Bus from San Francisco to Indianapolis from $122

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Compare all timetables for the bus from San Francisco to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from San Francisco to Indianapolis from various bus operators like Greyhound US or FlixBus for the next days.

today
$123
tomorrow
Saturday
$122
Sunday
Monday
$131
Tuesday
Wednesday

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 61h 5m 7:10 AM San Francisco 5th/Townsend 11:15 PM Indianapolis Washington / Delaware  Economy $123
FlixBus 57h 20m 7:10 AM San Francisco 5th/Townsend 7:30 PM Indianapolis Central Bus Station  Economy $123
Greyhound US 51h 0m 1:30 PM San Francisco Bus Station Transbay 7:30 PM Indianapolis Central Bus Station  Economy $124
Greyhound US 54h 45m 1:30 PM San Francisco Bus Station Transbay 11:15 PM Indianapolis Washington / Delaware  Economy $125
Greyhound US 61h 0m 10:30 PM San Francisco Bus Station Transbay 2:30 PM Indianapolis Central Bus Station  Economy $176

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 51h 0m 1:30 PM San Francisco Bus Station Transbay 7:30 PM Indianapolis Central Bus Station  Economy $122
Greyhound US 54h 45m 1:30 PM San Francisco Bus Station Transbay 11:15 PM Indianapolis Washington / Delaware  Economy $123
Greyhound US 68h 15m 10:30 PM San Francisco Bus Station Transbay 9:45 PM Indianapolis Washington / Delaware  Economy $170
Greyhound US 61h 0m 10:30 PM San Francisco Bus Station Transbay 2:30 PM Indianapolis Central Bus Station  Economy $179

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 54h 45m 1:30 PM San Francisco Bus Station Transbay 11:15 PM Indianapolis Washington / Delaware  Economy $131
Greyhound US 51h 0m 1:30 PM San Francisco Bus Station Transbay 7:30 PM Indianapolis Central Bus Station  Economy $134
FlixBus 61h 5m 7:10 AM San Francisco 5th/Townsend 11:15 PM Indianapolis Washington / Delaware  Economy $188
FlixBus 57h 20m 7:10 AM San Francisco 5th/Townsend 7:30 PM Indianapolis Central Bus Station  Economy $190
Greyhound US 68h 15m 10:30 PM San Francisco Bus Station Transbay 9:45 PM Indianapolis Washington / Delaware  Economy $195

Best Price Offer: The price for the cheapest bus from San Francisco to Indianapolis is $122 on 8/29/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between San Francisco and Indianapolis

See here how frequent the connections between San Francisco and Indianapolis are, during different times and days of the week.
Monday is the busiest day, with more than 6 daily buses from San Francisco to Indianapolis. Saturday has instead the fewest connections, with only 4 daily coaches between San Francisco and Indianapolis.
The busiest time of the day is the Afternoon, with 6 buses from San Francisco to Indianapolis, while Morning sees the fewest connections between San Francisco and Indianapolis, with 4 offers.

Facts about the bus from San Francisco to Indianapolis

Compare all providers like Greyhound US and FlixBus that travel 5 times every day by bus from San Francisco to Indianapolis in one click! Book your bus ticket from San Francisco to Indianapolis starting from $122!

Cheapest Bus $122
Fastest Bus 54h 0m
Earliest Bus 7:10 AM
Latest Bus 10:30 PM
Daily Bus Routes 5 Ø
Distance 1,944.5 miles
Bus Companies Greyhound US and FlixBus

Cheapest bus connections from San Francisco to Indianapolis

Every day, 5 buses from 2 bus companies leave San Francisco for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 08/27/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 08/23
Monday 08/24
Tuesday 08/25
Wednesday 08/26
Thursday 08/27
$123
Friday 08/28
Saturday 08/29
$122
Sunday 08/30
Monday 08/31
$131
Tuesday 09/01
Wednesday 09/02
Thursday 09/03
$139
Friday 09/04
Saturday 09/05
$122
Sunday 09/06
Monday 09/07
Tuesday 09/08
Wednesday 09/09
Thursday 09/10
Friday 09/11
Saturday 09/12
$132
Sunday 09/13
$147
Monday 09/14
Tuesday 09/15
Wednesday 09/16
Thursday 09/17
Friday 09/18
Saturday 09/19

The cheapest time to travel from San Francisco to Indianapolis

See here on which day and which time of the day you can find the cheapest bus ticket from San Francisco to Indianapolis, for the next 30 days.
With a price starting from $122, Saturday is the cheapest day for a bus from San Francisco to Indianapolis. Monday instead is the most expensive day with prices starting from $131.
Afternoon is the cheapest day time for bus tickets from San Francisco to Indianapolis, with $122. Evening is the most expensive time of the day with prices starting from $170.

How to save money travelling from San Francisco to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Francisco to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Francisco to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Francisco to Indianapolis are also emptier.

Beloved bus companies from San Francisco to Indianapolis

These are the most booked bus companies between San Francisco to Indianapolis from our users.

FlixBus from San Francisco to Indianapolis

FlixBus

Here you will find the key facts about the FlixBus bus route San Francisco to Indianapolis:

Cheapest Price $123
Fastest Bus 60h 20m
Earliest Bus 7:10 AM
Last Bus 7:10 AM
Daily Connections 2 Ø
Found on 8/1/2026

All bus stations and stops in San Francisco and Indianapolis

In the map below, you can see where to find all bus stations in San Francisco and Indianapolis.

Service and Comfort on the bus from San Francisco to Indianapolis

Want to know which seat classes are available on the buses from San Francisco to Indianapolis? Or which bus companies serve the route San Francisco to Indianapolis? Below you will find answers to your questions.

FAQs about the San Francisco to Indianapolis bus

How much does a San Francisco Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $122 and takes 54h 0m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from San Francisco to Indianapolis?

This route is offered by 2 companies with a range of ticket prices between $122 and $208. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from San Francisco to Indianapolis each day?

Every day, the San Francisco to Indianapolis bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Francisco to Indianapolis take?

The fastest bus from San Francisco to Indianapolis is offered by Greyhound US and takes 54h 0m. Bus tickets for this connection cost $124. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Francisco to Indianapolis?

The earliest bus arriving in Indianapolis from San Francisco starts at 7:10 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Francisco to Indianapolis?

The latest bus trip departing from San Francisco for Indianapolis starts at 10:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Francisco Indianapolis route?

When traveling by bus from San Francisco to Indianapolis, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Francisco and Indianapolis?

You can check all the direct connections between San Francisco and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the San Francisco to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Francisco Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Francisco Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Francisco to Indianapolis on your planned travel date.

How does CheckMyBus find the best bus deals from San Francisco to Indianapolis?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 5 daily trips between San Francisco and Indianapolis. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Francisco to Indianapolis?

Prices and availability for 5 trips between San Francisco and Indianapolis change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Francisco to Indianapolis

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Francisco and to Indianapolis

Here’s an overview of the most popular bus routes to San Francisco and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!
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From Tampa to Indianapolis bus From Tampa to Indianapolis bus
Popular Airport Shuttles to San Francisco and to Indianapolis
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