Bus San Antonio, TX to Louisville, KY: Compare prices and save money

Compare all timetables for the bus from San Antonio, TX to Louisville, KY

Here is a selection of the cheapest bus trips from the schedule from San Antonio, TX to Louisville, KY from various bus operators like FlixBus, Greyhound US or Greyhound Lines Mexico for the next days.

today

$104

tomorrow

$113

Sunday

$115

Monday

Tuesday

$106

Wednesday

$117

Thursday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	23h 15m	4:20 AM	San Antonio, TX	Bus Station	4:35 AM	Louisville, KY	Greyhound Bus Station	Economy	$104	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 10/23/2026 4:20:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/24/2026 4:35:00 AM. 50 Economy ticket for $104 per person are available. Travel duration is 23h 15m
Greyhound US	25h 21m	11:59 AM	San Antonio, TX	Bus Station	2:20 PM	Louisville, KY	Greyhound Bus Station	Economy	$106	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 10/23/2026 11:59:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/24/2026 2:20:00 PM. 50 Economy ticket for $106 per person are available. Travel duration is 25h 21m
FlixBus	26h 45m	9:55 PM	San Antonio, TX	Bus Station	1:40 AM	Louisville, KY	Greyhound Bus Station	Economy	$106	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 10/23/2026 9:55:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/25/2026 1:40:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 26h 45m
FlixBus	33h 15m	7:45 AM	San Antonio, TX	Pearl District	6:00 PM	Louisville, KY	Greyhound Bus Station	Economy	$119	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 10/23/2026 7:45:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/24/2026 6:00:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 33h 15m
Greyhound US	23h 10m	1:30 AM	San Antonio, TX	Bus Station	1:40 AM	Louisville, KY	Greyhound Bus Station	Economy	$121	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 10/23/2026 1:30:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/24/2026 1:40:00 AM. 50 Economy ticket for $121 per person are available. Travel duration is 23h 10m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	23h 10m	1:30 AM	San Antonio, TX	Bus Station	1:40 AM	Louisville, KY	Greyhound Bus Station	Economy	$113	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 10/24/2026 1:30:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/25/2026 1:40:00 AM. 50 Economy ticket for $113 per person are available. Travel duration is 23h 10m
Greyhound US	25h 21m	11:59 AM	San Antonio, TX	Bus Station	2:20 PM	Louisville, KY	Greyhound Bus Station	Economy	$113	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 10/24/2026 11:59:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/25/2026 2:20:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 25h 21m
Greyhound US	23h 15m	4:20 AM	San Antonio, TX	Bus Station	4:35 AM	Louisville, KY	Greyhound Bus Station	Economy	$114	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 10/24/2026 4:20:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/25/2026 4:35:00 AM. 50 Economy ticket for $114 per person are available. Travel duration is 23h 15m
FlixBus	41h 50m	9:45 AM	San Antonio, TX	Pearl District	4:35 AM	Louisville, KY	Greyhound Bus Station	Economy	$116	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 10/24/2026 9:45:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/26/2026 4:35:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 41h 50m
FlixBus	33h 15m	7:45 AM	San Antonio, TX	Pearl District	6:00 PM	Louisville, KY	Greyhound Bus Station	Economy	$121	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 10/24/2026 7:45:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/25/2026 6:00:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 33h 15m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound Lines Mexico	23h 15m	4:20 AM	San Antonio, TX	Bus Station	4:35 AM	Louisville, KY	Greyhound Bus Station	Economy	$115	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 10/25/2026 4:20:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/26/2026 4:35:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 23h 15m
Greyhound Lines Mexico	25h 21m	11:59 AM	San Antonio, TX	Bus Station	2:20 PM	Louisville, KY	Greyhound Bus Station	Economy	$117	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 10/25/2026 11:59:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/26/2026 2:20:00 PM. 50 Economy ticket for $117 per person are available. Travel duration is 25h 21m
FlixBus	41h 50m	9:45 AM	San Antonio, TX	Pearl District	4:35 AM	Louisville, KY	Greyhound Bus Station	Economy	$117	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 10/25/2026 9:45:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/27/2026 4:35:00 AM. 50 Economy ticket for $117 per person are available. Travel duration is 41h 50m
Greyhound Lines Mexico	23h 10m	1:30 AM	San Antonio, TX	Bus Station	1:40 AM	Louisville, KY	Greyhound Bus Station	Economy	$124	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 10/25/2026 1:30:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/26/2026 1:40:00 AM. 50 Economy ticket for $124 per person are available. Travel duration is 23h 10m
FlixBus	33h 15m	7:45 AM	San Antonio, TX	Pearl District	6:00 PM	Louisville, KY	Greyhound Bus Station	Economy	$129	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 10/25/2026 7:45:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/26/2026 6:00:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 33h 15m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	23h 10m	1:30 AM	San Antonio, TX	Bus Station	1:40 AM	Louisville, KY	Greyhound Bus Station	Economy	$106	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 10/27/2026 1:30:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/28/2026 1:40:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 23h 10m
Greyhound US	28h 20m	4:20 AM	San Antonio, TX	Bus Station	9:40 AM	Louisville, KY	Greyhound Bus Station	Economy	$106	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 10/27/2026 4:20:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/28/2026 9:40:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 28h 20m
Greyhound US	25h 21m	11:59 AM	San Antonio, TX	Bus Station	2:20 PM	Louisville, KY	Greyhound Bus Station	Economy	$106	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 10/27/2026 11:59:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/28/2026 2:20:00 PM. 50 Economy ticket for $106 per person are available. Travel duration is 25h 21m
FlixBus	26h 45m	9:55 PM	San Antonio, TX	Bus Station	1:40 AM	Louisville, KY	Greyhound Bus Station	Economy	$106	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 10/27/2026 9:55:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/29/2026 1:40:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 26h 45m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound Lines Mexico	23h 10m	1:30 AM	San Antonio, TX	Bus Station	1:40 AM	Louisville, KY	Greyhound Bus Station	Economy	$117	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 10/28/2026 1:30:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/29/2026 1:40:00 AM. 50 Economy ticket for $117 per person are available. Travel duration is 23h 10m
Greyhound Lines Mexico	28h 20m	4:20 AM	San Antonio, TX	Bus Station	9:40 AM	Louisville, KY	Greyhound Bus Station	Economy	$117	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 10/28/2026 4:20:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/29/2026 9:40:00 AM. 50 Economy ticket for $117 per person are available. Travel duration is 28h 20m
Greyhound Lines Mexico	25h 21m	11:59 AM	San Antonio, TX	Bus Station	2:20 PM	Louisville, KY	Greyhound Bus Station	Economy	$117	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 10/28/2026 11:59:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/29/2026 2:20:00 PM. 50 Economy ticket for $117 per person are available. Travel duration is 25h 21m
FlixBus	27h 40m	9:00 PM	San Antonio, TX	Bus Station	1:40 AM	Louisville, KY	Greyhound Bus Station	Economy	$117	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 10/28/2026 9:00:00 PM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/30/2026 1:40:00 AM. 50 Economy ticket for $117 per person are available. Travel duration is 27h 40m
FlixBus	43h 50m	7:45 AM	San Antonio, TX	Pearl District	4:35 AM	Louisville, KY	Greyhound Bus Station	Economy	$120	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 10/28/2026 7:45:00 AM to Greyhound Bus Station, Louisville, KY (USA) arriving at 10/30/2026 4:35:00 AM. 50 Economy ticket for $120 per person are available. Travel duration is 43h 50m

