Bus Myrtle Beach, SC to St. Louis, MO

Compare all timetables for the bus from Myrtle Beach, SC to St. Louis, MO

Here is a selection of the cheapest bus trips from the schedule from Myrtle Beach, SC to St. Louis, MO from various bus operators like Greyhound US for the next days.

today

$97

tomorrow

$100

Sunday

$100

Monday

$94

Tuesday

Wednesday

$100

Thursday

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	21h 40m	12:40 PM	Myrtle Beach, SC	Bus Stop	9:20 AM	St. Louis, MO	Gateway Station		Economy	$97	A Bus from Greyhound US goes from Bus Stop, Myrtle Beach, SC (USA) at 10/23/2026 12:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/24/2026 9:20:00 AM. 50 Economy ticket for $97 per person are available. Travel duration is 21h 40m
	Greyhound US	28h 10m	12:45 PM	Myrtle Beach, SC	Bus Stop	3:55 PM	St. Louis, MO	Gateway Station		Economy	$97	A Bus from Greyhound US goes from Bus Stop, Myrtle Beach, SC (USA) at 10/23/2026 12:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/24/2026 3:55:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 28h 10m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 40m	12:40 PM	Myrtle Beach, SC	Bus Stop	9:20 AM	St. Louis, MO	Gateway Station	Economy	$100	A Bus from Greyhound US goes from Bus Stop, Myrtle Beach, SC (USA) at 10/24/2026 12:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/25/2026 9:20:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 21h 40m
Greyhound US	29h 25m	5:05 PM	Myrtle Beach, SC	Bus Stop	9:30 PM	St. Louis, MO	Gateway Station	Economy	$100	A Bus from Greyhound US goes from Bus Stop, Myrtle Beach, SC (USA) at 10/24/2026 5:05:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/25/2026 9:30:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 29h 25m
Greyhound US	28h 10m	12:45 PM	Myrtle Beach, SC	Bus Stop	3:55 PM	St. Louis, MO	Gateway Station	Economy	$101	A Bus from Greyhound US goes from Bus Stop, Myrtle Beach, SC (USA) at 10/24/2026 12:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/25/2026 3:55:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 28h 10m

Did you know that if you travel from Myrtle Beach, SC to St. Louis, MO via Atlanta, GA, you can save more than $11? You can find the corresponding connections below.
- Greyhound US
  
  21h 40m
  
  0
  
  12:40 PM
  
  Myrtle Beach, SC
  Bus Stop
  
  9:35 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $39
  
  A Bus from Greyhound US goes from Bus Stop, Myrtle Beach, SC (USA) at 10/24/2026 12:40:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 10/24/2026 9:35:00 PM. 50 Economy ticket for $39 per person are available. Travel duration is 8h 55m
- FlixBus
  
  10h 21m
  
  0
  
  11:59 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  9:20 AM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $50
  
  A Bus from FlixBus goes from Garnett Transit Station, Atlanta, GA (USA) at 10/24/2026 11:59:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/25/2026 9:20:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 10h 21m
Travel time is 1h 0m longer, but you will save $11

Cheapest bus trips Sunday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	21h 40m	12:40 PM	Myrtle Beach, SC	Bus Stop	9:20 AM	St. Louis, MO	Gateway Station		Economy	$100	A Bus from Greyhound US goes from Bus Stop, Myrtle Beach, SC (USA) at 10/25/2026 12:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/26/2026 9:20:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 21h 40m
	Greyhound US	28h 10m	12:45 PM	Myrtle Beach, SC	Bus Stop	3:55 PM	St. Louis, MO	Gateway Station		Economy	$101	A Bus from Greyhound US goes from Bus Stop, Myrtle Beach, SC (USA) at 10/25/2026 12:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/26/2026 3:55:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 28h 10m

Did you know that if you travel from Myrtle Beach, SC to St. Louis, MO via Atlanta, GA, you can save more than $11? You can find the corresponding connections below.
- Greyhound US
  
