Bus from Orlando, FL to Florence, SC from $53

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Compare all timetables for the bus from Orlando, FL to Florence, SC

Here is a selection of the cheapest bus trips from the schedule from Orlando, FL to Florence, SC from various bus operators like FlixBus for the next days.

today
$83
tomorrow
Sunday
Monday
Tuesday
Wednesday
Thursday
$76

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 16h 15m 10:55 PM Orlando, FL Bus Station 3:10 PM Florence, SC Bus Station  Economy $83
FlixBus 24h 45m 12:45 PM Orlando, FL Florida Mall 1:30 PM Florence, SC Bus Station  Economy $84
FlixBus 25h 10m 2:00 PM Orlando, FL Florida Mall 3:10 PM Florence, SC Bus Station  Economy $84
FlixBus 21h 25m 2:30 PM Orlando, FL Bus Station 11:55 AM Florence, SC Bus Station  Economy $84
FlixBus 16h 40m 8:50 PM Orlando, FL Bus Station 1:30 PM Florence, SC Bus Station  Economy $120
  • Did you know that if you travel from Orlando, FL to Florence, SC via Jacksonville, FL, you can save more than $18? You can find the corresponding connections below.
    • FlixBus
      18h 5m
      0
      6:00 AM
      Orlando, FL
      Bus Station
      8:50 AM
      Jacksonville, FL
      Downtown Bus Stop
      0
      FlixBus
      Economy
      $20
      • Waiting Time 9h 40m
    • FlixBus
      5h 35m
      0
      6:30 PM
      Jacksonville, FL
      Amtrak Train Station
      12:05 AM
      Florence, SC
      TA Travel Center
      0
      FlixBus
      Economy
      $45
    Travel time is 1h 50m longer, but you will save $18

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 21h 25m 2:30 PM Orlando, FL Bus Station 11:55 AM Florence, SC Bus Station  Economy $76
FlixBus 24h 45m 12:45 PM Orlando, FL Florida Mall 1:30 PM Florence, SC Bus Station  Economy $77
FlixBus 16h 15m 10:55 PM Orlando, FL Bus Station 3:10 PM Florence, SC Bus Station  Economy $79
FlixBus 16h 40m 8:50 PM Orlando, FL Bus Station 1:30 PM Florence, SC Bus Station  Economy $86
  • Did you know that if you travel from Orlando, FL to Florence, SC via Jacksonville, FL, you can save more than $11? You can find the corresponding connections below.
    • FlixBus
      18h 5m
      0
      6:00 AM
      Orlando, FL
      Bus Station
      8:50 AM
      Jacksonville, FL
      Downtown Bus Stop
      0
      FlixBus
      Economy
      $20
      • Waiting Time 9h 40m
    • FlixBus
      5h 35m
      0
      6:30 PM
      Jacksonville, FL
      Amtrak Train Station
      12:05 AM
      Florence, SC
      TA Travel Center
      0
      FlixBus
      Economy
      $45
    Travel time is 1h 50m longer, but you will save $11

Best Price Offer: The price for the cheapest bus from Orlando, FL to Florence, SC is $53 on 11/5/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Orlando, FL and Florence, SC

See here how frequent the connections between Orlando, FL and Florence, SC are, during different times and days of the week.
Friday is the busiest day, with more than 5 daily buses from Orlando, FL to Florence, SC. Thursday has instead the fewest connections, with only 4 daily coaches between Orlando, FL and Florence, SC.
The busiest time of the day is the Afternoon, with 5 buses from Orlando, FL to Florence, SC, while Evening sees the fewest connections between Orlando, FL and Florence, SC, with 4 offers.

Facts about the bus from Orlando, FL to Florence, SC

Compare all providers like FlixBus that travel 4 times every day by bus from Orlando, FL to Florence, SC in one click! Book your bus ticket from Orlando, FL to Florence, SC starting from $53!

