Bus San Diego to Chicago: Compare prices and save money

Compare all timetables for the bus from San Diego to Chicago

Here is a selection of the cheapest bus trips from the schedule from San Diego to Chicago from various bus operators like FlixBus or Greyhound US for the next days.

today

tomorrow

$189

Saturday

$167

Sunday

$163

Monday

$154

Tuesday

$178

Wednesday

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	49h 15m	1:10 PM	San Diego	Seaport Village	4:25 PM	Chicago	Downtown Bus Station	Economy	$189	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 10/23/2026 1:10:00 PM to Downtown Bus Station, Chicago (USA) arriving at 10/25/2026 4:25:00 PM. 50 Economy ticket for $189 per person are available. Travel duration is 49h 15m
Greyhound US	50h 40m	11:45 AM	San Diego	Old Town Transit Center	4:25 PM	Chicago	Downtown Bus Station	Economy	$189	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 10/23/2026 11:45:00 AM to Downtown Bus Station, Chicago (USA) arriving at 10/25/2026 4:25:00 PM. 50 Economy ticket for $189 per person are available. Travel duration is 50h 40m
FlixBus	53h 0m	9:25 AM	San Diego	Old Town Transit Center	4:25 PM	Chicago	Downtown Bus Station	Economy	$190	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 10/23/2026 9:25:00 AM to Downtown Bus Station, Chicago (USA) arriving at 10/25/2026 4:25:00 PM. 50 Economy ticket for $190 per person are available. Travel duration is 53h 0m
FlixBus	63h 50m	10:35 PM	San Diego	Old Town Transit Center	4:25 PM	Chicago	Downtown Bus Station	Economy	$190	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 10/23/2026 10:35:00 PM to Downtown Bus Station, Chicago (USA) arriving at 10/26/2026 4:25:00 PM. 50 Economy ticket for $190 per person are available. Travel duration is 63h 50m
Greyhound US	52h 40m	11:45 AM	San Diego	Old Town Transit Center	6:25 PM	Chicago	95th Red Line Station	Economy	$199	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 10/23/2026 11:45:00 AM to 95th Red Line Station, Chicago (USA) arriving at 10/25/2026 6:25:00 PM. 50 Economy ticket for $199 per person are available. Travel duration is 52h 40m

Did you know that if you travel from San Diego to Chicago via Tijuana Airport, you can save more than $19? You can find the corresponding connections below.
- Fronteras del Norte
  
  54h 10m
  
  0
  
  8:15 AM
  
  San Diego
  San Ysidro Transit Center
  
  9:15 AM
  
  Tijuana Airport
  Tijuana Airport
  
  0
  
  Economy
  
  $13
  
  A Bus from Fronteras del Norte goes from San Ysidro Transit Center, San Diego (USA) at 10/25/2026 8:15:00 AM to Tijuana Airport, Tijuana Airport (Mexico) arriving at 10/25/2026 9:15:00 AM. 50 Economy ticket for $13 per person are available. Travel duration is 1h 0m
- Greyhound US
  
  51h 55m
  
  0
  
  10:30 AM
  
  Tijuana Airport
  Tijuana Airport
  
  4:25 PM
  
  Chicago
  Downtown Bus Station
  
  0
  
  Economy
  
  $157
  
  A Bus from Greyhound US goes from Tijuana Airport, Tijuana Airport (Mexico) at 10/25/2026 10:30:00 AM to Downtown Bus Station, Chicago (USA) arriving at 10/27/2026 4:25:00 PM. 50 Economy ticket for $157 per person are available. Travel duration is 51h 55m
Travel time is 2h 55m longer, but you will save $19