  21h 40m
  
  0
  
  12:40 PM
  
  Myrtle Beach, SC
  Bus Stop
  
  9:35 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $39
  
  A Bus from Greyhound US goes from Bus Stop, Myrtle Beach, SC (USA) at 10/24/2026 12:40:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 10/24/2026 9:35:00 PM. 50 Economy ticket for $39 per person are available. Travel duration is 8h 55m
- FlixBus
  
  10h 21m
  
  0
  
  11:59 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  9:20 AM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $50
  
  A Bus from FlixBus goes from Garnett Transit Station, Atlanta, GA (USA) at 10/24/2026 11:59:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/25/2026 9:20:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 10h 21m
Travel time is 1h 0m longer, but you will save $11

Cheapest bus trips Monday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	26h 35m	12:40 PM	Myrtle Beach, SC	Bus Stop	2:15 PM	St. Louis, MO	Gateway Station		Economy	$94	A Bus from Greyhound US goes from Bus Stop, Myrtle Beach, SC (USA) at 10/26/2026 12:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/27/2026 2:15:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 26h 35m
	Greyhound US	28h 10m	12:45 PM	Myrtle Beach, SC	Bus Stop	3:55 PM	St. Louis, MO	Gateway Station		Economy	$96	A Bus from Greyhound US goes from Bus Stop, Myrtle Beach, SC (USA) at 10/26/2026 12:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/27/2026 3:55:00 PM. 50 Economy ticket for $96 per person are available. Travel duration is 28h 10m

Cheapest bus trips Wednesday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	21h 40m	12:40 PM	Myrtle Beach, SC	Bus Stop	9:20 AM	St. Louis, MO	Gateway Station		Economy	$100	A Bus from Greyhound US goes from Bus Stop, Myrtle Beach, SC (USA) at 10/28/2026 12:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/29/2026 9:20:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 21h 40m
	Greyhound US	28h 10m	12:45 PM	Myrtle Beach, SC	Bus Stop	3:55 PM	St. Louis, MO	Gateway Station		Economy	$101	A Bus from Greyhound US goes from Bus Stop, Myrtle Beach, SC (USA) at 10/28/2026 12:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/29/2026 3:55:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 28h 10m

Did you know that if you travel from Myrtle Beach, SC to St. Louis, MO via Atlanta, GA, you can save more than $11? You can find the corresponding connections below.
- Greyhound US
  
  21h 40m
  
  0
  
  12:40 PM
  
  Myrtle Beach, SC
  Bus Stop
  
  9:35 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $39
  
  A Bus from Greyhound US goes from Bus Stop, Myrtle Beach, SC (USA) at 10/24/2026 12:40:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 10/24/2026 9:35:00 PM. 50 Economy ticket for $39 per person are available. Travel duration is 8h 55m
- FlixBus
  
  10h 21m
  
  0
  
  11:59 PM
  
  Atlanta, GA
  Garnett Transit Station
  
  9:20 AM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $50
  
  A Bus from FlixBus goes from Garnett Transit Station, Atlanta, GA (USA) at 10/24/2026 11:59:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 10/25/2026 9:20:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 10h 21m
Travel time is 1h 0m longer, but you will save $11

Best Price Offer: The price for the cheapest bus from Myrtle Beach, SC to St. Louis, MO is $83 on 11/8/2026. Flexible travelers save on ticket prices.

Facts about the bus from Myrtle Beach, SC to St. Louis, MO

Compare all providers like Greyhound US that travel 3 times every day by bus from Myrtle Beach, SC to St. Louis, MO in one click! Book your bus ticket from Myrtle Beach, SC to St. Louis, MO starting from $83!

