Bus La Serena to Santiago, RM - Compare all Companies

Compare all timetables for the bus from La Serena to Santiago, RM

Here is a selection of the cheapest bus trips from the schedule from La Serena to Santiago, RM from various bus operators like Pluss Chile, Cikbus Elité or Turbus for the next days.

today

$11

tomorrow

$11

Saturday

$13

Sunday

$13

Monday

Tuesday

$11

Wednesday

$11

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Pluss Chile	6h 30m	4:46 AM	La Serena	Central Bus Station	11:16 AM	Santiago, RM	Sur Bus Station	Premium Economy	$11	A Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 8/27/2026 4:46:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/27/2026 11:16:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 30m
Buses Romani	6h 0m	9:00 AM	La Serena	Central Bus Station	3:00 PM	Santiago, RM	Sur Bus Station	Premium Economy	$11	A Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 8/27/2026 9:00:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/27/2026 3:00:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 0m
FlixBus	6h 5m	3:15 PM	La Serena	Central Bus Station	9:20 PM	Santiago, RM	Terminal San Borja	Economy	$13	A Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 8/27/2026 3:15:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/27/2026 9:20:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 6h 5m
Turbus	7h 30m	9:50 AM	La Serena	Avda. Fco de Aguirre Station	5:20 PM	Santiago, RM	Terminal San Borja	Premium Economy	$14	A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 8/27/2026 9:50:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/27/2026 5:20:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 7h 30m
Cormar Bus	6h 30m	11:30 PM	La Serena	Central Bus Station	6:00 AM	Santiago, RM	Terminal San Borja	Premium Economy	$15	A Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 8/27/2026 11:30:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/28/2026 6:00:00 AM. 50 Premium Economy ticket for $15 per person are available. Travel duration is 6h 30m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Pluss Chile	6h 40m	12:05 AM	La Serena	Central Bus Station	6:45 AM	Santiago, RM	Sur Bus Station	Premium Economy	$11	A Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 8/28/2026 12:05:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/28/2026 6:45:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 40m
Buses Romani	6h 30m	12:45 AM	La Serena	Central Bus Station	7:15 AM	Santiago, RM	Sur Bus Station	Premium Economy	$11	A Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 8/28/2026 12:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/28/2026 7:15:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 30m
Cikbus Elité	6h 45m	4:45 AM	La Serena	Central Bus Station	11:30 AM	Santiago, RM	Sur Bus Station	Premium Economy	$13	A Bus from Cikbus Elité goes from Central Bus Station, La Serena (Chile) at 8/28/2026 4:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/28/2026 11:30:00 AM. 50 Premium Economy ticket for $13 per person are available. Travel duration is 6h 45m
FlixBus	6h 0m	11:50 PM	La Serena	Central Bus Station	5:50 AM	Santiago, RM	Terminal San Borja	Economy	$13	A Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 8/28/2026 11:50:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/29/2026 5:50:00 AM. 50 Economy ticket for $13 per person are available. Travel duration is 6h 0m
Turbus	6h 15m	5:35 AM	La Serena	Avda. Fco de Aguirre Station	11:50 AM	Santiago, RM	Terminal Alameda	Premium Economy	$14	A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 8/28/2026 5:35:00 AM to Terminal Alameda, Santiago, RM (Chile) arriving at 8/28/2026 11:50:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 15m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Pluss Chile	6h 30m	2:30 AM	La Serena	Central Bus Station	9:00 AM	Santiago, RM	Sur Bus Station	Premium Economy	$13	A Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 8/29/2026 2:30:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/29/2026 9:00:00 AM. 50 Premium Economy ticket for $13 per person are available. Travel duration is 6h 30m
FlixBus	6h 0m	11:50 PM	La Serena	Central Bus Station	5:50 AM	Santiago, RM	Terminal San Borja	Economy	$13	A Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 8/29/2026 11:50:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/30/2026 5:50:00 AM. 50 Economy ticket for $13 per person are available. Travel duration is 6h 0m
Condor Bus	7h 10m	9:45 PM	La Serena	Central Bus Station	4:55 AM	Santiago, RM	Sur Bus Station	Premium Economy	$14	A Bus from Condor Bus goes from Central Bus Station, La Serena (Chile) at 8/29/2026 9:45:00 PM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/30/2026 4:55:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 7h 10m
Turbus	6h 15m	4:50 AM	La Serena	Avda. Fco de Aguirre Station	11:05 AM	Santiago, RM	Terminal Alameda	Premium Economy	$14	A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 8/29/2026 4:50:00 AM to Terminal Alameda, Santiago, RM (Chile) arriving at 8/29/2026 11:05:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 15m
Pullman Bus	6h 0m	12:45 AM	La Serena	El Sto, 1060	6:45 AM	Santiago, RM	Terminal San Borja	First Class	$15	A Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 8/29/2026 12:45:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/29/2026 6:45:00 AM. 50 First Class ticket for $15 per person are available. Travel duration is 6h 0m

