Bus Rome to Isernia: Compare prices and save money

Compare all timetables for the bus from Rome to Isernia

Here is a selection of the cheapest bus trips from the schedule from Rome to Isernia from various bus operators like Trenitalia, FlixBus or MarinoBus for the next days.

today

$10

tomorrow

$19

Friday

$16

Saturday

Sunday

$18

Monday

Tuesday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
MarinoBus	2h 30m	4:30 PM	Rome	Tiburtina Bus Station	7:00 PM	Isernia	Central Bus Station	Economy	$10	A Bus from MarinoBus goes from Tiburtina Bus Station, Rome (Italy) at 8/26/2026 4:30:00 PM to Central Bus Station, Isernia (Italy) arriving at 8/26/2026 7:00:00 PM. 50 Economy ticket for $10 per person are available. Travel duration is 2h 30m
FlixBus	2h 25m	2:50 PM	Rome	Tiburtina Bus Station	5:15 PM	Isernia	Central Bus Station	Economy	$16	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 8/26/2026 2:50:00 PM to Central Bus Station, Isernia (Italy) arriving at 8/26/2026 5:15:00 PM. 50 Economy ticket for $16 per person are available. Travel duration is 2h 25m
Trenitalia	2h 20m	8:15 PM	Rome	Termini Bus Station	10:35 PM	Isernia	Central Bus Station	Economy	$20	A Bus from Trenitalia goes from Termini Bus Station, Rome (Italy) at 8/26/2026 8:15:00 PM to Central Bus Station, Isernia (Italy) arriving at 8/26/2026 10:35:00 PM. 50 Economy ticket for $20 per person are available. Travel duration is 2h 20m
Trenitalia	2h 15m	5:40 PM	Rome	Tiburtina Train Station	7:55 PM	Isernia	Central Bus Station	Economy	$25	A Bus from Trenitalia goes from Tiburtina Train Station, Rome (Italy) at 8/26/2026 5:40:00 PM to Central Bus Station, Isernia (Italy) arriving at 8/26/2026 7:55:00 PM. 50 Economy ticket for $25 per person are available. Travel duration is 2h 15m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
MarinoBus	2h 30m	4:30 PM	Rome	Tiburtina Bus Station	7:00 PM	Isernia	Central Bus Station	Economy	$19	A Bus from MarinoBus goes from Tiburtina Bus Station, Rome (Italy) at 8/27/2026 4:30:00 PM to Central Bus Station, Isernia (Italy) arriving at 8/27/2026 7:00:00 PM. 50 Economy ticket for $19 per person are available. Travel duration is 2h 30m
Trenitalia	2h 20m	8:15 PM	Rome	Termini Bus Station	10:35 PM	Isernia	Central Bus Station	Economy	$20	A Bus from Trenitalia goes from Termini Bus Station, Rome (Italy) at 8/27/2026 8:15:00 PM to Central Bus Station, Isernia (Italy) arriving at 8/27/2026 10:35:00 PM. 50 Economy ticket for $20 per person are available. Travel duration is 2h 20m