Cheapest Bus	$83
Fastest Bus	20h 40m
Earliest Bus	12:40 PM
Latest Bus	12:45 PM
Daily Bus Routes	3 Ø
Distance	717.0 miles
Bus Companies	Greyhound US

Cheapest bus connections from Myrtle Beach, SC to St. Louis, MO

Every day, 3 buses from 1 bus companies leave Myrtle Beach, SC for St. Louis, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 10/23/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 10/18

Monday 10/19

Tuesday 10/20

Wednesday 10/21

Thursday 10/22

Friday 10/23

$97

Saturday 10/24

$100

Sunday 10/25

$100

Monday 10/26

$94

Tuesday 10/27

Wednesday 10/28

$100

Thursday 10/29

Friday 10/30

$92

Saturday 10/31

$96

Sunday 11/01

Monday 11/02

$92

Tuesday 11/03

$90

Wednesday 11/04

$98

Thursday 11/05

Friday 11/06

Saturday 11/07

Sunday 11/08

$83

Monday 11/09

$86

Tuesday 11/10

Wednesday 11/11

Thursday 11/12

$100

Friday 11/13

Saturday 11/14

How to save money travelling from Myrtle Beach, SC to St. Louis, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Myrtle Beach, SC to St. Louis, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Myrtle Beach, SC to St. Louis, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Myrtle Beach, SC to St. Louis, MO are also emptier.

All bus stations and stops in Myrtle Beach, SC and St. Louis, MO

In the map below, you can see where to find all bus stations in Myrtle Beach, SC and St. Louis, MO.

Bus Stop

7th Ave N 511

Gateway Station

S 15th St 430

Skinker Boulevard

Boulevard between Lindell Blvd. and Lagoon Drive

Lindbergh @ Hackberry NB Bus Stop

Service and Comfort on the bus from Myrtle Beach, SC to St. Louis, MO

Want to know which seat classes are available on the buses from Myrtle Beach, SC to St. Louis, MO? Or which bus companies serve the route Myrtle Beach, SC to St. Louis, MO? Below you will find answers to your questions.

FAQs about the Myrtle Beach, SC to St. Louis, MO bus

How much does a Myrtle Beach, SC St. Louis, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $83 and takes 25h 35m to reach St. Louis, MO. Compare offers to save money!

How much could I save by comparing buses from Myrtle Beach, SC to St. Louis, MO?

This route is offered by 1 companies with a range of ticket prices between $83 and $105. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to St. Louis, MO.

On average, how many connections are available from Myrtle Beach, SC to St. Louis, MO each day?

Every day, the Myrtle Beach, SC to St. Louis, MO bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Myrtle Beach, SC to St. Louis, MO take?

The fastest bus from Myrtle Beach, SC to St. Louis, MO is offered by Greyhound US and takes 20h 40m. Bus tickets for this connection cost $97. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Myrtle Beach, SC to St. Louis, MO?

The earliest bus arriving in St. Louis, MO from Myrtle Beach, SC starts at 12:40 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Myrtle Beach, SC to St. Louis, MO?

The latest bus trip departing from Myrtle Beach, SC for St. Louis, MO starts at 12:45 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Myrtle Beach, SC St. Louis, MO route?

When traveling by bus from Myrtle Beach, SC to St. Louis, MO, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Myrtle Beach, SC and St. Louis, MO?

You can check all the direct connections between Myrtle Beach, SC and St. Louis, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Myrtle Beach, SC to St. Louis, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Myrtle Beach, SC St. Louis, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Myrtle Beach, SC St. Louis, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Myrtle Beach, SC to St. Louis, MO on your planned travel date.

How does CheckMyBus find the best bus deals from Myrtle Beach, SC to St. Louis, MO?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between Myrtle Beach, SC and St. Louis, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Myrtle Beach, SC to St. Louis, MO?

Prices and availability for 3 trips between Myrtle Beach, SC and St. Louis, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Myrtle Beach, SC to St. Louis, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Myrtle Beach, SC and to St. Louis, MO

Here’s an overview of the most popular bus routes to Myrtle Beach, SC and to St. Louis, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!