Bus Chicago to Columbia, MO - Compare all Companies

Compare all timetables for the bus from Chicago to Columbia, MO

Here is a selection of the cheapest bus trips from the schedule from Chicago to Columbia, MO from various bus operators like Greyhound US or FlixBus for the next days.

today

$64

tomorrow

$60

Sunday

$60

Monday

Tuesday

$55

Wednesday

$53

Thursday

$68

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	10h 50m	12:15 AM	Chicago	Downtown Bus Station	11:05 AM	Columbia, MO	Red Thread	Economy	$64	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 10/23/2026 12:15:00 AM to Red Thread, Columbia, MO (USA) arriving at 10/23/2026 11:05:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 10h 50m
FlixBus	10h 25m	12:15 AM	Chicago	Downtown Bus Station	10:40 AM	Columbia, MO	Bus Stop	Economy	$65	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 10/23/2026 12:15:00 AM to Bus Stop, Columbia, MO (USA) arriving at 10/23/2026 10:40:00 AM. 50 Economy ticket for $65 per person are available. Travel duration is 10h 25m
FlixBus	9h 55m	9:45 AM	Chicago	Downtown Bus Station	7:40 PM	Columbia, MO	Red Thread	Economy	$65	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 10/23/2026 9:45:00 AM to Red Thread, Columbia, MO (USA) arriving at 10/23/2026 7:40:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 9h 55m
Greyhound US	16h 15m	10:50 PM	Chicago	Downtown Bus Station	3:05 PM	Columbia, MO	Bus Stop	Economy	$76	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 10/23/2026 10:50:00 PM to Bus Stop, Columbia, MO (USA) arriving at 10/24/2026 3:05:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 16h 15m
Greyhound US	16h 45m	10:50 PM	Chicago	Downtown Bus Station	3:35 PM	Columbia, MO	Red Thread	Economy	$76	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 10/23/2026 10:50:00 PM to Red Thread, Columbia, MO (USA) arriving at 10/24/2026 3:35:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 16h 45m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	10h 25m	12:40 AM	Chicago	95th Red Line Station	11:05 AM	Columbia, MO	Red Thread	Economy	$60	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 10/24/2026 12:40:00 AM to Red Thread, Columbia, MO (USA) arriving at 10/24/2026 11:05:00 AM. 50 Economy ticket for $60 per person are available. Travel duration is 10h 25m
FlixBus	10h 0m	12:40 AM	Chicago	95th Red Line Station	10:40 AM	Columbia, MO	Bus Stop	Economy	$60	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 10/24/2026 12:40:00 AM to Bus Stop, Columbia, MO (USA) arriving at 10/24/2026 10:40:00 AM. 50 Economy ticket for $60 per person are available. Travel duration is 10h 0m
FlixBus	13h 55m	5:45 AM	Chicago	95th Red Line Station	7:40 PM	Columbia, MO	Red Thread	Economy	$61	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 10/24/2026 5:45:00 AM to Red Thread, Columbia, MO (USA) arriving at 10/24/2026 7:40:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 13h 55m
Greyhound US	19h 25m	1:20 PM	Chicago	95th Red Line Station	8:45 AM	Columbia, MO	Red Thread	Economy	$61	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 10/24/2026 1:20:00 PM to Red Thread, Columbia, MO (USA) arriving at 10/25/2026 8:45:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 19h 25m
Greyhound US	19h 0m	1:20 PM	Chicago	95th Red Line Station	8:20 AM	Columbia, MO	Bus Stop	Economy	$61	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 10/24/2026 1:20:00 PM to Bus Stop, Columbia, MO (USA) arriving at 10/25/2026 8:20:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 19h 0m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	10h 0m	12:40 AM	Chicago	95th Red Line Station	10:40 AM	Columbia, MO	Bus Stop	Economy	$60	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 10/25/2026 12:40:00 AM to Bus Stop, Columbia, MO (USA) arriving at 10/25/2026 10:40:00 AM. 50 Economy ticket for $60 per person are available. Travel duration is 10h 0m
FlixBus	10h 25m	12:40 AM	Chicago	95th Red Line Station	11:05 AM	Columbia, MO	Red Thread	Economy	$61	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 10/25/2026 12:40:00 AM to Red Thread, Columbia, MO (USA) arriving at 10/25/2026 11:05:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 10h 25m
FlixBus	10h 50m	12:15 AM	Chicago	Downtown Bus Station	11:05 AM	Columbia, MO	Red Thread	Economy	$62	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 10/25/2026 12:15:00 AM to Red Thread, Columbia, MO (USA) arriving at 10/25/2026 11:05:00 AM. 50 Economy ticket for $62 per person are available. Travel duration is 10h 50m
Greyhound US	19h 25m	1:20 PM	Chicago	95th Red Line Station	8:45 AM	Columbia, MO	Red Thread	Economy	$69	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 10/25/2026 1:20:00 PM to Red Thread, Columbia, MO (USA) arriving at 10/26/2026 8:45:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 19h 25m