Best Price Offer: The price for the cheapest bus from San Antonio, TX to Louisville, KY is $96 on 10/26/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between San Antonio, TX and Louisville, KY

See here how frequent the connections between San Antonio, TX and Louisville, KY are, during different times and days of the week.

Tuesday is the busiest day, with more than 8 daily buses from San Antonio, TX to Louisville, KY. Wednesday has instead the fewest connections, with only 5 daily coaches between San Antonio, TX and Louisville, KY.

The busiest time of the day is the Morning, with 12 buses from San Antonio, TX to Louisville, KY, while Evening sees the fewest connections between San Antonio, TX and Louisville, KY, with 6 offers.

Facts about the bus from San Antonio, TX to Louisville, KY

Compare all providers like FlixBus, Greyhound US and Greyhound Lines Mexico that travel 6 times every day by bus from San Antonio, TX to Louisville, KY in one click! Book your bus ticket from San Antonio, TX to Louisville, KY starting from $96!

Cheapest Bus	$96
Fastest Bus	24h 10m
Earliest Bus	1:30 AM
Latest Bus	9:00 PM
Daily Bus Routes	6 Ø
Distance	949.9 miles
Bus Companies	FlixBus, Greyhound US and Greyhound Lines Mexico

Cheapest bus connections from San Antonio, TX to Louisville, KY

Every day, 6 buses from 3 bus companies leave San Antonio, TX for Louisville, KY: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 10/23/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 10/18

