Bus Chicago to San Antonio, TX - Compare all Companies

Compare all timetables for the bus from Chicago to San Antonio, TX

Here is a selection of the cheapest bus trips from the schedule from Chicago to San Antonio, TX from various bus operators like Greyhound US or FlixBus for the next days.

today

$133

tomorrow

Friday

$131

Saturday

$120

Sunday

$101

Monday

$130

Tuesday

$119

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	25h 35m	10:30 PM	Chicago	Downtown Bus Station	12:05 AM	San Antonio, TX	Bus Station	Economy	$133	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 10/21/2026 10:30:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/23/2026 12:05:00 AM. 50 Economy ticket for $133 per person are available. Travel duration is 25h 35m
Greyhound US	32h 15m	9:55 AM	Chicago	Downtown Bus Station	6:10 PM	San Antonio, TX	Bus Station	Economy	$135	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 10/21/2026 9:55:00 AM to Bus Station, San Antonio, TX (USA) arriving at 10/22/2026 6:10:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 32h 15m
Greyhound US	31h 55m	10:15 AM	Chicago	Union Station	6:10 PM	San Antonio, TX	Bus Station	Economy	$135	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 10/21/2026 10:15:00 AM to Bus Station, San Antonio, TX (USA) arriving at 10/22/2026 6:10:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 31h 55m
Greyhound US	45h 35m	10:50 PM	Chicago	Downtown Bus Station	8:25 PM	San Antonio, TX	Pearl District	Economy	$136	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 10/21/2026 10:50:00 PM to Pearl District, San Antonio, TX (USA) arriving at 10/23/2026 8:25:00 PM. 50 Economy ticket for $136 per person are available. Travel duration is 45h 35m
Greyhound US	45h 15m	11:10 PM	Chicago	Union Station	8:25 PM	San Antonio, TX	Pearl District	Economy	$136	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 10/21/2026 11:10:00 PM to Pearl District, San Antonio, TX (USA) arriving at 10/23/2026 8:25:00 PM. 50 Economy ticket for $136 per person are available. Travel duration is 45h 15m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	27h 10m	9:45 AM	Chicago	Downtown Bus Station	12:55 PM	San Antonio, TX	Bus Station	Economy	$131	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 10/23/2026 9:45:00 AM to Bus Station, San Antonio, TX (USA) arriving at 10/24/2026 12:55:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 27h 10m
FlixBus	34h 40m	9:45 AM	Chicago	Downtown Bus Station	8:25 PM	San Antonio, TX	Pearl District	Economy	$132	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 10/23/2026 9:45:00 AM to Pearl District, San Antonio, TX (USA) arriving at 10/24/2026 8:25:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 34h 40m
Greyhound US	32h 15m	9:55 AM	Chicago	Downtown Bus Station	6:10 PM	San Antonio, TX	Bus Station	Economy	$133	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 10/23/2026 9:55:00 AM to Bus Station, San Antonio, TX (USA) arriving at 10/24/2026 6:10:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 32h 15m
Greyhound US	25h 35m	10:30 PM	Chicago	Downtown Bus Station	12:05 AM	San Antonio, TX	Bus Station	Economy	$133	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 10/23/2026 10:30:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/25/2026 12:05:00 AM. 50 Economy ticket for $133 per person are available. Travel duration is 25h 35m
Greyhound US	31h 55m	10:15 AM	Chicago	Union Station	6:10 PM	San Antonio, TX	Bus Station	Economy	$133	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 10/23/2026 10:15:00 AM to Bus Station, San Antonio, TX (USA) arriving at 10/24/2026 6:10:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 31h 55m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	31h 30m	4:35 PM	Chicago	95th Red Line Station	12:05 AM	San Antonio, TX	Bus Station	Economy	$120	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 10/24/2026 4:35:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/26/2026 12:05:00 AM. 50 Economy ticket for $120 per person are available. Travel duration is 31h 30m
FlixBus	38h 40m	5:45 AM	Chicago	95th Red Line Station	8:25 PM	San Antonio, TX	Pearl District	Economy	$120	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 10/24/2026 5:45:00 AM to Pearl District, San Antonio, TX (USA) arriving at 10/25/2026 8:25:00 PM. 50 Economy ticket for $120 per person are available. Travel duration is 38h 40m
FlixBus	48h 25m	11:55 PM	Chicago	95th Red Line Station	12:20 AM	San Antonio, TX	Pearl District	Economy	$120	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 10/24/2026 11:55:00 PM to Pearl District, San Antonio, TX (USA) arriving at 10/27/2026 12:20:00 AM. 50 Economy ticket for $120 per person are available. Travel duration is 48h 25m
Greyhound US	47h 30m	11:40 PM	Chicago	95th Red Line Station	11:10 PM	San Antonio, TX	Pearl District	Economy	$122	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 10/24/2026 11:40:00 PM to Pearl District, San Antonio, TX (USA) arriving at 10/26/2026 11:10:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 47h 30m
