Bus from Knoxville, TN to Indianapolis from $66

Compare all the bus companies and find the best price with CheckMyBus
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from Knoxville, TN to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from Knoxville, TN to Indianapolis from various bus operators like Greyhound US for the next days.

today
$77
tomorrow
Monday
$83
Tuesday
$82
Wednesday
Thursday
$79
Friday
$73

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 11h 20m 10:00 PM Knoxville, TN Knoxville Area Transit Bus Stop 9:20 AM Indianapolis Central Bus Station  Economy $77
Greyhound US 11h 0m 5:55 PM Knoxville, TN Knoxville Area Transit Bus Stop 4:55 AM Indianapolis Central Bus Station  Economy $78
Greyhound US 15h 15m 10:00 PM Knoxville, TN Greyhound Bus Station 1:15 PM Indianapolis Washington / Delaware  Economy $80
Greyhound US 14h 5m 5:55 PM Knoxville, TN Greyhound Bus Station 8:00 AM Indianapolis Washington / Delaware  Economy $82

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 11h 20m 10:00 PM Knoxville, TN Knoxville Area Transit Bus Stop 9:20 AM Indianapolis Central Bus Station  Economy $83
Greyhound US 11h 0m 5:55 PM Knoxville, TN Knoxville Area Transit Bus Stop 4:55 AM Indianapolis Central Bus Station  Economy $84
Greyhound US 14h 5m 5:55 PM Knoxville, TN Greyhound Bus Station 8:00 AM Indianapolis Washington / Delaware  Economy $87
  • Did you know that if you travel from Knoxville, TN to Indianapolis via Nashville, you can save more than $13? You can find the corresponding connections below.
    • Greyhound US
      15h 35m
      0
      5:55 PM
      Knoxville, TN
      Greyhound Bus Station
      7:55 PM
      Nashville
      5th Ave South Station
      0
      Greyhound US
      Economy
      $36
      • Waiting Time 6h 35m
    • Greyhound US
      6h 0m
      0
      2:30 AM
      Nashville
      5th Ave South Station
      9:30 AM
      Indianapolis
      Central Bus Station
      0
      Greyhound US
      Economy
      $34
    Travel time is 4h 35m longer, but you will save $13

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 14h 5m 5:55 PM Knoxville, TN Greyhound Bus Station 8:00 AM Indianapolis Washington / Delaware  Economy $82
Greyhound US 15h 15m 10:00 PM Knoxville, TN Greyhound Bus Station 1:15 PM Indianapolis Washington / Delaware  Economy $82
Greyhound US 11h 0m 5:55 PM Knoxville, TN Greyhound Bus Station 4:55 AM Indianapolis Central Bus Station  Economy $82
Greyhound US 11h 20m 10:00 PM Knoxville, TN Greyhound Bus Station 9:20 AM Indianapolis Central Bus Station  Economy $114
  • Did you know that if you travel from Knoxville, TN to Indianapolis via Nashville, you can save more than $12? You can find the corresponding connections below.
    • Greyhound US
      15h 35m
      0
      5:55 PM
      Knoxville, TN
      Greyhound Bus Station
      7:55 PM
      Nashville
      5th Ave South Station
      0
      Greyhound US
      Economy
      $36
      • Waiting Time 6h 35m
    • Greyhound US
      6h 0m
      0
      2:30 AM
      Nashville
      5th Ave South Station
      9:30 AM
      Indianapolis
      Central Bus Station
      0
      Greyhound US
      Economy
      $34
    Travel time is 4h 35m longer, but you will save $12

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 11h 0m 5:55 PM Knoxville, TN Knoxville Area Transit Bus Stop 4:55 AM Indianapolis Central Bus Station  Economy $79
Greyhound US 11h 20m 10:00 PM Knoxville, TN Knoxville Area Transit Bus Stop 9:20 AM Indianapolis Central Bus Station  Economy $79
Greyhound US 15h 15m 10:00 PM Knoxville, TN Greyhound Bus Station 1:15 PM Indianapolis Washington / Delaware  Economy $83
Greyhound US 14h 5m 5:55 PM Knoxville, TN Greyhound Bus Station 8:00 AM Indianapolis Washington / Delaware  Economy $87
  • Did you know that if you travel from Knoxville, TN to Indianapolis via Nashville, you can save more than $9? You can find the corresponding connections below.
    • Greyhound US
      15h 35m
      0
      5:55 PM
      Knoxville, TN
      Greyhound Bus Station
      7:55 PM
      Nashville
      5th Ave South Station
      0
      Greyhound US
      Economy
      $36
      • Waiting Time 6h 35m
    • Greyhound US
      6h 0m
      0
      2:30 AM
      Nashville
      5th Ave South Station
      9:30 AM
      Indianapolis
      Central Bus Station
      0
      Greyhound US
      Economy
      $34
    Travel time is 4h 35m longer, but you will save $9

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 11h 0m 5:55 PM Knoxville, TN Knoxville Area Transit Bus Stop 4:55 AM Indianapolis Central Bus Station  Economy $73
Greyhound US 11h 20m 10:00 PM Knoxville, TN Knoxville Area Transit Bus Stop 9:20 AM Indianapolis Central Bus Station  Economy $73

Best Price Offer: The price for the cheapest bus from Knoxville, TN to Indianapolis is $66 on 11/11/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Knoxville, TN and Indianapolis

See here how frequent the connections between Knoxville, TN and Indianapolis are, during different times and days of the week.
Thursday is the busiest day, with more than 6 daily buses from Knoxville, TN to Indianapolis. Friday has instead the fewest connections, with only 2 daily coaches between Knoxville, TN and Indianapolis.
The busiest time of the day is the Afternoon, with 12 buses from Knoxville, TN to Indianapolis, while Evening sees the fewest connections between Knoxville, TN and Indianapolis, with 11 offers.