Monday 10/19

Tuesday 10/20

Wednesday 10/21

Thursday 10/22

Friday 10/23

$104

Saturday 10/24

$113

Sunday 10/25

$115

Monday 10/26

$96

Tuesday 10/27

$98

Wednesday 10/28

$117

Thursday 10/29

Friday 10/30

$128

Saturday 10/31

$128

Sunday 11/01

Monday 11/02

$113

Tuesday 11/03

$110

Wednesday 11/04

Thursday 11/05

$107

Friday 11/06

Saturday 11/07

Sunday 11/08

$110

Monday 11/09

$115

Tuesday 11/10

Wednesday 11/11

$127

Thursday 11/12

$104

Friday 11/13

Saturday 11/14

The cheapest time to travel from San Antonio, TX to Louisville, KY

See here on which day and which time of the day you can find the cheapest bus ticket from San Antonio, TX to Louisville, KY, for the next 30 days.

With a price starting from $98, Tuesday is the cheapest day for a bus from San Antonio, TX to Louisville, KY. Wednesday instead is the most expensive day with prices starting from $117.

Night is the cheapest day time for bus tickets from San Antonio, TX to Louisville, KY, with $96. Morning is the most expensive time of the day with prices starting from $106.

How to save money travelling from San Antonio, TX to Louisville, KY

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Antonio, TX to Louisville, KY in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Antonio, TX to Louisville, KY, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Antonio, TX to Louisville, KY are also emptier.

Beloved bus companies from San Antonio, TX to Louisville, KY

These are the most booked bus companies between San Antonio, TX to Louisville, KY from our users.

Greyhound US from San Antonio, TX to Louisville, KY

Here you will find the key facts about the Greyhound US bus route San Antonio, TX to Louisville, KY:

Cheapest Price	$104
Fastest Bus	24h 10m
Earliest Bus	1:30 AM
Last Bus	11:59 AM
Daily Connections	3 Ø
Found on	10/21/2026

All bus stations and stops in San Antonio, TX and Louisville, KY

In the map below, you can see where to find all bus stations in San Antonio, TX and Louisville, KY.

Bus Station

N St Mary's St 500

San Antonio

Pearl District

Avenue A 699-599

Commerce & Bowie Bus Stop

W. Southcross & Buffalo Bus Stop

Greyhound Bus Station

W Muhammad Ali Blvd 720

Convention Center

S 3rd St 300

BP Gas Station

Newburg Rd 3301

W Muhammad Ali Blvd

East Broadway, under the I-65 overpass between S 1st Street and S Brook Street

International Airport

Service and Comfort on the bus from San Antonio, TX to Louisville, KY

Want to know which seat classes are available on the buses from San Antonio, TX to Louisville, KY? Or which bus companies serve the route San Antonio, TX to Louisville, KY? Below you will find answers to your questions.

FAQs about the San Antonio, TX to Louisville, KY bus

How much does a San Antonio, TX Louisville, KY bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $96 and takes 24h 15m to reach Louisville, KY. Compare offers to save money!

How much could I save by comparing buses from San Antonio, TX to Louisville, KY?

This route is offered by 3 companies with a range of ticket prices between $96 and $136. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Louisville, KY.

On average, how many connections are available from San Antonio, TX to Louisville, KY each day?

Every day, the San Antonio, TX to Louisville, KY bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Antonio, TX to Louisville, KY take?

The fastest bus from San Antonio, TX to Louisville, KY is offered by Greyhound US and takes 24h 10m. Bus tickets for this connection cost $121. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Antonio, TX to Louisville, KY?

The earliest bus arriving in Louisville, KY from San Antonio, TX starts at 1:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Antonio, TX to Louisville, KY?

The latest bus trip departing from San Antonio, TX for Louisville, KY starts at 9:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Antonio, TX Louisville, KY route?

When traveling by bus from San Antonio, TX to Louisville, KY, passengers can travel with FlixBus, Greyhound US and Greyhound Lines Mexico. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Antonio, TX and Louisville, KY?

You can check all the direct connections between San Antonio, TX and Louisville, KY by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, Greyhound US and Greyhound Lines Mexico.

What can I take with me on the San Antonio, TX to Louisville, KY bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Antonio, TX Louisville, KY bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Antonio, TX Louisville, KY bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Antonio, TX to Louisville, KY on your planned travel date.

How does CheckMyBus find the best bus deals from San Antonio, TX to Louisville, KY?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 6 daily trips between San Antonio, TX and Louisville, KY. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Antonio, TX to Louisville, KY?

Prices and availability for 6 trips between San Antonio, TX and Louisville, KY change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Antonio, TX to Louisville, KY

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Antonio, TX and to Louisville, KY

Here’s an overview of the most popular bus routes to San Antonio, TX and to Louisville, KY. Simply click on the connection of your choice, and you will find all the details about your bus route!