Bus Mesa, AZ to San Diego - Compare all Companies

Compare all timetables for the bus from Mesa, AZ to San Diego

Here is a selection of the cheapest bus trips from the schedule from Mesa, AZ to San Diego from various bus operators like Greyhound US for the next days.

today

$54

tomorrow

Saturday

$61

Sunday

$57

Monday

Tuesday

$51

Wednesday

$56

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 30m	7:55 PM	Mesa, AZ	Greyhound	4:25 PM	San Diego	Old Town Transit Center	Economy	$54	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 8/27/2026 7:55:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/28/2026 4:25:00 PM. 50 Economy ticket for $54 per person are available. Travel duration is 20h 30m
Greyhound US	15h 50m	7:55 PM	Mesa, AZ	Greyhound	11:45 AM	San Diego	Old Town Transit Center	Economy	$54	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 8/27/2026 7:55:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/28/2026 11:45:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 15h 50m
Greyhound US	20h 0m	7:55 PM	Mesa, AZ	Greyhound	3:55 PM	San Diego	La Jolla Village	Economy	$59	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 8/27/2026 7:55:00 PM to La Jolla Village, San Diego (USA) arriving at 8/28/2026 3:55:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 20h 0m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	14h 30m	7:55 PM	Mesa, AZ	Greyhound	10:25 AM	San Diego	Seaport Village	Economy	$61	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 8/29/2026 7:55:00 PM to Seaport Village, San Diego (USA) arriving at 8/30/2026 10:25:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 14h 30m
Greyhound US	14h 10m	7:55 PM	Mesa, AZ	Greyhound	10:05 AM	San Diego	Old Town Transit Center	Economy	$61	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 8/29/2026 7:55:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/30/2026 10:05:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 14h 10m
Greyhound US	15h 50m	7:55 PM	Mesa, AZ	Greyhound	11:45 AM	San Diego	Old Town Transit Center	Economy	$63	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 8/29/2026 7:55:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/30/2026 11:45:00 AM. 50 Economy ticket for $63 per person are available. Travel duration is 15h 50m
Greyhound US	22h 25m	7:55 PM	Mesa, AZ	Greyhound	6:20 PM	San Diego	San Ysidro Transit Center	Economy	$63	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 8/29/2026 7:55:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 8/30/2026 6:20:00 PM. 50 Economy ticket for $63 per person are available. Travel duration is 22h 25m
Greyhound US	16h 25m	7:55 PM	Mesa, AZ	Greyhound	12:20 PM	San Diego	San Ysidro Transit Center	Economy	$65	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 8/29/2026 7:55:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 8/30/2026 12:20:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 16h 25m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	15h 50m	7:55 PM	Mesa, AZ	Greyhound	11:45 AM	San Diego	Old Town Transit Center	Economy	$57	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 8/30/2026 7:55:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/31/2026 11:45:00 AM. 50 Economy ticket for $57 per person are available. Travel duration is 15h 50m
Greyhound US	20h 30m	7:55 PM	Mesa, AZ	Greyhound	4:25 PM	San Diego	Old Town Transit Center	Economy	$59	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 8/30/2026 7:55:00 PM to Old Town Transit Center, San Diego (USA) arriving at 8/31/2026 4:25:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 20h 30m
Greyhound US	16h 25m	7:55 PM	Mesa, AZ	Greyhound	12:20 PM	San Diego	San Ysidro Transit Center	Economy	$62	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 8/30/2026 7:55:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 8/31/2026 12:20:00 PM. 50 Economy ticket for $62 per person are available. Travel duration is 16h 25m
Greyhound US	22h 25m	7:55 PM	Mesa, AZ	Greyhound	6:20 PM	San Diego	San Ysidro Transit Center	Economy	$63	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 8/30/2026 7:55:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 8/31/2026 6:20:00 PM. 50 Economy ticket for $63 per person are available. Travel duration is 22h 25m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	15h 50m	7:55 PM	Mesa, AZ	Greyhound	11:45 AM	San Diego	Old Town Transit Center	Economy	$51	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 9/1/2026 7:55:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/2/2026 11:45:00 AM. 50 Economy ticket for $51 per person are available. Travel duration is 15h 50m
Greyhound US	20h 30m	7:55 PM	Mesa, AZ	Greyhound	4:25 PM	San Diego	Old Town Transit Center	Economy	$53	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 9/1/2026 7:55:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/2/2026 4:25:00 PM. 50 Economy ticket for $53 per person are available. Travel duration is 20h 30m
Greyhound US	20h 0m	7:55 PM	Mesa, AZ	Greyhound	3:55 PM	San Diego	La Jolla Village	Economy	$56	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 9/1/2026 7:55:00 PM to La Jolla Village, San Diego (USA) arriving at 9/2/2026 3:55:00 PM. 50 Economy ticket for $56 per person are available. Travel duration is 20h 0m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	15h 50m	7:55 PM	Mesa, AZ	Greyhound	11:45 AM	San Diego	Old Town Transit Center	Economy	$56	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 9/2/2026 7:55:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/3/2026 11:45:00 AM. 50 Economy ticket for $56 per person are available. Travel duration is 15h 50m
Greyhound US	20h 30m	7:55 PM	Mesa, AZ	Greyhound	4:25 PM	San Diego	Old Town Transit Center	Economy	$56	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 9/2/2026 7:55:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/3/2026 4:25:00 PM. 50 Economy ticket for $56 per person are available. Travel duration is 20h 30m
Greyhound US	16h 0m	7:55 PM	Mesa, AZ	Greyhound	11:55 AM	San Diego	Seaport Village	Economy	$60	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 9/2/2026 7:55:00 PM to Seaport Village, San Diego (USA) arriving at 9/3/2026 11:55:00 AM. 50 Economy ticket for $60 per person are available. Travel duration is 16h 0m
Greyhound US	15h 40m	7:55 PM	Mesa, AZ	Greyhound	11:35 AM	San Diego	Old Town Transit Center	Economy	$61	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 9/2/2026 7:55:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/3/2026 11:35:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 15h 40m
Greyhound US	15h 20m	7:55 PM	Mesa, AZ	Greyhound	11:15 AM	San Diego	La Jolla Village	Economy	$61	A Bus from Greyhound US goes from Greyhound, Mesa, AZ (USA) at 9/2/2026 7:55:00 PM to La Jolla Village, San Diego (USA) arriving at 9/3/2026 11:15:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 15h 20m