Trenitalia	2h 15m	5:40 PM	Rome	Tiburtina Train Station	7:55 PM	Isernia	Central Bus Station	Economy	$25	A Bus from Trenitalia goes from Tiburtina Train Station, Rome (Italy) at 8/27/2026 5:40:00 PM to Central Bus Station, Isernia (Italy) arriving at 8/27/2026 7:55:00 PM. 50 Economy ticket for $25 per person are available. Travel duration is 2h 15m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	2h 25m	2:50 PM	Rome	Tiburtina Bus Station	5:15 PM	Isernia	Central Bus Station	Economy	$16	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 8/28/2026 2:50:00 PM to Central Bus Station, Isernia (Italy) arriving at 8/28/2026 5:15:00 PM. 50 Economy ticket for $16 per person are available. Travel duration is 2h 25m
Trenitalia	2h 20m	8:15 PM	Rome	Termini Bus Station	10:35 PM	Isernia	Central Bus Station	Economy	$20	A Bus from Trenitalia goes from Termini Bus Station, Rome (Italy) at 8/28/2026 8:15:00 PM to Central Bus Station, Isernia (Italy) arriving at 8/28/2026 10:35:00 PM. 50 Economy ticket for $20 per person are available. Travel duration is 2h 20m
MarinoBus	2h 30m	4:30 PM	Rome	Tiburtina Bus Station	7:00 PM	Isernia	Central Bus Station	Economy	$21	A Bus from MarinoBus goes from Tiburtina Bus Station, Rome (Italy) at 8/28/2026 4:30:00 PM to Central Bus Station, Isernia (Italy) arriving at 8/28/2026 7:00:00 PM. 50 Economy ticket for $21 per person are available. Travel duration is 2h 30m
Trenitalia	2h 15m	5:40 PM	Rome	Tiburtina Train Station	7:55 PM	Isernia	Central Bus Station	Economy	$25	A Bus from Trenitalia goes from Tiburtina Train Station, Rome (Italy) at 8/28/2026 5:40:00 PM to Central Bus Station, Isernia (Italy) arriving at 8/28/2026 7:55:00 PM. 50 Economy ticket for $25 per person are available. Travel duration is 2h 15m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
MarinoBus	2h 30m	4:30 PM	Rome	Tiburtina Bus Station	7:00 PM	Isernia	Central Bus Station	Economy	$6	A Bus from MarinoBus goes from Tiburtina Bus Station, Rome (Italy) at 8/29/2026 4:30:00 PM to Central Bus Station, Isernia (Italy) arriving at 8/29/2026 7:00:00 PM. 50 Economy ticket for $6 per person are available. Travel duration is 2h 30m
FlixBus	2h 25m	2:50 PM	Rome	Tiburtina Bus Station	5:15 PM	Isernia	Central Bus Station	Economy	$16	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 8/29/2026 2:50:00 PM to Central Bus Station, Isernia (Italy) arriving at 8/29/2026 5:15:00 PM. 50 Economy ticket for $16 per person are available. Travel duration is 2h 25m
Trenitalia	2h 20m	6:15 AM	Rome	Termini Bus Station	8:35 AM	Isernia	Central Bus Station	Economy	$19	A Bus from Trenitalia goes from Termini Bus Station, Rome (Italy) at 8/29/2026 6:15:00 AM to Central Bus Station, Isernia (Italy) arriving at 8/29/2026 8:35:00 AM. 50 Economy ticket for $19 per person are available. Travel duration is 2h 20m
Trenitalia	2h 18m	9:07 AM	Rome	Termini Bus Station	11:25 AM	Isernia	Central Bus Station	Economy	$19	A Bus from Trenitalia goes from Termini Bus Station, Rome (Italy) at 8/29/2026 9:07:00 AM to Central Bus Station, Isernia (Italy) arriving at 8/29/2026 11:25:00 AM. 50 Economy ticket for $19 per person are available. Travel duration is 2h 18m