Did you know that if you travel from La Serena to Santiago, RM via Coquimbo, you can save more than $2? You will find the corresponding connections below.
- Save more than 15%
  
  6h 0m
  
  La Serena
  
  7 mi
  
  1:15 AM
  
  Coquimbo
  Bus Station
  
  7:15 AM
  
  Santiago, RM
  Sur Bus Station
  
  0 mi
  
  Premium Economy
  
  $11
  
  A Bus from goes from Bus Station, Coquimbo (Chile) at 8/29/2026 1:15:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/29/2026 7:15:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 0m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Pluss Chile	6h 30m	2:30 AM	La Serena	Central Bus Station	9:00 AM	Santiago, RM	Sur Bus Station	Premium Economy	$13	A Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 8/30/2026 2:30:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/30/2026 9:00:00 AM. 50 Premium Economy ticket for $13 per person are available. Travel duration is 6h 30m
Cikbus Elité	6h 30m	6:20 AM	La Serena	Central Bus Station	12:50 PM	Santiago, RM	Sur Bus Station	Premium Economy	$13	A Bus from Cikbus Elité goes from Central Bus Station, La Serena (Chile) at 8/30/2026 6:20:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/30/2026 12:50:00 PM. 50 Premium Economy ticket for $13 per person are available. Travel duration is 6h 30m
FlixBus	6h 0m	11:50 PM	La Serena	Central Bus Station	5:50 AM	Santiago, RM	Terminal San Borja	Economy	$14	A Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 8/30/2026 11:50:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/31/2026 5:50:00 AM. 50 Economy ticket for $14 per person are available. Travel duration is 6h 0m
Turbus	6h 5m	6:55 AM	La Serena	Avda. Fco de Aguirre Station	1:00 PM	Santiago, RM	Terminal Alameda	Premium Economy	$14	A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 8/30/2026 6:55:00 AM to Terminal Alameda, Santiago, RM (Chile) arriving at 8/30/2026 1:00:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 5m
Pullman Bus	6h 30m	2:00 AM	La Serena	El Sto, 1060	8:30 AM	Santiago, RM	Terminal San Borja	First Class	$15	A Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 8/30/2026 2:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/30/2026 8:30:00 AM. 50 First Class ticket for $15 per person are available. Travel duration is 6h 30m

Did you know that if you travel from La Serena to Santiago, RM via Coquimbo, you can save more than $1? You will find the corresponding connections below.
- Save more than 8%
  