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	52h 40m	11:45 AM	San Diego	Old Town Transit Center	6:25 PM	Chicago	95th Red Line Station	Economy	$167	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 10/24/2026 11:45:00 AM to 95th Red Line Station, Chicago (USA) arriving at 10/26/2026 6:25:00 PM. 50 Economy ticket for $167 per person are available. Travel duration is 52h 40m
Greyhound US	55h 25m	7:45 PM	San Diego	Old Town Transit Center	5:10 AM	Chicago	95th Red Line Station	Economy	$167	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 10/24/2026 7:45:00 PM to 95th Red Line Station, Chicago (USA) arriving at 10/27/2026 5:10:00 AM. 50 Economy ticket for $167 per person are available. Travel duration is 55h 25m
FlixBus	51h 15m	1:10 PM	San Diego	Seaport Village	6:25 PM	Chicago	95th Red Line Station	Economy	$168	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 10/24/2026 1:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 10/26/2026 6:25:00 PM. 50 Economy ticket for $168 per person are available. Travel duration is 51h 15m
FlixBus	55h 0m	9:25 AM	San Diego	Old Town Transit Center	6:25 PM	Chicago	95th Red Line Station	Economy	$169	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 10/24/2026 9:25:00 AM to 95th Red Line Station, Chicago (USA) arriving at 10/26/2026 6:25:00 PM. 50 Economy ticket for $169 per person are available. Travel duration is 55h 0m
FlixBus	50h 50m	1:35 PM	San Diego	La Jolla Village	6:25 PM	Chicago	95th Red Line Station	Economy	$172	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 10/24/2026 1:35:00 PM to 95th Red Line Station, Chicago (USA) arriving at 10/26/2026 6:25:00 PM. 50 Economy ticket for $172 per person are available. Travel duration is 50h 50m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	49h 15m	1:10 PM	San Diego	Seaport Village	4:25 PM	Chicago	Downtown Bus Station	Economy	$163	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 10/25/2026 1:10:00 PM to Downtown Bus Station, Chicago (USA) arriving at 10/27/2026 4:25:00 PM. 50 Economy ticket for $163 per person are available. Travel duration is 49h 15m
Greyhound US	50h 40m	11:45 AM	San Diego	Old Town Transit Center	4:25 PM	Chicago	Downtown Bus Station	Economy	$163	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 10/25/2026 11:45:00 AM to Downtown Bus Station, Chicago (USA) arriving at 10/27/2026 4:25:00 PM. 50 Economy ticket for $163 per person are available. Travel duration is 50h 40m
FlixBus	71h 40m	9:25 AM	San Diego	Old Town Transit Center	11:05 AM	Chicago	95th Red Line Station	Economy	$164	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 10/25/2026 9:25:00 AM to 95th Red Line Station, Chicago (USA) arriving at 10/28/2026 11:05:00 AM. 50 Economy ticket for $164 per person are available. Travel duration is 71h 40m
FlixBus	53h 0m	9:25 AM	San Diego	Old Town Transit Center	4:25 PM	Chicago	Downtown Bus Station	Economy	$165	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 10/25/2026 9:25:00 AM to Downtown Bus Station, Chicago (USA) arriving at 10/27/2026 4:25:00 PM. 50 Economy ticket for $165 per person are available. Travel duration is 53h 0m
