday 08/25
Wednesday 08/26
Thursday 08/27
Friday 08/28
Saturday 08/29
$159
Sunday 08/30
$155
Monday 08/31
Tuesday 09/01
$136
Wednesday 09/02
Thursday 09/03
Friday 09/04
Saturday 09/05
$129
Sunday 09/06
Monday 09/07
Tuesday 09/08
Wednesday 09/09
Thursday 09/10
Friday 09/11
$125
Saturday 09/12
$124
Sunday 09/13
$119
Monday 09/14
Tuesday 09/15
$98
Wednesday 09/16
Thursday 09/17
Friday 09/18
Saturday 09/19

The cheapest time to travel from Portland, ME to St. Louis, MO

See here on which day and which time of the day you can find the cheapest bus ticket from Portland, ME to St. Louis, MO, for the next 30 days.
With a price starting from $98, Tuesday is the cheapest day for a bus from Portland, ME to St. Louis, MO. Saturday instead is the most expensive day with prices starting from $124.
Evening is the cheapest day time for bus tickets from Portland, ME to St. Louis, MO, with $136. Afternoon is the most expensive time of the day with prices starting from $151.

How to save money travelling from Portland, ME to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Portland, ME to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Portland, ME to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Portland, ME to St. Louis, MO are also emptier.

Beloved bus companies from Portland, ME to St. Louis, MO

These are the most booked bus companies between Portland, ME to St. Louis, MO from our users.

Greyhound US from Portland, ME to St. Louis, MO

Greyhound US

Here you will find the key facts about the Greyhound US bus route Portland, ME to St. Louis, MO:

Cheapest Price $151
Fastest Bus 33h 30m
Earliest Bus 1:45 PM
Last Bus 1:45 PM
Daily Connections 1 Ø
Found on 8/1/2026

FlixBus from Portland, ME to St. Louis, MO

FlixBus

Here you will find the key facts about the FlixBus bus route Portland, ME to St. Louis, MO:

Cheapest Price $136
Fastest Bus 31h 46m
Earliest Bus 11:59 PM
Last Bus 11:59 PM
Daily Connections 1 Ø
Found on 8/1/2026

All bus stations and stops in Portland, ME and St. Louis, MO

In the map below, you can see where to find all bus stations in Portland, ME and St. Louis, MO.

Service and Comfort on the bus from Portland, ME to St. Louis, MO

Want to know which seat classes are available on the buses from Portland, ME to St. Louis, MO? Or which bus companies serve the route Portland, ME to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Portland, ME to St. Louis, MO bus

How much does a Portland, ME St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $98 and takes 31h 46m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Portland, ME to St. Louis, MO?

This route is offered by 2 companies with a range of ticket prices between $98 and $190. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Portland, ME to St. Louis, MO each day?

Every day, the Portland, ME to St. Louis, MO bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Portland, ME to St. Louis, MO take?

The fastest bus from Portland, ME to St. Louis, MO is offered by FlixBus and takes 31h 46m. Bus tickets for this connection cost $159. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Portland, ME to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Portland, ME starts at 1:45 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Portland, ME to St. Louis, MO?

The latest bus trip departing from Portland, ME for St. Louis, MO starts at 11:59 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Portland, ME St. Louis, MO route?

When traveling by bus from Portland, ME to St. Louis, MO, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Portland, ME and St. Louis, MO?

You can check all the direct connections between Portland, ME and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Portland, ME to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Portland, ME St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Portland, ME St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Portland, ME to St. Louis, MO on your planned travel date.

How does CheckMyBus find the best bus deals from Portland, ME to St. Louis, MO?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 2 daily trips between Portland, ME and St. Louis, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Portland, ME to St. Louis, MO?

Prices and availability for 2 trips between Portland, ME and St. Louis, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Portland, ME to St. Louis, MO

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Portland, ME and to St. Louis, MO

Here’s an overview of the most popular bus routes to Portland, ME and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Popular Airport Shuttles to Portland, ME and to St. Louis, MO
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