Greyhound US	25h 35m	10:30 PM	Chicago	Downtown Bus Station	12:05 AM	San Antonio, TX	Bus Station	Economy	$123	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 10/24/2026 10:30:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/26/2026 12:05:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 25h 35m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	37h 0m	11:55 PM	Chicago	95th Red Line Station	12:55 PM	San Antonio, TX	Bus Station	Economy	$101	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 10/25/2026 11:55:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/27/2026 12:55:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 37h 0m
FlixBus	31h 30m	4:35 PM	Chicago	95th Red Line Station	12:05 AM	San Antonio, TX	Bus Station	Economy	$102	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 10/25/2026 4:35:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/27/2026 12:05:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 31h 30m
FlixBus	41h 25m	5:45 AM	Chicago	95th Red Line Station	11:10 PM	San Antonio, TX	Pearl District	Economy	$105	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 10/25/2026 5:45:00 AM to Pearl District, San Antonio, TX (USA) arriving at 10/26/2026 11:10:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 41h 25m
Greyhound US	29h 30m	11:40 PM	Chicago	95th Red Line Station	5:10 AM	San Antonio, TX	Bus Station	Economy	$117	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 10/25/2026 11:40:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/27/2026 5:10:00 AM. 50 Economy ticket for $117 per person are available. Travel duration is 29h 30m
Greyhound US	32h 15m	9:55 AM	Chicago	Downtown Bus Station	6:10 PM	San Antonio, TX	Bus Station	Economy	$119	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 10/25/2026 9:55:00 AM to Bus Station, San Antonio, TX (USA) arriving at 10/26/2026 6:10:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 32h 15m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	37h 25m	9:45 AM	Chicago	Downtown Bus Station	11:10 PM	San Antonio, TX	Pearl District	Economy	$130	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 10/26/2026 9:45:00 AM to Pearl District, San Antonio, TX (USA) arriving at 10/27/2026 11:10:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 37h 25m
Greyhound US	32h 15m	9:55 AM	Chicago	Downtown Bus Station	6:10 PM	San Antonio, TX	Bus Station	Economy	$130	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 10/26/2026 9:55:00 AM to Bus Station, San Antonio, TX (USA) arriving at 10/27/2026 6:10:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 32h 15m
Greyhound US	25h 35m	10:30 PM	Chicago	Downtown Bus Station	12:05 AM	San Antonio, TX	Bus Station	Economy	$130	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 10/26/2026 10:30:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/28/2026 12:05:00 AM. 50 Economy ticket for $130 per person are available. Travel duration is 25h 35m
Greyhound US	31h 55m	10:15 AM	Chicago	Union Station	6:10 PM	San Antonio, TX	Bus Station	Economy	$130	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 10/26/2026 10:15:00 AM to Bus Station, San Antonio, TX (USA) arriving at 10/27/2026 6:10:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 31h 55m
FlixBus	27h 10m	9:45 AM	Chicago	Downtown Bus Station	12:55 PM	San Antonio, TX	Bus Station	Economy	$131	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 10/26/2026 9:45:00 AM to Bus Station, San Antonio, TX (USA) arriving at 10/27/2026 12:55:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 27h 10m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	30h 45m	6:10 AM	Chicago	Downtown Bus Station	12:55 PM	San Antonio, TX	Bus Station	Economy	$119	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 10/27/2026 6:10:00 AM to Bus Station, San Antonio, TX (USA) arriving at 10/28/2026 12:55:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 30h 45m
Greyhound US	25h 35m	10:30 PM	Chicago	Downtown Bus Station	12:05 AM	San Antonio, TX	Bus Station	Economy	$119	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 10/27/2026 10:30:00 PM to Bus Station, San Antonio, TX (USA) arriving at 10/29/2026 12:05:00 AM. 50 Economy ticket for $119 per person are available. Travel duration is 25h 35m
Greyhound US	32h 15m	9:55 AM	Chicago	Downtown Bus Station	6:10 PM	San Antonio, TX	Bus Station	Economy	$120	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 10/27/2026 9:55:00 AM to Bus Station, San Antonio, TX (USA) arriving at 10/28/2026 6:10:00 PM. 50 Economy ticket for $120 per person are available. Travel duration is 32h 15m
Greyhound US	31h 55m	10:15 AM	Chicago	Union Station	6:10 PM	San Antonio, TX	Bus Station	Economy	$120	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 10/27/2026 10:15:00 AM to Bus Station, San Antonio, TX (USA) arriving at 10/28/2026 6:10:00 PM. 50 Economy ticket for $120 per person are available. Travel duration is 31h 55m

