Bus Knoxville, TN to San Antonio, TX

Compare all timetables for the bus from Knoxville, TN to San Antonio, TX

Here is a selection of the cheapest bus trips from the schedule from Knoxville, TN to San Antonio, TX from various bus operators like Greyhound US for the next days.

today

$129

tomorrow

$139

Monday

$138

Tuesday

$137

Wednesday

Thursday

$138

Friday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	25h 15m	5:55 PM	Knoxville, TN	Greyhound Bus Station	6:10 PM	San Antonio, TX	Bus Station	Economy	$129	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 10/24/2026 5:55:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/25/2026 6:10:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 25h 15m
Greyhound US	27h 45m	8:00 PM	Knoxville, TN	Greyhound Bus Station	10:45 PM	San Antonio, TX	Bus Station	Economy	$131	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 10/24/2026 8:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/25/2026 10:45:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 27h 45m
Greyhound US	39h 55m	10:00 PM	Knoxville, TN	Greyhound Bus Station	12:55 PM	San Antonio, TX	Bus Station	Economy	$135	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 10/24/2026 10:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/26/2026 12:55:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 39h 55m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	25h 15m	5:55 PM	Knoxville, TN	Greyhound Bus Station	6:10 PM	San Antonio, TX	Bus Station	Economy	$139	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 10/25/2026 5:55:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/26/2026 6:10:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 25h 15m
Greyhound US	39h 55m	10:00 PM	Knoxville, TN	Greyhound Bus Station	12:55 PM	San Antonio, TX	Bus Station	Economy	$140	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 10/25/2026 10:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/27/2026 12:55:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 39h 55m
Greyhound US	27h 45m	8:00 PM	Knoxville, TN	Greyhound Bus Station	10:45 PM	San Antonio, TX	Bus Station	Economy	$148	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 10/25/2026 8:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/26/2026 10:45:00 PM. 50 Economy ticket for $148 per person are available. Travel duration is 27h 45m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	27h 45m	8:00 PM	Knoxville, TN	Greyhound Bus Station	10:45 PM	San Antonio, TX	Bus Station	Economy	$138	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 10/26/2026 8:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/27/2026 10:45:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 27h 45m
Greyhound US	25h 15m	5:55 PM	Knoxville, TN	Greyhound Bus Station	6:10 PM	San Antonio, TX	Bus Station	Economy	$139	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 10/26/2026 5:55:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/27/2026 6:10:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 25h 15m
Greyhound US	39h 55m	10:00 PM	Knoxville, TN	Greyhound Bus Station	12:55 PM	San Antonio, TX	Bus Station	Economy	$142	A Bus from Greyhound US goes from Greyhound Bus Station, Knoxville, TN (USA) at 10/26/2026 10:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/28/2026 12:55:00 PM. 50 Economy ticket for $142 per person are available. Travel duration is 39h 55m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	25h 15m	5:55 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	6:10 PM	San Antonio, TX	Bus Station	Economy	$137	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 10/27/2026 5:55:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/28/2026 6:10:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 25h 15m
Greyhound US	29h 5m	8:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	12:05 AM	San Antonio, TX	Bus Station	Economy	$138	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 10/27/2026 8:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/29/2026 12:05:00 AM. 50 Economy ticket for $138 per person are available. Travel duration is 29h 5m
Greyhound US	39h 55m	10:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	12:55 PM	San Antonio, TX	Bus Station	Economy	$171	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 10/27/2026 10:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/29/2026 12:55:00 PM. 50 Economy ticket for $171 per person are available. Travel duration is 39h 55m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	27h 45m	8:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	10:45 PM	San Antonio, TX	Bus Station	Economy	$138	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 10/29/2026 8:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/30/2026 10:45:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 27h 45m
Greyhound US	25h 15m	5:55 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	6:10 PM	San Antonio, TX	Bus Station	Economy	$139	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 10/29/2026 5:55:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/30/2026 6:10:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 25h 15m
Greyhound US	47h 25m	10:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	8:25 PM	San Antonio, TX	Pearl District	Economy	$143	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 10/29/2026 10:00:00 PM to Pearl District, San Antonio, TX (USA) arriving at 10/31/2026 8:25:00 PM. 50 Economy ticket for $143 per person are available. Travel duration is 47h 25m
Greyhound US	39h 55m	10:00 PM	Knoxville, TN	Knoxville Area Transit Bus Stop	12:55 PM	San Antonio, TX	Bus Station	Economy	$148	A Bus from Greyhound US goes from Knoxville Area Transit Bus Stop, Knoxville, TN (USA) at 10/29/2026 10:00:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/31/2026 12:55:00 PM. 50 Economy ticket for $148 per person are available. Travel duration is 39h 55m

Best Price Offer: The price for the cheapest bus from Knoxville, TN to San Antonio, TX is $103 on 11/5/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Knoxville, TN and San Antonio, TX

See here how frequent the connections between Knoxville, TN and San Antonio, TX are, during different times and days of the week.

Thursday is the busiest day, with more than 8 daily buses from Knoxville, TN to San Antonio, TX. Sunday has instead the fewest connections, with only 3 daily coaches between Knoxville, TN and San Antonio, TX.

The busiest time of the day is the Evening, with 14 buses from Knoxville, TN to San Antonio, TX, while Afternoon sees the fewest connections between Knoxville, TN and San Antonio, TX, with 6 offers.

