Bus from Tupelo, MS to Indianapolis from $68

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Compare all timetables for the bus from Tupelo, MS to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from Tupelo, MS to Indianapolis from various bus operators like Greyhound US for the next days.

today
$73
tomorrow
$68
Thursday
$83
Friday
Saturday
Sunday
$97
Monday
$96

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 21h 35m 10:55 AM Tupelo, MS Bus Stop 9:30 AM Indianapolis Central Bus Station  Economy $73
Greyhound US 21h 30m 11:15 PM Tupelo, MS Bus Stop 9:45 PM Indianapolis Washington / Delaware  Economy $73
Greyhound US 13h 25m 9:45 PM Tupelo, MS Bus Stop 12:10 PM Indianapolis Central Bus Station  Economy $75
Greyhound US 21h 40m 5:35 AM Tupelo, MS Bus Stop 4:15 AM Indianapolis Central Bus Station  Economy $82

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 21h 35m 10:55 AM Tupelo, MS Bus Stop 9:30 AM Indianapolis Central Bus Station  Economy $68
Greyhound US 13h 25m 9:45 PM Tupelo, MS Bus Stop 12:10 PM Indianapolis Central Bus Station  Economy $69
Greyhound US 21h 40m 5:35 AM Tupelo, MS Bus Stop 4:15 AM Indianapolis Central Bus Station  Economy $72
Greyhound US 21h 30m 11:15 PM Tupelo, MS Bus Stop 9:45 PM Indianapolis Washington / Delaware  Economy $77
Greyhound US 20h 5m 10:55 AM Tupelo, MS Bus Stop 8:00 AM Indianapolis Washington / Delaware  Economy $78

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 21h 35m 10:55 AM Tupelo, MS Bus Stop 9:30 AM Indianapolis Central Bus Station  Economy $83
Greyhound US 20h 5m 10:55 AM Tupelo, MS Bus Stop 8:00 AM Indianapolis Washington / Delaware  Economy $87
Greyhound US 13h 25m 9:45 PM Tupelo, MS Bus Stop 12:10 PM Indianapolis Central Bus Station  Economy $92
Greyhound US 21h 40m 5:35 AM Tupelo, MS Bus Stop 4:15 AM Indianapolis Central Bus Station  Economy $93

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 13h 25m 9:45 PM Tupelo, MS Bus Stop 12:10 PM Indianapolis Central Bus Station  Economy $97
Greyhound US 20h 5m 10:55 AM Tupelo, MS Bus Stop 8:00 AM Indianapolis Washington / Delaware  Economy $97
Greyhound US 21h 35m 10:55 AM Tupelo, MS Bus Stop 9:30 AM Indianapolis Central Bus Station  Economy $99
Greyhound US 21h 30m 11:15 PM Tupelo, MS Bus Stop 9:45 PM Indianapolis Washington / Delaware  Economy $99
Greyhound US 21h 40m 5:35 AM Tupelo, MS Bus Stop 4:15 AM Indianapolis Central Bus Station  Economy $107
  • Did you know that if you travel from Tupelo, MS to Indianapolis via Nashville, you can save more than $19? You can find the corresponding connections below.
    • Greyhound US
      13h 25m
      0
      9:45 PM
      Tupelo, MS
      Bus Stop
      4:25 AM
      Nashville
      5th Ave South Station
      0
      Greyhound US
      Economy
      $44
      • Waiting Time 0h 50m
    • Greyhound US
      5h 55m
      0
      5:15 AM
      Nashville
      5th Ave South Station
      12:10 PM
      Indianapolis
      Central Bus Station
      0
      Greyhound US
      Economy
      $34
    Travel Time is 1h 0m shorter, and you will save $19

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 13h 25m 9:45 PM Tupelo, MS Bus Stop 12:10 PM Indianapolis Central Bus Station  Economy $96
Greyhound US 20h 5m 10:55 AM Tupelo, MS Bus Stop 8:00 AM Indianapolis Washington / Delaware  Economy $96
Greyhound US 21h 35m 10:55 AM Tupelo, MS Bus Stop 9:30 AM Indianapolis Central Bus Station  Economy $97
Greyhound US 21h 30m 11:15 PM Tupelo, MS Bus Stop 9:45 PM Indianapolis Washington / Delaware  Economy $97
Greyhound US 21h 40m 5:35 AM Tupelo, MS Bus Stop 4:15 AM Indianapolis Central Bus Station  Economy $113
  • Did you know that if you travel from Tupelo, MS to Indianapolis via Nashville, you can save more than $18? You can find the corresponding connections below.
    • Greyhound US
      13h 25m
      0
      9:45 PM
      Tupelo, MS
      Bus Stop
      4:25 AM
      Nashville
      5th Ave South Station
      0
      Greyhound US
      Economy
      $44
      • Waiting Time 0h 50m
    • Greyhound US
      5h 55m
      0
      5:15 AM
      Nashville
      5th Ave South Station
      12:10 PM
      Indianapolis
      Central Bus Station
      0
      Greyhound US
      Economy
      $34
    Travel Time is 1h 0m shorter, and you will save $18

Best Price Offer: The price for the cheapest bus from Tupelo, MS to Indianapolis is $68 on 8/26/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Tupelo, MS and Indianapolis

See here how frequent the connections between Tupelo, MS and Indianapolis are, during different times and days of the week.
Wednesday is the busiest day, with more than 8 daily buses from Tupelo, MS to Indianapolis. Tuesday has instead the fewest connections, with only 4 daily coaches between Tupelo, MS and Indianapolis.
The busiest time of the day is the Morning, with 11 buses from Tupelo, MS to Indianapolis, while Night sees the fewest connections between Tupelo, MS and Indianapolis, with 7 offers.