Best Price Offer: The price for the cheapest bus from Chicago to San Antonio, TX is $89 on 11/10/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Chicago and San Antonio, TX

See here how frequent the connections between Chicago and San Antonio, TX are, during different times and days of the week.

Saturday is the busiest day, with more than 16 daily buses from Chicago to San Antonio, TX. Tuesday has instead the fewest connections, with only 4 daily coaches between Chicago and San Antonio, TX.

The busiest time of the day is the Evening, with 29 buses from Chicago to San Antonio, TX, while Afternoon sees the fewest connections between Chicago and San Antonio, TX, with 2 offers.

Facts about the bus from Chicago to San Antonio, TX

Compare all providers like Greyhound US and FlixBus that travel 9 times every day by bus from Chicago to San Antonio, TX in one click! Book your bus ticket from Chicago to San Antonio, TX starting from $89!

Cheapest Bus	$89
Fastest Bus	25h 35m
Earliest Bus	6:10 AM
Latest Bus	10:30 PM
Daily Bus Routes	9 Ø
Distance	1,052.2 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Chicago to San Antonio, TX

Every day, 9 buses from 2 bus companies leave Chicago for San Antonio, TX: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 10/21/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 10/18

Monday 10/19

Tuesday 10/20

Wednesday 10/21

$133

Thursday 10/22

Friday 10/23

$131

Saturday 10/24

$120

Sunday 10/25

$101

Monday 10/26

$130

Tuesday 10/27

$119

Wednesday 10/28

$99

Thursday 10/29

$106

Friday 10/30

$144

Saturday 10/31

$155

Sunday 11/01

Monday 11/02

$131

Tuesday 11/03

$101

Wednesday 11/04

$123

Thursday 11/05

$127

Friday 11/06

Saturday 11/07

$104

Sunday 11/08

$120

Monday 11/09

$106

Tuesday 11/10

$89

Wednesday 11/11

Thursday 11/12

Friday 11/13

Saturday 11/14

The cheapest time to travel from Chicago to San Antonio, TX

See here on which day and which time of the day you can find the cheapest bus ticket from Chicago to San Antonio, TX, for the next 30 days.

With a price starting from $89, Tuesday is the cheapest day for a bus from Chicago to San Antonio, TX. Friday instead is the most expensive day with prices starting from $131.

Night is the cheapest day time for bus tickets from Chicago to San Antonio, TX, with $89. Morning is the most expensive time of the day with prices starting from $119.

How to save money travelling from Chicago to San Antonio, TX

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Chicago to San Antonio, TX in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Chicago to San Antonio, TX, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Chicago to San Antonio, TX are also emptier.

Beloved bus companies from Chicago to San Antonio, TX

These are the most booked bus companies between Chicago to San Antonio, TX from our users.

Greyhound US from Chicago to San Antonio, TX

Here you will find the key facts about the Greyhound US bus route Chicago to San Antonio, TX:

Cheapest Price	$117
Fastest Bus	25h 35m
Earliest Bus	6:10 AM
Last Bus	10:30 PM
Daily Connections	6 Ø
Found on	9/27/2026

FlixBus from Chicago to San Antonio, TX

Here you will find the key facts about the FlixBus bus route Chicago to San Antonio, TX:

Cheapest Price	$101
Fastest Bus	27h 10m
Earliest Bus	9:45 AM
Last Bus	9:45 AM
Daily Connections	4 Ø
Found on	9/26/2026

All bus stations and stops in Chicago and San Antonio, TX

In the map below, you can see where to find all bus stations in Chicago and San Antonio, TX.

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

W Cermak Rd

W Cermak Rd 1001

Bus Station

N St Mary's St 500

San Antonio

Pearl District

Avenue A 699-599

Commerce & Bowie Bus Stop

W. Southcross & Buffalo Bus Stop

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Chicago to San Antonio, TX? Compare all modes of transports from Chicago to San Antonio, TX.

Service and Comfort on the bus from Chicago to San Antonio, TX

Want to know which seat classes are available on the buses from Chicago to San Antonio, TX? Or which bus companies serve the route Chicago to San Antonio, TX? Below you will find answers to your questions.

FAQs about the Chicago to San Antonio, TX bus

How much does a Chicago San Antonio, TX bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $89 and takes 37h 0m to reach San Antonio, TX. Compare offers to save money!

How much could I save by comparing buses from Chicago to San Antonio, TX?

This route is offered by 2 companies with a range of ticket prices between $89 and $142. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to San Antonio, TX.

On average, how many connections are available from Chicago to San Antonio, TX each day?

Every day, the Chicago to San Antonio, TX bus route is served by approximately 9 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Chicago to San Antonio, TX take?

The fastest bus from Chicago to San Antonio, TX is offered by Greyhound US and takes 25h 35m. Bus tickets for this connection cost $133. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Chicago to San Antonio, TX?

The earliest bus arriving in San Antonio, TX from Chicago starts at 6:10 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Chicago to San Antonio, TX?

The latest bus trip departing from Chicago for San Antonio, TX starts at 10:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Chicago San Antonio, TX route?

When traveling by bus from Chicago to San Antonio, TX, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Chicago and San Antonio, TX?

You can check all the direct connections between Chicago and San Antonio, TX by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Chicago to San Antonio, TX bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Chicago San Antonio, TX bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Chicago San Antonio, TX bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Chicago to San Antonio, TX on your planned travel date.

How does CheckMyBus find the best bus deals from Chicago to San Antonio, TX?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 9 daily trips between Chicago and San Antonio, TX. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Chicago to San Antonio, TX?

Prices and availability for 9 trips between Chicago and San Antonio, TX change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Chicago to San Antonio, TX

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Chicago and to San Antonio, TX

Here’s an overview of the most popular bus routes to Chicago and to San Antonio, TX. Simply click on the connection of your choice, and you will find all the details about your bus route!