Greyhound US	19h 0m	1:20 PM	Chicago	95th Red Line Station	8:20 AM	Columbia, MO	Bus Stop	Economy	$69	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 10/25/2026 1:20:00 PM to Bus Stop, Columbia, MO (USA) arriving at 10/26/2026 8:20:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 19h 0m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	22h 30m	10:15 AM	Chicago	Canal & Van Buren	8:45 AM	Columbia, MO	Red Thread	Economy	$55	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 10/27/2026 10:15:00 AM to Red Thread, Columbia, MO (USA) arriving at 10/28/2026 8:45:00 AM. 50 Economy ticket for $55 per person are available. Travel duration is 22h 30m
Greyhound US	22h 5m	10:15 AM	Chicago	Canal & Van Buren	8:20 AM	Columbia, MO	Bus Stop	Economy	$55	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 10/27/2026 10:15:00 AM to Bus Stop, Columbia, MO (USA) arriving at 10/28/2026 8:20:00 AM. 50 Economy ticket for $55 per person are available. Travel duration is 22h 5m
Greyhound US	18h 0m	2:45 PM	Chicago	Downtown Bus Station	8:45 AM	Columbia, MO	Red Thread	Economy	$55	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 10/27/2026 2:45:00 PM to Red Thread, Columbia, MO (USA) arriving at 10/28/2026 8:45:00 AM. 50 Economy ticket for $55 per person are available. Travel duration is 18h 0m
Greyhound US	17h 35m	2:45 PM	Chicago	Downtown Bus Station	8:20 AM	Columbia, MO	Bus Stop	Economy	$56	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 10/27/2026 2:45:00 PM to Bus Stop, Columbia, MO (USA) arriving at 10/28/2026 8:20:00 AM. 50 Economy ticket for $56 per person are available. Travel duration is 17h 35m
Greyhound US	15h 55m	11:10 PM	Chicago	Canal & Van Buren	3:05 PM	Columbia, MO	Bus Stop	Economy	$58	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 10/27/2026 11:10:00 PM to Bus Stop, Columbia, MO (USA) arriving at 10/28/2026 3:05:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 15h 55m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	19h 25m	1:20 PM	Chicago	95th Red Line Station	8:45 AM	Columbia, MO	Red Thread	Economy	$53	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 10/28/2026 1:20:00 PM to Red Thread, Columbia, MO (USA) arriving at 10/29/2026 8:45:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 19h 25m
Greyhound US	19h 0m	1:20 PM	Chicago	95th Red Line Station	8:20 AM	Columbia, MO	Bus Stop	Economy	$54	A Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 10/28/2026 1:20:00 PM to Bus Stop, Columbia, MO (USA) arriving at 10/29/2026 8:20:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 19h 0m
Greyhound US	17h 35m	2:45 PM	Chicago	Downtown Bus Station	8:20 AM	Columbia, MO	Bus Stop	Economy	$56	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 10/28/2026 2:45:00 PM to Bus Stop, Columbia, MO (USA) arriving at 10/29/2026 8:20:00 AM. 50 Economy ticket for $56 per person are available. Travel duration is 17h 35m
Greyhound US	18h 0m	2:45 PM	Chicago	Downtown Bus Station	8:45 AM	Columbia, MO	Red Thread	Economy	$57	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 10/28/2026 2:45:00 PM to Red Thread, Columbia, MO (USA) arriving at 10/29/2026 8:45:00 AM. 50 Economy ticket for $57 per person are available. Travel duration is 18h 0m
Greyhound US	22h 5m	10:15 AM	Chicago	Canal & Van Buren	8:20 AM	Columbia, MO	Bus Stop	Economy	$58	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 10/28/2026 10:15:00 AM to Bus Stop, Columbia, MO (USA) arriving at 10/29/2026 8:20:00 AM. 50 Economy ticket for $58 per person are available. Travel duration is 22h 5m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	15h 15m	5:05 PM	Chicago	Downtown Bus Station	8:20 AM	Columbia, MO	Bus Stop	Economy	$68	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 10/29/2026 5:05:00 PM to Bus Stop, Columbia, MO (USA) arriving at 10/30/2026 8:20:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 15h 15m
FlixBus	10h 50m	12:15 AM	Chicago	Downtown Bus Station	11:05 AM	Columbia, MO	Red Thread	Economy	$68	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 10/29/2026 12:15:00 AM to Red Thread, Columbia, MO (USA) arriving at 10/29/2026 11:05:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 10h 50m
FlixBus	15h 40m	5:05 PM	Chicago	Downtown Bus Station	8:45 AM	Columbia, MO	Red Thread	Economy	$68	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 10/29/2026 5:05:00 PM to Red Thread, Columbia, MO (USA) arriving at 10/30/2026 8:45:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 15h 40m
Greyhound US	16h 25m	11:10 PM	Chicago	Union Station	3:35 PM	Columbia, MO	Red Thread	Economy	$76	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 10/29/2026 11:10:00 PM to Red Thread, Columbia, MO (USA) arriving at 10/30/2026 3:35:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 16h 25m
Greyhound US	16h 45m	10:50 PM	Chicago	Downtown Bus Station	3:35 PM	Columbia, MO	Red Thread	Economy	$77	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 10/29/2026 10:50:00 PM to Red Thread, Columbia, MO (USA) arriving at 10/30/2026 3:35:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 16h 45m