  5h 30m
  
  La Serena
  
  7 mi
  
  9:30 AM
  
  Coquimbo
  Escuela Hogar Bus Stop
  
  3:00 PM
  
  Santiago, RM
  Terminal San Borja
  
  0 mi
  
  Premium Economy
  
  $12
  
  A Bus from goes from Escuela Hogar Bus Stop, Coquimbo (Chile) at 8/30/2026 9:30:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/30/2026 3:00:00 PM. 50 Premium Economy ticket for $12 per person are available. Travel duration is 5h 30m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Pluss Chile	6h 30m	12:05 AM	La Serena	Central Bus Station	6:35 AM	Santiago, RM	Sur Bus Station	Premium Economy	$9	A Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 8/31/2026 12:05:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/31/2026 6:35:00 AM. 50 Premium Economy ticket for $9 per person are available. Travel duration is 6h 30m
Buses Romani	6h 30m	12:45 AM	La Serena	Central Bus Station	7:15 AM	Santiago, RM	Sur Bus Station	Premium Economy	$11	A Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 8/31/2026 12:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/31/2026 7:15:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 30m
Condor Bus	6h 15m	4:50 PM	La Serena	Central Bus Station	11:05 PM	Santiago, RM	Sur Bus Station	Premium Economy	$14	A Bus from Condor Bus goes from Central Bus Station, La Serena (Chile) at 8/31/2026 4:50:00 PM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/31/2026 11:05:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 15m
FlixBus	6h 30m	8:00 AM	La Serena	Central Bus Station	2:30 PM	Santiago, RM	Terminal San Borja	Economy	$14	A Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 8/31/2026 8:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/31/2026 2:30:00 PM. 50 Economy ticket for $14 per person are available. Travel duration is 6h 30m
Turbus	6h 15m	4:50 AM	La Serena	Avda. Fco de Aguirre Station	11:05 AM	Santiago, RM	Terminal Alameda	Premium Economy	$14	A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 8/31/2026 4:50:00 AM to Terminal Alameda, Santiago, RM (Chile) arriving at 8/31/2026 11:05:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 15m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Buses Romani	6h 15m	12:45 AM	La Serena	Central Bus Station	7:00 AM	Santiago, RM	Sur Bus Station	Premium Economy	$11	A Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 9/1/2026 12:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 9/1/2026 7:00:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 15m
Pluss Chile	6h 40m	12:05 AM	La Serena	Central Bus Station	6:45 AM	Santiago, RM	Sur Bus Station	Premium Economy	$13	A Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 9/1/2026 12:05:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 9/1/2026 6:45:00 AM. 50 Premium Economy ticket for $13 per person are available. Travel duration is 6h 40m
FlixBus	5h 59m	6:00 PM	La Serena	Central Bus Station	11:59 PM	Santiago, RM	Terminal San Borja	Economy	$13	A Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 9/1/2026 6:00:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 9/1/2026 11:59:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 5h 59m
Condor Bus	6h 35m	12:45 AM	La Serena	Central Bus Station	7:20 AM	Santiago, RM	Sur Bus Station	Premium Economy	$14	A Bus from Condor Bus goes from Central Bus Station, La Serena (Chile) at 9/1/2026 12:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 9/1/2026 7:20:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 35m
Turbus	6h 15m	2:30 AM	La Serena	Avda. Fco de Aguirre Station	8:45 AM	Santiago, RM	Terminal Alameda	Premium Economy	$14	A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 9/1/2026 2:30:00 AM to Terminal Alameda, Santiago, RM (Chile) arriving at 9/1/2026 8:45:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 15m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Buses Romani	6h 30m	12:45 AM	La Serena	Central Bus Station	7:15 AM	Santiago, RM	Sur Bus Station	Premium Economy	$11	A Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 9/2/2026 12:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 9/2/2026 7:15:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 30m
Pluss Chile	6h 40m	12:05 AM	La Serena	Central Bus Station	6:45 AM	Santiago, RM	Sur Bus Station	Premium Economy	$13	A Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 9/2/2026 12:05:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 9/2/2026 6:45:00 AM. 50 Premium Economy ticket for $13 per person are available. Travel duration is 6h 40m
FlixBus	6h 5m	3:15 PM	La Serena	Central Bus Station	9:20 PM	Santiago, RM	Terminal San Borja	Economy	$13	A Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 9/2/2026 3:15:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 9/2/2026 9:20:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 6h 5m
Condor Bus	6h 35m	12:45 AM	La Serena	Central Bus Station	7:20 AM	Santiago, RM	Sur Bus Station	Premium Economy	$14	A Bus from Condor Bus goes from Central Bus Station, La Serena (Chile) at 9/2/2026 12:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 9/2/2026 7:20:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 35m
Turbus	6h 30m	12:55 PM	La Serena	Avda. Fco de Aguirre Station	7:25 PM	Santiago, RM	Terminal Alameda	Premium Economy	$14	A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 9/2/2026 12:55:00 PM to Terminal Alameda, Santiago, RM (Chile) arriving at 9/2/2026 7:25:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 30m

Best Price Offer: The price for the cheapest bus from La Serena to Santiago, RM is $9 on 8/31/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between La Serena and Santiago, RM

See here how frequent the connections between La Serena and Santiago, RM are, during different times and days of the week.

Wednesday is the busiest day, with more than 217 daily buses from La Serena to Santiago, RM. Thursday has instead the fewest connections, with only 140 daily coaches between La Serena and Santiago, RM.

The busiest time of the day is the Night, with 401 buses from La Serena to Santiago, RM, while Evening sees the fewest connections between La Serena and Santiago, RM, with 220 offers.

