Bus from Wilmington, DE to Greenville, SC from $66

Compare all the bus companies and find the best price with CheckMyBus
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from Wilmington, DE to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Wilmington, DE to Greenville, SC from various bus operators like Greyhound US for the next days.

today
tomorrow
Saturday
$83
Sunday
Monday
Tuesday
Wednesday
$72

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 13h 40m 12:55 AM Wilmington, DE Greyhound 2:35 PM Greenville, SC Woodruff Rd  Economy $83
Greyhound US 18h 50m 1:50 PM Wilmington, DE Greyhound 8:40 AM Greenville, SC Woodruff Rd  Economy $83
Greyhound US 17h 5m 8:10 PM Wilmington, DE Greyhound 1:15 PM Greenville, SC Woodruff Rd  Economy $83
Greyhound US 15h 55m 3:40 AM Wilmington, DE Greyhound 7:35 PM Greenville, SC Woodruff Rd  Economy $84
Greyhound US 21h 50m 9:45 PM Wilmington, DE Greyhound 7:35 PM Greenville, SC Woodruff Rd  Economy $84

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 18h 25m 1:45 AM Wilmington, DE Greyhound 8:10 PM Greenville, SC Woodruff Rd  Economy $72
Greyhound US 18h 50m 1:50 PM Wilmington, DE Greyhound 8:40 AM Greenville, SC Woodruff Rd  Economy $72
Greyhound US 22h 25m 9:45 PM Wilmington, DE Greyhound 8:10 PM Greenville, SC Woodruff Rd  Economy $73
Greyhound US 17h 5m 8:10 PM Wilmington, DE Greyhound 1:15 PM Greenville, SC Woodruff Rd  Economy $79
Greyhound US 13h 40m 12:55 AM Wilmington, DE Greyhound 2:35 PM Greenville, SC Woodruff Rd  Economy $90

Best Price Offer: The price for the cheapest bus from Wilmington, DE to Greenville, SC is $66 on 9/9/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Wilmington, DE and Greenville, SC

See here how frequent the connections between Wilmington, DE and Greenville, SC are, during different times and days of the week.
Wednesday is the busiest day, with more than 5 daily buses from Wilmington, DE to Greenville, SC. Wednesday has instead the fewest connections, with only 5 daily coaches between Wilmington, DE and Greenville, SC.
The busiest time of the day is the Evening, with 4 buses from Wilmington, DE to Greenville, SC, while Afternoon sees the fewest connections between Wilmington, DE and Greenville, SC, with 2 offers.

Facts about the bus from Wilmington, DE to Greenville, SC

Compare all providers like Greyhound US that travel 5 times every day by bus from Wilmington, DE to Greenville, SC in one click! Book your bus ticket from Wilmington, DE to Greenville, SC starting from $66!

Cheapest Bus $66
Fastest Bus 13h 40m
Earliest Bus 12:55 AM
Latest Bus 9:45 PM
Daily Bus Routes 5 Ø
Distance 505.8 miles
Bus Companies Greyhound US

Cheapest bus connections from Wilmington, DE to Greenville, SC

Every day, 5 buses from 1 bus companies leave Wilmington, DE for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 08/27/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 08/23
Monday 08/24
Tuesday 08/25
Wednesday 08/26
Thursday 08/27
Friday 08/28
Saturday 08/29
$82
Sunday 08/30
Monday 08/31
Tuesday 09/01
$146
Wednesday 09/02
$72
Thursday 09/03
$70
Friday 09/04
$81
Saturday 09/05
Sunday 09/06
Monday 09/07
$89
Tuesday 09/08
Wednesday 09/09
$66
Thursday 09/10
Friday 09/11
Saturday 09/12
Sunday 09/13
$71
Monday 09/14
$68
Tuesday 09/15
$68
Wednesday 09/16
Thursday 09/17
Friday 09/18
Saturday 09/19

The cheapest time to travel from Wilmington, DE to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Wilmington, DE to Greenville, SC, for the next 30 days.
With a price starting from $66, Wednesday is the cheapest day for a bus from Wilmington, DE to Greenville, SC. Saturday instead is the most expensive day with prices starting from $70.
Night is the cheapest day time for bus tickets from Wilmington, DE to Greenville, SC, with $66. Evening is the most expensive time of the day with prices starting from $73.

How to save money travelling from Wilmington, DE to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Wilmington, DE to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Wilmington, DE to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Wilmington, DE to Greenville, SC are also emptier.

All bus stations and stops in Wilmington, DE and Greenville, SC

In the map below, you can see where to find all bus stations in Wilmington, DE and Greenville, SC.

Service and Comfort on the bus from Wilmington, DE to Greenville, SC

Want to know which seat classes are available on the buses from Wilmington, DE to Greenville, SC? Or which bus companies serve the route Wilmington, DE to Greenville, SC? Below you will find answers to your questions.

FAQs about the Wilmington, DE to Greenville, SC bus

How much does a Wilmington, DE Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $66 and takes 18h 25m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Wilmington, DE to Greenville, SC?

This route is offered by 1 companies with a range of ticket prices between $66 and $90. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Wilmington, DE to Greenville, SC each day?

Every day, the Wilmington, DE to Greenville, SC bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Wilmington, DE to Greenville, SC take?

The fastest bus from Wilmington, DE to Greenville, SC is offered by Greyhound US and takes 13h 40m. Bus tickets for this connection cost $83. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Wilmington, DE to Greenville, SC?

The earliest bus arriving in Greenville, SC from Wilmington, DE starts at 12:55 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Wilmington, DE to Greenville, SC?

The latest bus trip departing from Wilmington, DE for Greenville, SC starts at 9:45 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Wilmington, DE Greenville, SC route?

When traveling by bus from Wilmington, DE to Greenville, SC, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Wilmington, DE and Greenville, SC?

You can check all the direct connections between Wilmington, DE and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Wilmington, DE to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Wilmington, DE Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Wilmington, DE Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Wilmington, DE to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Wilmington, DE to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 5 daily trips between Wilmington, DE and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Wilmington, DE to Greenville, SC?

Prices and availability for 5 trips between Wilmington, DE and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Wilmington, DE to Greenville, SC

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Wilmington, DE and to Greenville, SC

Here’s an overview of the most popular bus routes to Wilmington, DE and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus Greenville, NC to Wilmington, DE Bus Greenville, NC to Wilmington, DE
Buses to Wilmington, DE from Macon, GA Buses to Wilmington, DE from Macon, GA
Bus New Smyrna Beach, FL - Wilmington, DE Bus New Smyrna Beach, FL - Wilmington, DE
Bus Arlington, VA - Wilmington, DE Bus Arlington, VA - Wilmington, DE
From College Park, MD to Greenville, SC bus From College Park, MD to Greenville, SC bus
From Toledo, OH to Greenville, SC bus From Toledo, OH to Greenville, SC bus
Buses Salisbury, NC to Greenville, SC Buses Salisbury, NC to Greenville, SC
Bus Guadalajara, JC to Greenville, SC Bus Guadalajara, JC to Greenville, SC
Popular Airport Shuttles to Wilmington, DE and to Greenville, SC
CheckMyBus › Buses in USA › Bus to Wilmington, DE › Bus to Greenville, SC

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

offers,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

to

personalize

the

ads.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.