Best Price Offer: The price for the cheapest bus from Mesa, AZ to San Diego is $51 on 9/1/2026. Flexible travelers save on ticket prices.

Facts about the bus from Mesa, AZ to San Diego

Compare all providers like Greyhound US that travel 6 times every day by bus from Mesa, AZ to San Diego in one click! Book your bus ticket from Mesa, AZ to San Diego starting from $51!

Cheapest Bus	$51
Fastest Bus	13h 45m
Earliest Bus	7:55 PM
Latest Bus	7:55 PM
Daily Bus Routes	6 Ø
Distance	311.8 miles
Bus Companies	Greyhound US

Cheapest bus connections from Mesa, AZ to San Diego

Every day, 6 buses from 1 bus companies leave Mesa, AZ for San Diego: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 08/27/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 08/23

Monday 08/24

Tuesday 08/25

Wednesday 08/26

Thursday 08/27

$58

Friday 08/28

Saturday 08/29

$65

Sunday 08/30

$57

Monday 08/31

Tuesday 09/01

$55

Wednesday 09/02

$56

Thursday 09/03

Friday 09/04

$71

Saturday 09/05

$65

Sunday 09/06

Monday 09/07

Tuesday 09/08

$71

Wednesday 09/09

$67

Thursday 09/10

$60

Friday 09/11

$71

Saturday 09/12

Sunday 09/13

$80

Monday 09/14

$60

Tuesday 09/15

$54

Wednesday 09/16

$63

Thursday 09/17

$63

Friday 09/18

$57

Saturday 09/19

How to save money travelling from Mesa, AZ to San Diego

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Mesa, AZ to San Diego in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Mesa, AZ to San Diego, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Mesa, AZ to San Diego are also emptier.

All bus stations and stops in Mesa, AZ and San Diego

In the map below, you can see where to find all bus stations in Mesa, AZ and San Diego.

Fry’s Fuel Center

W Main Street 1235

Greyhound

S Country Club Dr 1423

Old Town Transit Center

Congress Street 2727

San Ysidro Transit Center

E San Ysidro Blvd 723

Santa Fe Depot

Kettner Blvd 1050

Seaport Village

W Harbor Dr 789

Downtown

Service and Comfort on the bus from Mesa, AZ to San Diego

Want to know which seat classes are available on the buses from Mesa, AZ to San Diego? Or which bus companies serve the route Mesa, AZ to San Diego? Below you will find answers to your questions.

FAQs about the Mesa, AZ to San Diego bus

How much does a Mesa, AZ San Diego bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $51 and takes 15h 50m to reach San Diego. Compare offers to save money!

How much could I save by comparing buses from Mesa, AZ to San Diego?

This route is offered by 1 companies with a range of ticket prices between $51 and $67. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to San Diego.

On average, how many connections are available from Mesa, AZ to San Diego each day?

Every day, the Mesa, AZ to San Diego bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Mesa, AZ to San Diego take?

The fastest bus from Mesa, AZ to San Diego is offered by Greyhound US and takes 13h 45m. Bus tickets for this connection cost $66. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Mesa, AZ to San Diego?

The earliest bus arriving in San Diego from Mesa, AZ starts at 7:55 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Mesa, AZ to San Diego?

The latest bus trip departing from Mesa, AZ for San Diego starts at 7:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Mesa, AZ San Diego route?

When traveling by bus from Mesa, AZ to San Diego, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Mesa, AZ and San Diego?

You can check all the direct connections between Mesa, AZ and San Diego by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Mesa, AZ to San Diego bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Mesa, AZ San Diego bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Mesa, AZ San Diego bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Mesa, AZ to San Diego on your planned travel date.

How does CheckMyBus find the best bus deals from Mesa, AZ to San Diego?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 6 daily trips between Mesa, AZ and San Diego. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Mesa, AZ to San Diego?

Prices and availability for 6 trips between Mesa, AZ and San Diego change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Mesa, AZ to San Diego

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Mesa, AZ and to San Diego

Here’s an overview of the most popular bus routes to Mesa, AZ and to San Diego. Simply click on the connection of your choice, and you will find all the details about your bus route!