Greyhound US	54h 35m	7:45 PM	San Diego	Old Town Transit Center	4:20 AM	Chicago	Downtown Bus Station	Economy	$178	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 10/25/2026 7:45:00 PM to Downtown Bus Station, Chicago (USA) arriving at 10/28/2026 4:20:00 AM. 50 Economy ticket for $178 per person are available. Travel duration is 54h 35m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	53h 55m	11:45 AM	San Diego	Old Town Transit Center	7:40 PM	Chicago	95th Red Line Station	Economy	$154	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 10/26/2026 11:45:00 AM to 95th Red Line Station, Chicago (USA) arriving at 10/28/2026 7:40:00 PM. 50 Economy ticket for $154 per person are available. Travel duration is 53h 55m
FlixBus	52h 30m	1:10 PM	San Diego	Seaport Village	7:40 PM	Chicago	95th Red Line Station	Economy	$155	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 10/26/2026 1:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 10/28/2026 7:40:00 PM. 50 Economy ticket for $155 per person are available. Travel duration is 52h 30m
FlixBus	56h 15m	9:25 AM	San Diego	Old Town Transit Center	7:40 PM	Chicago	95th Red Line Station	Economy	$157	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 10/26/2026 9:25:00 AM to 95th Red Line Station, Chicago (USA) arriving at 10/28/2026 7:40:00 PM. 50 Economy ticket for $157 per person are available. Travel duration is 56h 15m
FlixBus	52h 5m	1:35 PM	San Diego	La Jolla Village	7:40 PM	Chicago	95th Red Line Station	Economy	$158	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 10/26/2026 1:35:00 PM to 95th Red Line Station, Chicago (USA) arriving at 10/28/2026 7:40:00 PM. 50 Economy ticket for $158 per person are available. Travel duration is 52h 5m
Greyhound US	50h 40m	11:45 AM	San Diego	Old Town Transit Center	4:25 PM	Chicago	Downtown Bus Station	Economy	$170	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 10/26/2026 11:45:00 AM to Downtown Bus Station, Chicago (USA) arriving at 10/28/2026 4:25:00 PM. 50 Economy ticket for $170 per person are available. Travel duration is 50h 40m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	51h 15m	1:10 PM	San Diego	Seaport Village	6:25 PM	Chicago	95th Red Line Station	Economy	$178	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 10/27/2026 1:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 10/29/2026 6:25:00 PM. 50 Economy ticket for $178 per person are available. Travel duration is 51h 15m
FlixBus	55h 0m	9:25 AM	San Diego	Old Town Transit Center	6:25 PM	Chicago	95th Red Line Station	Economy	$179	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 10/27/2026 9:25:00 AM to 95th Red Line Station, Chicago (USA) arriving at 10/29/2026 6:25:00 PM. 50 Economy ticket for $179 per person are available. Travel duration is 55h 0m
FlixBus	65h 50m	10:35 PM	San Diego	Old Town Transit Center	6:25 PM	Chicago	95th Red Line Station	Economy	$179	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 10/27/2026 10:35:00 PM to 95th Red Line Station, Chicago (USA) arriving at 10/30/2026 6:25:00 PM. 50 Economy ticket for $179 per person are available. Travel duration is 65h 50m
Greyhound US	52h 40m	11:45 AM	San Diego	Old Town Transit Center	6:25 PM	Chicago	95th Red Line Station	Economy	$179	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 10/27/2026 11:45:00 AM to 95th Red Line Station, Chicago (USA) arriving at 10/29/2026 6:25:00 PM. 50 Economy ticket for $179 per person are available. Travel duration is 52h 40m
Greyhound US	55h 25m	7:45 PM	San Diego	Old Town Transit Center	5:10 AM	Chicago	95th Red Line Station	Economy	$180	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 10/27/2026 7:45:00 PM to 95th Red Line Station, Chicago (USA) arriving at 10/30/2026 5:10:00 AM. 50 Economy ticket for $180 per person are available. Travel duration is 55h 25m

