Bus from Greenville, SC to Durham, NC from $39

Compare all the bus companies and find the best price with CheckMyBus
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from Greenville, SC to Durham, NC

Here is a selection of the cheapest bus trips from the schedule from Greenville, SC to Durham, NC from various bus operators like Wanda Coach, FlixBus or Greyhound US for the next days.

today
$50
tomorrow
$39
Saturday
$39
Sunday
$50
Monday
Tuesday
$50
Wednesday
$50

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Wanda Coach 4h 30m 3:30 PM Greenville, SC McDonald's 8:00 PM Durham, NC BP Guess Road  Economy $50
Wanda Coach 5h 15m 6:00 PM Greenville, SC McDonald's 11:15 PM Durham, NC BP Guess Road  Economy $50
Wanda Coach 4h 30m 9:30 PM Greenville, SC McDonald's 2:00 AM Durham, NC BP Guess Road  Economy $50
Wanda Coach 6h 30m 6:00 PM Greenville, SC McDonald's 12:30 AM Durham, NC BP Hillandale Rd  Economy $50
  • Did you know that if you travel from Greenville, SC to Durham, NC via Greensboro, NC, you can save more than $8? You can find the corresponding connections below.
    • FlixBus
      4h 55m
      0
      4:15 PM
      Greenville, SC
      Woodruff Rd
      8:10 PM
      Greensboro, NC
      Central bus station
      0
      FlixBus
      Economy
      $31
      • Waiting Time 0h 5m
    • FlixBus
      0h 55m
      0
      8:15 PM
      Greensboro, NC
      Central bus station
      9:10 PM
      Durham, NC
      Chapel Hill and Willard St
      0
      FlixBus
      Economy
      $11
    Travel time is 0h 25m longer, but you will save $8

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 4h 40m 12:55 PM Greenville, SC Woodruff Rd 5:35 PM Durham, NC Exxon  Economy $39
FlixBus 4h 55m 4:15 PM Greenville, SC Woodruff Rd 9:10 PM Durham, NC Exxon  Economy $39
Greyhound US 7h 0m 7:10 AM Greenville, SC Woodruff Rd 2:10 PM Durham, NC Exxon  Economy $45
Greyhound US 5h 35m 3:25 AM Greenville, SC Woodruff Rd 9:00 AM Durham, NC Exxon  Economy $49
Wanda Coach 4h 30m 3:30 PM Greenville, SC McDonald's 8:00 PM Durham, NC BP Hillandale Rd  Economy $50

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 4h 40m 12:55 PM Greenville, SC Woodruff Rd 5:35 PM Durham, NC Exxon  Economy $39
FlixBus 4h 55m 4:15 PM Greenville, SC Woodruff Rd 9:10 PM Durham, NC Exxon  Economy $39
Greyhound US 7h 0m 7:10 AM Greenville, SC Woodruff Rd 2:10 PM Durham, NC Exxon  Economy $45
Greyhound US 5h 35m 3:25 AM Greenville, SC Woodruff Rd 9:00 AM Durham, NC Exxon  Economy $49
Wanda Coach 4h 30m 3:30 PM Greenville, SC McDonald's 8:00 PM Durham, NC BP Hillandale Rd  Economy $50

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Wanda Coach 4h 30m 3:30 PM Greenville, SC McDonald's 8:00 PM Durham, NC BP Hillandale Rd  Economy $50
Wanda Coach 6h 30m 6:00 PM Greenville, SC McDonald's 12:30 AM Durham, NC BP Hillandale Rd  Economy $50
Wanda Coach 5h 15m 6:00 PM Greenville, SC McDonald's 11:15 PM Durham, NC BP Guess Road  Economy $50
Wanda Coach 4h 30m 9:30 PM Greenville, SC McDonald's 2:00 AM Durham, NC BP Guess Road  Economy $50
  • Did you know that if you travel from Greenville, SC to Durham, NC via Charlotte, you can save more than $8? You can find the corresponding connections below.
    • FlixBus
      4h 35m
      0
      9:35 PM
      Greenville, SC
      Woodruff Rd
      11:25 PM
      Charlotte
      W Trade St
      0
      FlixBus
      Economy
      $16
      • Waiting Time 0h 10m
    • FlixBus
      2h 35m
      0
      11:35 PM
      Charlotte
      W Trade St
      2:10 AM
      Durham, NC
      Exxon
      0
      FlixBus
      Economy
      $26
    Travel time is 0h 5m longer, but you will save $8

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Wanda Coach 4h 30m 3:30 PM Greenville, SC McDonald's 8:00 PM Durham, NC BP Guess Road  Economy $50
Wanda Coach 5h 15m 6:00 PM Greenville, SC McDonald's 11:15 PM Durham, NC BP Guess Road  Economy $50
Wanda Coach 4h 30m 9:30 PM Greenville, SC McDonald's 2:00 AM Durham, NC BP Guess Road  Economy $50
Wanda Coach 6h 30m 6:00 PM Greenville, SC McDonald's 12:30 AM Durham, NC BP Hillandale Rd  Economy $50
  • Did you know that if you travel from Greenville, SC to Durham, NC via Charlotte, you can save more than $8? You can find the corresponding connections below.
    • FlixBus
      4h 35m
      0
      9:35 PM
      Greenville, SC
      Woodruff Rd
      11:25 PM
      Charlotte
      W Trade St
      0
      FlixBus
      Economy
      $16
      • Waiting Time 0h 10m
    • FlixBus
      2h 35m
      0
      11:35 PM
      Charlotte
      W Trade St
      2:10 AM
      Durham, NC
      Exxon
      0
      FlixBus
      Economy
      $26
    Travel time is 0h 5m longer, but you will save $8