Facts about the bus from Knoxville, TN to Indianapolis

Compare all providers like Greyhound US that travel 4 times every day by bus from Knoxville, TN to Indianapolis in one click! Book your bus ticket from Knoxville, TN to Indianapolis starting from $66!

Cheapest Bus $66
Fastest Bus 11h 0m
Earliest Bus 5:55 PM
Latest Bus 10:00 PM
Daily Bus Routes 4 Ø
Distance 289.8 miles
Bus Companies Greyhound US

Cheapest bus connections from Knoxville, TN to Indianapolis

Every day, 4 buses from 1 bus companies leave Knoxville, TN for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 10/24/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 10/18
Monday 10/19
Tuesday 10/20
Wednesday 10/21
Thursday 10/22
Friday 10/23
Saturday 10/24
$80
Sunday 10/25
Monday 10/26
$83
Tuesday 10/27
$82
Wednesday 10/28
Thursday 10/29
$83
Friday 10/30
$72
Saturday 10/31
$76
Sunday 11/01
Monday 11/02
$85
Tuesday 11/03
$84
Wednesday 11/04
$83
Thursday 11/05
$71
Friday 11/06
$75
Saturday 11/07
$67
Sunday 11/08
$71
Monday 11/09
$75
Tuesday 11/10
$69
Wednesday 11/11
$66
Thursday 11/12
$68
Friday 11/13
Saturday 11/14

The cheapest time to travel from Knoxville, TN to Indianapolis

See here on which day and which time of the day you can find the cheapest bus ticket from Knoxville, TN to Indianapolis, for the next 30 days.
With a price starting from $67, Saturday is the cheapest day for a bus from Knoxville, TN to Indianapolis. Monday instead is the most expensive day with prices starting from $75.
Afternoon is the cheapest day time for bus tickets from Knoxville, TN to Indianapolis, with $73. Afternoon is the most expensive time of the day with prices starting from $73.

How to save money travelling from Knoxville, TN to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Knoxville, TN to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Knoxville, TN to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Knoxville, TN to Indianapolis are also emptier.

Beloved bus companies from Knoxville, TN to Indianapolis

These are the most booked bus companies between Knoxville, TN to Indianapolis from our users.

Greyhound US from Knoxville, TN to Indianapolis

Greyhound US

Here you will find the key facts about the Greyhound US bus route Knoxville, TN to Indianapolis:

Cheapest Price $73
Fastest Bus 11h 0m
Earliest Bus 5:55 PM
Last Bus 10:00 PM
Daily Connections 4 Ø
Found on 9/30/2026

All bus stations and stops in Knoxville, TN and Indianapolis

In the map below, you can see where to find all bus stations in Knoxville, TN and Indianapolis.

Service and Comfort on the bus from Knoxville, TN to Indianapolis

Want to know which seat classes are available on the buses from Knoxville, TN to Indianapolis? Or which bus companies serve the route Knoxville, TN to Indianapolis? Below you will find answers to your questions.

FAQs about the Knoxville, TN to Indianapolis bus

How much does a Knoxville, TN Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $66 and takes 11h 0m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from Knoxville, TN to Indianapolis?

This route is offered by 1 companies with a range of ticket prices between $66 and $114. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from Knoxville, TN to Indianapolis each day?

Every day, the Knoxville, TN to Indianapolis bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Knoxville, TN to Indianapolis take?

The fastest bus from Knoxville, TN to Indianapolis is offered by Greyhound US and takes 11h 0m. Bus tickets for this connection cost $78. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Knoxville, TN to Indianapolis?

The earliest bus arriving in Indianapolis from Knoxville, TN starts at 5:55 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Knoxville, TN to Indianapolis?

The latest bus trip departing from Knoxville, TN for Indianapolis starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Knoxville, TN Indianapolis route?

When traveling by bus from Knoxville, TN to Indianapolis, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Knoxville, TN and Indianapolis?

You can check all the direct connections between Knoxville, TN and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Knoxville, TN to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Knoxville, TN Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Knoxville, TN Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Knoxville, TN to Indianapolis on your planned travel date.

How does CheckMyBus find the best bus deals from Knoxville, TN to Indianapolis?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Knoxville, TN and Indianapolis. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Knoxville, TN to Indianapolis?

Prices and availability for 4 trips between Knoxville, TN and Indianapolis change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Knoxville, TN to Indianapolis

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Knoxville, TN and to Indianapolis

Here’s an overview of the most popular bus routes to Knoxville, TN and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus Gonzales, LA - Knoxville, TN Bus Gonzales, LA - Knoxville, TN
Bus Big Spring, TX - Knoxville, TN Bus Big Spring, TX - Knoxville, TN
Bus Lafayette, IN - Knoxville, TN Bus Lafayette, IN - Knoxville, TN
Buses from Deming, NM to Knoxville, TN Buses from Deming, NM to Knoxville, TN
Buses from Lawton, OK to Indianapolis Buses from Lawton, OK to Indianapolis
Buses to Indianapolis from Ann Arbor, MI Buses to Indianapolis from Ann Arbor, MI
Bus from Topeka, KS to Indianapolis Bus from Topeka, KS to Indianapolis
Bus Terre Haute, IN to Indianapolis Bus Terre Haute, IN to Indianapolis
Popular Airport Shuttles to Knoxville, TN and to Indianapolis
CheckMyBus › Buses in USA › Bus to Knoxville, TN › Bus to Indianapolis

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

offers,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

to

personalize

the

ads.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.