Did you know that if you travel from Chicago to Columbia, MO via St. Louis, MO, you can save more than $10? You can find the corresponding connections below.
- FlixBus
  
  10h 0m
  
  0
  
  12:40 AM
  
  Chicago
  95th Red Line Station
  
  6:20 AM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $39
  
  A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 10/29/2026 12:40:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 10/29/2026 6:20:00 AM. 50 Economy ticket for $39 per person are available. Travel duration is 5h 40m
- Greyhound US
  
  3h 0m
  
  0
  
  7:40 AM
  
  St. Louis, MO
  Gateway Station
  
  10:40 AM
  
  Columbia, MO
  Bus Stop
  
  0
  
  Economy
  
  $19
  
  A Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 10/29/2026 7:40:00 AM to Bus Stop, Columbia, MO (USA) arriving at 10/29/2026 10:40:00 AM. 50 Economy ticket for $19 per person are available. Travel duration is 3h 0m
Travel Time is 0h 50m shorter, and you will save $10

Best Price Offer: The price for the cheapest bus from Chicago to Columbia, MO is $53 on 10/28/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Chicago and Columbia, MO

See here how frequent the connections between Chicago and Columbia, MO are, during different times and days of the week.

Saturday is the busiest day, with more than 32 daily buses from Chicago to Columbia, MO. Thursday has instead the fewest connections, with only 9 daily coaches between Chicago and Columbia, MO.

The busiest time of the day is the Evening, with 42 buses from Chicago to Columbia, MO, while Morning sees the fewest connections between Chicago and Columbia, MO, with 11 offers.

Facts about the bus from Chicago to Columbia, MO

Compare all providers like Greyhound US and FlixBus that travel 16 times every day by bus from Chicago to Columbia, MO in one click! Book your bus ticket from Chicago to Columbia, MO starting from $53!