Facts about the bus from Knoxville, TN to San Antonio, TX

Compare all providers like Greyhound US that travel 4 times every day by bus from Knoxville, TN to San Antonio, TX in one click! Book your bus ticket from Knoxville, TN to San Antonio, TX starting from $103!

Cheapest Bus	$103
Fastest Bus	24h 15m
Earliest Bus	5:55 PM
Latest Bus	10:00 PM
Daily Bus Routes	4 Ø
Distance	958.9 miles
Bus Companies	Greyhound US

Cheapest bus connections from Knoxville, TN to San Antonio, TX

Every day, 4 buses from 1 bus companies leave Knoxville, TN for San Antonio, TX: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 10/24/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 10/18

Monday 10/19

Tuesday 10/20

Wednesday 10/21

Thursday 10/22

Friday 10/23

Saturday 10/24

$129

Sunday 10/25

$139

Monday 10/26

$138

Tuesday 10/27

$137

Wednesday 10/28

Thursday 10/29

$138

Friday 10/30

Saturday 10/31

$132

Sunday 11/01

Monday 11/02

$130

Tuesday 11/03

$129

Wednesday 11/04

Thursday 11/05

$103

Friday 11/06

Saturday 11/07

$108

Sunday 11/08

$118

Monday 11/09

$109

Tuesday 11/10

Wednesday 11/11

Thursday 11/12

$119

Friday 11/13

Saturday 11/14

The cheapest time to travel from Knoxville, TN to San Antonio, TX

See here on which day and which time of the day you can find the cheapest bus ticket from Knoxville, TN to San Antonio, TX, for the next 30 days.

With a price starting from $103, Thursday is the cheapest day for a bus from Knoxville, TN to San Antonio, TX. Tuesday instead is the most expensive day with prices starting from $129.

Afternoon is the cheapest day time for bus tickets from Knoxville, TN to San Antonio, TX, with $129. Evening is the most expensive time of the day with prices starting from $131.

How to save money travelling from Knoxville, TN to San Antonio, TX

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Knoxville, TN to San Antonio, TX in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Knoxville, TN to San Antonio, TX, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Knoxville, TN to San Antonio, TX are also emptier.

Beloved bus companies from Knoxville, TN to San Antonio, TX

These are the most booked bus companies between Knoxville, TN to San Antonio, TX from our users.

Greyhound US from Knoxville, TN to San Antonio, TX

Here you will find the key facts about the Greyhound US bus route Knoxville, TN to San Antonio, TX:

Cheapest Price	$129
Fastest Bus	24h 15m
Earliest Bus	5:55 PM
Last Bus	10:00 PM
Daily Connections	4 Ø
Found on	9/29/2026

All bus stations and stops in Knoxville, TN and San Antonio, TX

In the map below, you can see where to find all bus stations in Knoxville, TN and San Antonio, TX.

Kingston Pike

Kingston Pike 6927

Knoxville Area Transit Bus Stop

Knoxville Area Transit Bus Stop Knoxville Area Transit Bus Stop

Walker Springs Plaza Shopping Center

Kingston Pike 8509

Transit Center

E Church Ave 301

Greyhound Bus Station

E Magnolia Ave 100

Bus Station

N St Mary's St 500

San Antonio

Pearl District

Avenue A 699-599

Commerce & Bowie Bus Stop

W. Southcross & Buffalo Bus Stop

Service and Comfort on the bus from Knoxville, TN to San Antonio, TX

Want to know which seat classes are available on the buses from Knoxville, TN to San Antonio, TX? Or which bus companies serve the route Knoxville, TN to San Antonio, TX? Below you will find answers to your questions.

FAQs about the Knoxville, TN to San Antonio, TX bus

How much does a Knoxville, TN San Antonio, TX bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $103 and takes 24h 15m to reach San Antonio, TX. Compare offers to save money!

How much could I save by comparing buses from Knoxville, TN to San Antonio, TX?

This route is offered by 1 companies with a range of ticket prices between $103 and $171. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to San Antonio, TX.

On average, how many connections are available from Knoxville, TN to San Antonio, TX each day?

Every day, the Knoxville, TN to San Antonio, TX bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Knoxville, TN to San Antonio, TX take?

The fastest bus from Knoxville, TN to San Antonio, TX is offered by Greyhound US and takes 24h 15m. Bus tickets for this connection cost $129. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Knoxville, TN to San Antonio, TX?

The earliest bus arriving in San Antonio, TX from Knoxville, TN starts at 5:55 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Knoxville, TN to San Antonio, TX?

The latest bus trip departing from Knoxville, TN for San Antonio, TX starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Knoxville, TN San Antonio, TX route?

When traveling by bus from Knoxville, TN to San Antonio, TX, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Knoxville, TN and San Antonio, TX?

You can check all the direct connections between Knoxville, TN and San Antonio, TX by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Knoxville, TN to San Antonio, TX bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Knoxville, TN San Antonio, TX bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Knoxville, TN San Antonio, TX bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Knoxville, TN to San Antonio, TX on your planned travel date.

How does CheckMyBus find the best bus deals from Knoxville, TN to San Antonio, TX?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Knoxville, TN and San Antonio, TX. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Knoxville, TN to San Antonio, TX?

Prices and availability for 4 trips between Knoxville, TN and San Antonio, TX change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Knoxville, TN to San Antonio, TX

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Knoxville, TN and to San Antonio, TX

Here’s an overview of the most popular bus routes to Knoxville, TN and to San Antonio, TX. Simply click on the connection of your choice, and you will find all the details about your bus route!