Cheapest bus trips Sunday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	2h 25m	2:50 PM	Rome	Tiburtina Bus Station	5:15 PM	Isernia	Central Bus Station		Economy	$18	A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 8/30/2026 2:50:00 PM to Central Bus Station, Isernia (Italy) arriving at 8/30/2026 5:15:00 PM. 50 Economy ticket for $18 per person are available. Travel duration is 2h 25m

Best Price Offer: The price for the cheapest bus from Rome to Isernia is $6 on 8/29/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Rome and Isernia

See here how frequent the connections between Rome and Isernia are, during different times and days of the week.

Saturday is the busiest day, with more than 8 daily buses from Rome to Isernia. Sunday has instead the fewest connections, with only 1 daily coaches between Rome and Isernia.

The busiest time of the day is the Afternoon, with 14 buses from Rome to Isernia, while Morning sees the fewest connections between Rome and Isernia, with 2 offers.

Facts about the bus from Rome to Isernia

Compare all providers like Trenitalia, FlixBus and MarinoBus that travel 4 times every day by bus from Rome to Isernia in one click! Book your bus ticket from Rome to Isernia starting from $6!

Cheapest Bus	$6
Fastest Bus	2h 15m
Earliest Bus	2:50 PM
Latest Bus	2:50 PM
Daily Bus Routes	4 Ø
Distance	91.9 miles
Bus Companies	Trenitalia, FlixBus and MarinoBus

Cheapest bus connections from Rome to Isernia

Every day, 4 buses from 3 bus companies leave Rome for Isernia: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 08/26/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 08/23

Monday 08/24

Tuesday 08/25

Wednesday 08/26

$20

Thursday 08/27

$16

Friday 08/28

$16

Saturday 08/29

Sunday 08/30

$18

Monday 08/31

Tuesday 09/01

$15

Wednesday 09/02

$15

Thursday 09/03

$15

Friday 09/04

$16

Saturday 09/05

$15

Sunday 09/06

$22

Monday 09/07

$14

Tuesday 09/08

$13

Wednesday 09/09

$15

Thursday 09/10

$15

Friday 09/11

$18

Saturday 09/12

$16

Sunday 09/13

$16

Monday 09/14

$16

Tuesday 09/15

$13

Wednesday 09/16

$14

Thursday 09/17

$12

Friday 09/18

$15

Saturday 09/19

The cheapest time to travel from Rome to Isernia

See here on which day and which time of the day you can find the cheapest bus ticket from Rome to Isernia, for the next 30 days.

With a price starting from $6, Saturday is the cheapest day for a bus from Rome to Isernia. Friday instead is the most expensive day with prices starting from $15.

Afternoon is the cheapest day time for bus tickets from Rome to Isernia, with $6. Evening is the most expensive time of the day with prices starting from $19.

How to save money travelling from Rome to Isernia

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Rome to Isernia in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Rome to Isernia, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Rome to Isernia are also emptier.

All bus stations and stops in Rome and Isernia

In the map below, you can see where to find all bus stations in Rome and Isernia.

Anagnina Bus Station

Piazzale della Stazione Anagnina

Termini Bus Station

Piazza dei Cinquecento 64

Tiburtina Bus Station

Tiburtina Partenze

Vatican City

Via Crescenzio 19

Central Bus Station

Service and Comfort on the bus from Rome to Isernia

Want to know which seat classes are available on the buses from Rome to Isernia? Or which bus companies serve the route Rome to Isernia? Below you will find answers to your questions.

FAQs about the Rome to Isernia bus

How much does a Rome Isernia bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $6 and takes 2h 30m to reach Isernia. Compare offers to save money!

How much could I save by comparing buses from Rome to Isernia?

This route is offered by 3 companies with a range of ticket prices between $6 and $25. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Isernia.

On average, how many connections are available from Rome to Isernia each day?

Every day, the Rome to Isernia bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Rome to Isernia take?

The fastest bus from Rome to Isernia is offered by Trenitalia and takes 2h 15m. Bus tickets for this connection cost $25. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Rome to Isernia?

The earliest bus arriving in Isernia from Rome starts at 2:50 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Rome to Isernia?

The latest bus trip departing from Rome for Isernia starts at 2:50 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Rome Isernia route?

When traveling by bus from Rome to Isernia, passengers can travel with Trenitalia, FlixBus and MarinoBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Rome and Isernia?

You can check all the direct connections between Rome and Isernia by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Trenitalia, FlixBus and MarinoBus.

What can I take with me on the Rome to Isernia bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Rome Isernia bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Rome Isernia bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Rome to Isernia on your planned travel date.

How does CheckMyBus find the best bus deals from Rome to Isernia?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Rome and Isernia. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Rome to Isernia?

Prices and availability for 4 trips between Rome and Isernia change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Rome to Isernia

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Rome and to Isernia

Here’s an overview of the most popular bus routes to Rome and to Isernia. Simply click on the connection of your choice, and you will find all the details about your bus route!