Cheapest Bus	$53
Fastest Bus	9h 55m
Earliest Bus	12:15 AM
Latest Bus	11:10 PM
Daily Bus Routes	16 Ø
Distance	318.7 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Chicago to Columbia, MO

Every day, 16 buses from 2 bus companies leave Chicago for Columbia, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 10/23/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 10/18

Monday 10/19

Tuesday 10/20

Wednesday 10/21

Thursday 10/22

Friday 10/23

$64

Saturday 10/24

$60

Sunday 10/25

$60

Monday 10/26

Tuesday 10/27

$55

Wednesday 10/28

$53

Thursday 10/29

$68

Friday 10/30

Saturday 10/31

$64

Sunday 11/01

Monday 11/02

$66

Tuesday 11/03

$59

Wednesday 11/04

Thursday 11/05

$58

Friday 11/06

$67

Saturday 11/07

$59

Sunday 11/08

$60

Monday 11/09

$55

Tuesday 11/10

$63

Wednesday 11/11

$62

Thursday 11/12

$57

Friday 11/13

Saturday 11/14

The cheapest time to travel from Chicago to Columbia, MO

See here on which day and which time of the day you can find the cheapest bus ticket from Chicago to Columbia, MO, for the next 30 days.

With a price starting from $53, Wednesday is the cheapest day for a bus from Chicago to Columbia, MO. Friday instead is the most expensive day with prices starting from $64.

Afternoon is the cheapest day time for bus tickets from Chicago to Columbia, MO, with $53. Evening is the most expensive time of the day with prices starting from $58.

How to save money travelling from Chicago to Columbia, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Chicago to Columbia, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Chicago to Columbia, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Chicago to Columbia, MO are also emptier.

Beloved bus companies from Chicago to Columbia, MO

These are the most booked bus companies between Chicago to Columbia, MO from our users.

FlixBus from Chicago to Columbia, MO

Here you will find the key facts about the FlixBus bus route Chicago to Columbia, MO:

Cheapest Price	$60
Fastest Bus	9h 55m
Earliest Bus	12:15 AM
Last Bus	5:05 PM
Daily Connections	8 Ø
Found on	10/20/2026

Greyhound US from Chicago to Columbia, MO

Here you will find the key facts about the Greyhound US bus route Chicago to Columbia, MO:

Cheapest Price	$53
Fastest Bus	15h 25m
Earliest Bus	10:50 PM
Last Bus	11:10 PM
Daily Connections	10 Ø
Found on	10/20/2026

All bus stations and stops in Chicago and Columbia, MO

In the map below, you can see where to find all bus stations in Chicago and Columbia, MO.

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Bus Stop

N 10th St 198

Red Thread

Highway 40 W 6401

University

Fellows Pl 1301-1349

Service and Comfort on the bus from Chicago to Columbia, MO

Want to know which seat classes are available on the buses from Chicago to Columbia, MO? Or which bus companies serve the route Chicago to Columbia, MO? Below you will find answers to your questions.

FAQs about the Chicago to Columbia, MO bus

How much does a Chicago Columbia, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $53 and takes 19h 25m to reach Columbia, MO. Compare offers to save money!

How much could I save by comparing buses from Chicago to Columbia, MO?

This route is offered by 2 companies with a range of ticket prices between $53 and $98. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Columbia, MO.

On average, how many connections are available from Chicago to Columbia, MO each day?

Every day, the Chicago to Columbia, MO bus route is served by approximately 16 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Chicago to Columbia, MO take?

The fastest bus from Chicago to Columbia, MO is offered by FlixBus and takes 9h 55m. Bus tickets for this connection cost $65. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Chicago to Columbia, MO?

The earliest bus arriving in Columbia, MO from Chicago starts at 12:15 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Chicago to Columbia, MO?

The latest bus trip departing from Chicago for Columbia, MO starts at 11:10 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Chicago Columbia, MO route?

When traveling by bus from Chicago to Columbia, MO, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Chicago and Columbia, MO?

You can check all the direct connections between Chicago and Columbia, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Chicago to Columbia, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Chicago Columbia, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Chicago Columbia, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Chicago to Columbia, MO on your planned travel date.

How does CheckMyBus find the best bus deals from Chicago to Columbia, MO?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 16 daily trips between Chicago and Columbia, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Chicago to Columbia, MO?

Prices and availability for 16 trips between Chicago and Columbia, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Chicago to Columbia, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Chicago and to Columbia, MO

Here’s an overview of the most popular bus routes to Chicago and to Columbia, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!