Facts about the bus from La Serena to Santiago, RM

Compare all providers like Pluss Chile, Cikbus Elité and Turbus that travel 181 times every day by bus from La Serena to Santiago, RM in one click! Book your bus ticket from La Serena to Santiago, RM starting from $9!

Cheapest Bus	$9
Fastest Bus	5h 40m
Earliest Bus	4:20 AM
Latest Bus	11:59 PM
Daily Bus Routes	181 Ø
Distance	247.0 miles
Bus Companies	Pluss Chile, Cikbus Elité, Turbus, FlixBus, Pullman San Andres, Andimar, Pullman Bus, Condor Bus, Cormar Bus, Buses Romani and 2 more.

Cheapest bus connections from La Serena to Santiago, RM

Every day, 181 buses from 12 bus companies leave La Serena for Santiago, RM: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 08/27/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 08/23

Monday 08/24

Tuesday 08/25

Wednesday 08/26

Thursday 08/27

$14

Friday 08/28

$14

Saturday 08/29

$14

Sunday 08/30

$14

Monday 08/31

$14

Tuesday 09/01

$13

Wednesday 09/02

$11

Thursday 09/03

$13

Friday 09/04

$29

Saturday 09/05

$11

Sunday 09/06

$14

Monday 09/07

$18

Tuesday 09/08

$12

Wednesday 09/09

$12

Thursday 09/10

$12

Friday 09/11

$11

Saturday 09/12

$11

Sunday 09/13

$14

Monday 09/14

$16

Tuesday 09/15

$12

Wednesday 09/16

$13

Thursday 09/17

$16

Friday 09/18

$12

Saturday 09/19

The cheapest time to travel from La Serena to Santiago, RM

See here on which day and which time of the day you can find the cheapest bus ticket from La Serena to Santiago, RM, for the next 30 days.

With a price starting from $9, Monday is the cheapest day for a bus from La Serena to Santiago, RM. Sunday instead is the most expensive day with prices starting from $13.

Night is the cheapest day time for bus tickets from La Serena to Santiago, RM, with $9. Morning is the most expensive time of the day with prices starting from $11.

How to save money travelling from La Serena to Santiago, RM

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from La Serena to Santiago, RM in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from La Serena to Santiago, RM, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from La Serena to Santiago, RM are also emptier.

Beloved bus companies from La Serena to Santiago, RM

These are the most booked bus companies between La Serena to Santiago, RM from our users.

Cikbus Elité from La Serena to Santiago, RM

Here you will find the key facts about the Cikbus Elité bus route La Serena to Santiago, RM:

Cheapest Price	$13
Fastest Bus	5h 45m
Earliest Bus	4:45 AM
Last Bus	11:59 PM
Daily Connections	28 Ø
Found on	8/27/2026

Pluss Chile from La Serena to Santiago, RM

Here you will find the key facts about the Pluss Chile bus route La Serena to Santiago, RM:

Cheapest Price	$9
Fastest Bus	6h 0m
Earliest Bus	4:46 AM
Last Bus	10:20 PM
Daily Connections	32 Ø
Found on	8/27/2026

Cormar Bus from La Serena to Santiago, RM

Here you will find the key facts about the Cormar Bus bus route La Serena to Santiago, RM:

Cheapest Price	$15
Fastest Bus	5h 40m
Earliest Bus	8:10 AM
Last Bus	11:59 PM
Daily Connections	8 Ø
Found on	8/27/2026

Latest reviews for bus companies on the route La Serena - Santiago, RM

Risa Manabe , 4/17/2026

Por lo general viajamos con mi pareja de serena a Santiago y nos acomoda el terminal los libertadores En dos ocasiones hemos tenido problemas con el bus y al cambiarnos no nos dan ninguna solución p ... Por lo general viajamos con mi pareja de serena a Santiago y nos acomoda el terminal los libertadores En dos ocasiones hemos tenido problemas con el bus y al cambiarnos no nos dan ninguna solución para llegar al mismo terminal ya que por eso compramos hacia terminal los libertadores y me parece de muy mal gusto que nos coloquen en otro bus al terminal Borja ,el problema no es el bus ni que nos cambien de bus por emergencia ,el problema es que no se reubiquen a los pasajeros del bus al mismo destino que uno saca el pasaje En este caso el destino era los libertadores y a mí pareja le cambiaron el bus y lo dejaron el el terminal Borja ...es la segunda vez que ocurre

carolina saavedra, 4/14/2026

Pésimo servicio,.los auxiliares maleducados, sin aire, parecía un sauna, los auxiliares prepotentes, pésima atención