Facts about the bus from Tupelo, MS to Indianapolis

Compare all providers like Greyhound US that travel 5 times every day by bus from Tupelo, MS to Indianapolis in one click! Book your bus ticket from Tupelo, MS to Indianapolis starting from $68!

Cheapest Bus $68
Fastest Bus 14h 25m
Earliest Bus 5:35 AM
Latest Bus 11:15 PM
Daily Bus Routes 5 Ø
Distance 405.9 miles
Bus Companies Greyhound US

Cheapest bus connections from Tupelo, MS to Indianapolis

Every day, 5 buses from 1 bus companies leave Tupelo, MS for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 08/25/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 08/23
Monday 08/24
Tuesday 08/25
$73
Wednesday 08/26
$77
Thursday 08/27
$87
Friday 08/28
Saturday 08/29
Sunday 08/30
$97
Monday 08/31
$96
Tuesday 09/01
Wednesday 09/02
Thursday 09/03
$86
Friday 09/04
$95
Saturday 09/05
Sunday 09/06
$89
Monday 09/07
$96
Tuesday 09/08
$78
Wednesday 09/09
$79
Thursday 09/10
$82
Friday 09/11
Saturday 09/12
$76
Sunday 09/13
Monday 09/14
Tuesday 09/15
$73
Wednesday 09/16
$71
Thursday 09/17
Friday 09/18
Saturday 09/19

The cheapest time to travel from Tupelo, MS to Indianapolis

See here on which day and which time of the day you can find the cheapest bus ticket from Tupelo, MS to Indianapolis, for the next 30 days.
With a price starting from $68, Wednesday is the cheapest day for a bus from Tupelo, MS to Indianapolis. Monday instead is the most expensive day with prices starting from $96.
Morning is the cheapest day time for bus tickets from Tupelo, MS to Indianapolis, with $68. Night is the most expensive time of the day with prices starting from $71.

How to save money travelling from Tupelo, MS to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Tupelo, MS to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Tupelo, MS to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Tupelo, MS to Indianapolis are also emptier.

Beloved bus companies from Tupelo, MS to Indianapolis

These are the most booked bus companies between Tupelo, MS to Indianapolis from our users.

Greyhound US from Tupelo, MS to Indianapolis

Greyhound US

Here you will find the key facts about the Greyhound US bus route Tupelo, MS to Indianapolis:

Cheapest Price $68
Fastest Bus 14h 25m
Earliest Bus 5:35 AM
Last Bus 11:15 PM
Daily Connections 5 Ø
Found on 8/1/2026

All bus stations and stops in Tupelo, MS and Indianapolis

In the map below, you can see where to find all bus stations in Tupelo, MS and Indianapolis.

Service and Comfort on the bus from Tupelo, MS to Indianapolis

Want to know which seat classes are available on the buses from Tupelo, MS to Indianapolis? Or which bus companies serve the route Tupelo, MS to Indianapolis? Below you will find answers to your questions.

FAQs about the Tupelo, MS to Indianapolis bus

How much does a Tupelo, MS Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $68 and takes 22h 35m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from Tupelo, MS to Indianapolis?

This route is offered by 1 companies with a range of ticket prices between $68 and $113. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from Tupelo, MS to Indianapolis each day?

Every day, the Tupelo, MS to Indianapolis bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Tupelo, MS to Indianapolis take?

The fastest bus from Tupelo, MS to Indianapolis is offered by Greyhound US and takes 14h 25m. Bus tickets for this connection cost $75. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Tupelo, MS to Indianapolis?

The earliest bus arriving in Indianapolis from Tupelo, MS starts at 5:35 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Tupelo, MS to Indianapolis?

The latest bus trip departing from Tupelo, MS for Indianapolis starts at 11:15 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Tupelo, MS Indianapolis route?

When traveling by bus from Tupelo, MS to Indianapolis, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Tupelo, MS and Indianapolis?

You can check all the direct connections between Tupelo, MS and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Tupelo, MS to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Tupelo, MS Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Tupelo, MS Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Tupelo, MS to Indianapolis on your planned travel date.

How does CheckMyBus find the best bus deals from Tupelo, MS to Indianapolis?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 5 daily trips between Tupelo, MS and Indianapolis. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Tupelo, MS to Indianapolis?

Prices and availability for 5 trips between Tupelo, MS and Indianapolis change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Tupelo, MS to Indianapolis

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Tupelo, MS and to Indianapolis

Here’s an overview of the most popular bus routes to Tupelo, MS and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Bus from Salt Lake City, UT to Tupelo, MS Bus from Salt Lake City, UT to Tupelo, MS
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Popular Airport Shuttles to Tupelo, MS and to Indianapolis
CheckMyBus › Buses in USA › Bus to Tupelo, MS › Bus to Indianapolis

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