Cheapest Bus $53
Fastest Bus 16h 15m
Earliest Bus 12:45 PM
Latest Bus 10:55 PM
Daily Bus Routes 4 Ø
Distance 402.2 miles
Bus Companies FlixBus

Cheapest bus connections from Orlando, FL to Florence, SC

Every day, 4 buses from 1 bus companies leave Orlando, FL for Florence, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 10/23/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 10/18
Monday 10/19
Tuesday 10/20
Wednesday 10/21
Thursday 10/22
Friday 10/23
$60
Saturday 10/24
Sunday 10/25
Monday 10/26
Tuesday 10/27
Wednesday 10/28
Thursday 10/29
$55
Friday 10/30
Saturday 10/31
$57
Sunday 11/01
Monday 11/02
$66
Tuesday 11/03
Wednesday 11/04
Thursday 11/05
$53
Friday 11/06
Saturday 11/07
$64
Sunday 11/08
$66
Monday 11/09
$64
Tuesday 11/10
Wednesday 11/11
Thursday 11/12
$66
Friday 11/13
Saturday 11/14

The cheapest time to travel from Orlando, FL to Florence, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Orlando, FL to Florence, SC, for the next 30 days.
With a price starting from $53, Thursday is the cheapest day for a bus from Orlando, FL to Florence, SC. Friday instead is the most expensive day with prices starting from $60.
Afternoon is the cheapest day time for bus tickets from Orlando, FL to Florence, SC, with $76. Evening is the most expensive time of the day with prices starting from $79.

How to save money travelling from Orlando, FL to Florence, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Orlando, FL to Florence, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Orlando, FL to Florence, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Orlando, FL to Florence, SC are also emptier.

Beloved bus companies from Orlando, FL to Florence, SC

These are the most booked bus companies between Orlando, FL to Florence, SC from our users.

FlixBus from Orlando, FL to Florence, SC

FlixBus

Here you will find the key facts about the FlixBus bus route Orlando, FL to Florence, SC:

Cheapest Price $76
Fastest Bus 16h 15m
Earliest Bus 12:45 PM
Last Bus 10:55 PM
Daily Connections 4 Ø
Found on 9/29/2026

All bus stations and stops in Orlando, FL and Florence, SC

In the map below, you can see where to find all bus stations in Orlando, FL and Florence, SC.

Service and Comfort on the bus from Orlando, FL to Florence, SC

Want to know which seat classes are available on the buses from Orlando, FL to Florence, SC? Or which bus companies serve the route Orlando, FL to Florence, SC? Below you will find answers to your questions.

FAQs about the Orlando, FL to Florence, SC bus

How much does a Orlando, FL Florence, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $53 and takes 21h 25m to reach Florence, SC. Compare offers to save money!

How much could I save by comparing buses from Orlando, FL to Florence, SC?

This route is offered by 1 companies with a range of ticket prices between $53 and $120. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Florence, SC.

On average, how many connections are available from Orlando, FL to Florence, SC each day?

Every day, the Orlando, FL to Florence, SC bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Orlando, FL to Florence, SC take?

The fastest bus from Orlando, FL to Florence, SC is offered by FlixBus and takes 16h 15m. Bus tickets for this connection cost $83. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Orlando, FL to Florence, SC?

The earliest bus arriving in Florence, SC from Orlando, FL starts at 12:45 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Orlando, FL to Florence, SC?

The latest bus trip departing from Orlando, FL for Florence, SC starts at 10:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Orlando, FL Florence, SC route?

When traveling by bus from Orlando, FL to Florence, SC, passengers can travel with FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Orlando, FL and Florence, SC?

You can check all the direct connections between Orlando, FL and Florence, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the Orlando, FL to Florence, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Orlando, FL Florence, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Orlando, FL Florence, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Orlando, FL to Florence, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Orlando, FL to Florence, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Orlando, FL and Florence, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Orlando, FL to Florence, SC?

Prices and availability for 4 trips between Orlando, FL and Florence, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Orlando, FL to Florence, SC

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Orlando, FL and to Florence, SC

Here’s an overview of the most popular bus routes to Orlando, FL and to Florence, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Bus to Florence, SC from Monroe, GA Bus to Florence, SC from Monroe, GA
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Popular Airport Shuttles to Orlando, FL and to Florence, SC
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