Best Price Offer: The price for the cheapest bus from San Diego to Chicago is $136 on 11/8/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between San Diego and Chicago

See here how frequent the connections between San Diego and Chicago are, during different times and days of the week.

Monday is the busiest day, with more than 38 daily buses from San Diego to Chicago. Sunday has instead the fewest connections, with only 15 daily coaches between San Diego and Chicago.

The busiest time of the day is the Evening, with 61 buses from San Diego to Chicago, while Afternoon sees the fewest connections between San Diego and Chicago, with 26 offers.

Facts about the bus from San Diego to Chicago

Compare all providers like FlixBus and Greyhound US that travel 25 times every day by bus from San Diego to Chicago in one click! Book your bus ticket from San Diego to Chicago starting from $136!

Cheapest Bus	$136
Fastest Bus	50h 50m
Earliest Bus	9:25 AM
Latest Bus	10:55 PM
Daily Bus Routes	25 Ø
Distance	1,730.9 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from San Diego to Chicago

Every day, 25 buses from 2 bus companies leave San Diego for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 10/22/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 10/18

Monday 10/19

Tuesday 10/20

Wednesday 10/21

Thursday 10/22

Friday 10/23

$201

Saturday 10/24

$167

Sunday 10/25

$163

Monday 10/26

$158

Tuesday 10/27

$178

Wednesday 10/28

Thursday 10/29

$201

Friday 10/30

$192

Saturday 10/31

Sunday 11/01

Monday 11/02

$147

Tuesday 11/03

$188

Wednesday 11/04

Thursday 11/05

$167

Friday 11/06

$155

Saturday 11/07

$158

Sunday 11/08

$136

Monday 11/09

$154

Tuesday 11/10

$159

Wednesday 11/11

$137

Thursday 11/12

$159

Friday 11/13

Saturday 11/14

The cheapest time to travel from San Diego to Chicago

See here on which day and which time of the day you can find the cheapest bus ticket from San Diego to Chicago, for the next 30 days.

With a price starting from $136, Sunday is the cheapest day for a bus from San Diego to Chicago. Tuesday instead is the most expensive day with prices starting from $159.

Morning is the cheapest day time for bus tickets from San Diego to Chicago, with $154. Evening is the most expensive time of the day with prices starting from $165.

How to save money travelling from San Diego to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Diego to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Diego to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Diego to Chicago are also emptier.

Beloved bus companies from San Diego to Chicago

These are the most booked bus companies between San Diego to Chicago from our users.

Greyhound US from San Diego to Chicago

Here you will find the key facts about the Greyhound US bus route San Diego to Chicago:

Cheapest Price	$154
Fastest Bus	52h 40m
Earliest Bus	9:50 AM
Last Bus	7:45 PM
Daily Connections	7 Ø
Found on	9/27/2026

All bus stations and stops in San Diego and Chicago

In the map below, you can see where to find all bus stations in San Diego and Chicago.

Old Town Transit Center

Congress Street 2727

San Ysidro Transit Center

E San Ysidro Blvd 723

Seaport Village

W Harbor Dr 789

Santa Fe Depot

Kettner Blvd 1050

Downtown

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

W Cermak Rd

W Cermak Rd 1001

Service and Comfort on the bus from San Diego to Chicago

Want to know which seat classes are available on the buses from San Diego to Chicago? Or which bus companies serve the route San Diego to Chicago? Below you will find answers to your questions.

FAQs about the San Diego to Chicago bus

How much does a San Diego Chicago bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $136 and takes 55h 55m to reach Chicago. Compare offers to save money!

How much could I save by comparing buses from San Diego to Chicago?

This route is offered by 2 companies with a range of ticket prices between $136 and $226. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Chicago.

On average, how many connections are available from San Diego to Chicago each day?

Every day, the San Diego to Chicago bus route is served by approximately 25 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Diego to Chicago take?

The fastest bus from San Diego to Chicago is offered by FlixBus and takes 50h 50m. Bus tickets for this connection cost $174. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Diego to Chicago?

The earliest bus arriving in Chicago from San Diego starts at 9:25 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Diego to Chicago?

The latest bus trip departing from San Diego for Chicago starts at 10:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Diego Chicago route?

When traveling by bus from San Diego to Chicago, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Diego and Chicago?

You can check all the direct connections between San Diego and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the San Diego to Chicago bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Diego Chicago bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Diego Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Diego to Chicago on your planned travel date.

How does CheckMyBus find the best bus deals from San Diego to Chicago?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 25 daily trips between San Diego and Chicago. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Diego to Chicago?

Prices and availability for 25 trips between San Diego and Chicago change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Diego to Chicago

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Diego and to Chicago

Here’s an overview of the most popular bus routes to San Diego and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!