Ana Riveros, 12/17/2025

El bus salió 1 hora atrasado Debía llegara la 8.15 a Santiago Y llegara a las 10 y yo debía estar a las 9.30 por un tema médico. Esto significa que perdí mi hora y el viaje. Por culpa de su neglige ... El bus salió 1 hora atrasado Debía llegara la 8.15 a Santiago Y llegara a las 10 y yo debía estar a las 9.30 por un tema médico. Esto significa que perdí mi hora y el viaje. Por culpa de su negligencia. Estaba acostumbrada a la puntualidad que siempre entregaban.

Claudia , 10/23/2025

El bus venía de Calama y salió con una hora de retraso.

Luis ig, 10/5/2025

Viaje en salón cama de la serena a Santiago y el bus salió una hora más tarde adema la máquina estaba hedionda y el asiento de reclinaba solo y el posa piernas estaba vencido por lo que todo el viaje ... Viaje en salón cama de la serena a Santiago y el bus salió una hora más tarde adema la máquina estaba hedionda y el asiento de reclinaba solo y el posa piernas estaba vencido por lo que todo el viaje me estuvo golpeando las piernas, pésimo el viaje.

Esteban Guerrero, 1/29/2025

Compré un pasaje de 6 horas en salón premium adelante en el parabrisas no había nada de espacio. Ultima vez que viajo en plus chile

All bus stations and stops in La Serena and Santiago, RM

In the map below, you can see where to find all bus stations in La Serena and Santiago, RM.

Avda. Fco de Aguirre Station

Avenida Francisco de Aguirre 410

Central Bus Station

Avenida El Santo 1475

terminal de buses covalle bus

El Sto, 1060

Rotonda

Sur Bus Station

Av Libertador Bernardo O'Higgins 3850

Terminal San Borja

San Francisco de Borja 198-180

Terminal Pajaritos

Av. Gral. Óscar Bonilla 5935-5939

Terminal Alameda

Av Libertador Bernardo O'Higgins 3750

Los Héroes Station

Tucapel Jiménez 22

Service and Comfort on the bus from La Serena to Santiago, RM

Want to know which seat classes are available on the buses from La Serena to Santiago, RM? Or which bus companies serve the route La Serena to Santiago, RM? Below you will find answers to your questions.

FAQs about the La Serena to Santiago, RM bus

How much does a La Serena Santiago, RM bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $9 and takes 6h 30m to reach Santiago, RM. Compare offers to save money!

How much could I save by comparing buses from La Serena to Santiago, RM?

This route is offered by 12 companies with a range of ticket prices between $9 and $34. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Santiago, RM.

On average, how many connections are available from La Serena to Santiago, RM each day?

Every day, the La Serena to Santiago, RM bus route is served by approximately 181 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from La Serena to Santiago, RM take?

The fastest bus from La Serena to Santiago, RM is offered by Andimar and takes 5h 40m. Bus tickets for this connection cost $17. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from La Serena to Santiago, RM?

The earliest bus arriving in Santiago, RM from La Serena starts at 4:20 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from La Serena to Santiago, RM?

The latest bus trip departing from La Serena for Santiago, RM starts at 11:59 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the La Serena Santiago, RM route?

When traveling by bus from La Serena to Santiago, RM, passengers can travel with Pluss Chile, Cikbus Elité and Turbus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between La Serena and Santiago, RM?

You can check all the direct connections between La Serena and Santiago, RM by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Pluss Chile, Cikbus Elité and Turbus.

What can I take with me on the La Serena to Santiago, RM bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the La Serena Santiago, RM bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the La Serena Santiago, RM bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from La Serena to Santiago, RM on your planned travel date.

How does CheckMyBus find the best bus deals from La Serena to Santiago, RM?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 181 daily trips between La Serena and Santiago, RM. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from La Serena to Santiago, RM?

Prices and availability for 181 trips between La Serena and Santiago, RM change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route La Serena to Santiago, RM

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

Premium Economy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

First Class

Best of the best: you will find the most comfortable accommodation to work or relax during your travel.

More bus routes to La Serena and to Santiago, RM

Here’s an overview of the most popular bus routes to La Serena and to Santiago, RM. Simply click on the connection of your choice, and you will find all the details about your bus route!