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Wanda Coach 4h 30m 3:30 PM Greenville, SC McDonald's 8:00 PM Durham, NC BP Hillandale Rd  Economy $50
Wanda Coach 6h 30m 6:00 PM Greenville, SC McDonald's 12:30 AM Durham, NC BP Hillandale Rd  Economy $50
Wanda Coach 5h 15m 6:00 PM Greenville, SC McDonald's 11:15 PM Durham, NC BP Guess Road  Economy $50
Wanda Coach 4h 30m 9:30 PM Greenville, SC McDonald's 2:00 AM Durham, NC BP Guess Road  Economy $50
  • Did you know that if you travel from Greenville, SC to Durham, NC via Charlotte, you can save more than $8? You can find the corresponding connections below.
    • FlixBus
      4h 35m
      0
      9:35 PM
      Greenville, SC
      Woodruff Rd
      11:25 PM
      Charlotte
      W Trade St
      0
      FlixBus
      Economy
      $16
      • Waiting Time 0h 10m
    • FlixBus
      2h 35m
      0
      11:35 PM
      Charlotte
      W Trade St
      2:10 AM
      Durham, NC
      Exxon
      0
      FlixBus
      Economy
      $26
    Travel time is 0h 5m longer, but you will save $8

Best Price Offer: The price for the cheapest bus from Greenville, SC to Durham, NC is $39 on 9/10/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Greenville, SC and Durham, NC

See here how frequent the connections between Greenville, SC and Durham, NC are, during different times and days of the week.
Friday is the busiest day, with more than 10 daily buses from Greenville, SC to Durham, NC. Sunday has instead the fewest connections, with only 5 daily coaches between Greenville, SC and Durham, NC.
The busiest time of the day is the Evening, with 20 buses from Greenville, SC to Durham, NC, while Morning sees the fewest connections between Greenville, SC and Durham, NC, with 2 offers.

Facts about the bus from Greenville, SC to Durham, NC

Compare all providers like Wanda Coach, FlixBus and Greyhound US that travel 6 times every day by bus from Greenville, SC to Durham, NC in one click! Book your bus ticket from Greenville, SC to Durham, NC starting from $39!

Cheapest Bus $39
Fastest Bus 4h 30m
Earliest Bus 3:30 PM
Latest Bus 9:30 PM
Daily Bus Routes 6 Ø
Distance 211.7 miles
Bus Companies Wanda Coach, FlixBus and Greyhound US

Cheapest bus connections from Greenville, SC to Durham, NC

Every day, 6 buses from 3 bus companies leave Greenville, SC for Durham, NC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 08/27/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 08/23
Monday 08/24
Tuesday 08/25
Wednesday 08/26
Thursday 08/27
$50
Friday 08/28
$50
Saturday 08/29
$50
Sunday 08/30
$50
Monday 08/31
Tuesday 09/01
$50
Wednesday 09/02
$50
Thursday 09/03
$50
Friday 09/04
$50
Saturday 09/05
$50
Sunday 09/06
$41
Monday 09/07
$50
Tuesday 09/08
$50
Wednesday 09/09
$50
Thursday 09/10
$39
Friday 09/11
$50
Saturday 09/12
$50
Sunday 09/13
$50
Monday 09/14
$50
Tuesday 09/15
$50
Wednesday 09/16
$50
Thursday 09/17
$50
Friday 09/18
$50
Saturday 09/19

The cheapest time to travel from Greenville, SC to Durham, NC

See here on which day and which time of the day you can find the cheapest bus ticket from Greenville, SC to Durham, NC, for the next 30 days.
With a price starting from $39, Thursday is the cheapest day for a bus from Greenville, SC to Durham, NC. Tuesday instead is the most expensive day with prices starting from $50.
Afternoon is the cheapest day time for bus tickets from Greenville, SC to Durham, NC, with $39. Morning is the most expensive time of the day with prices starting from $45.

How to save money travelling from Greenville, SC to Durham, NC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Greenville, SC to Durham, NC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Greenville, SC to Durham, NC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Greenville, SC to Durham, NC are also emptier.

All bus stations and stops in Greenville, SC and Durham, NC

In the map below, you can see where to find all bus stations in Greenville, SC and Durham, NC.

Service and Comfort on the bus from Greenville, SC to Durham, NC

Want to know which seat classes are available on the buses from Greenville, SC to Durham, NC? Or which bus companies serve the route Greenville, SC to Durham, NC? Below you will find answers to your questions.

FAQs about the Greenville, SC to Durham, NC bus

How much does a Greenville, SC Durham, NC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $39 and takes 4h 40m to reach Durham, NC. Compare offers to save money!

How much could I save by comparing buses from Greenville, SC to Durham, NC?

This route is offered by 3 companies with a range of ticket prices between $39 and $50. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Durham, NC.

On average, how many connections are available from Greenville, SC to Durham, NC each day?

Every day, the Greenville, SC to Durham, NC bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Greenville, SC to Durham, NC take?

The fastest bus from Greenville, SC to Durham, NC is offered by Wanda Coach and takes 4h 30m. Bus tickets for this connection cost $50. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Greenville, SC to Durham, NC?

The earliest bus arriving in Durham, NC from Greenville, SC starts at 3:30 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Greenville, SC to Durham, NC?

The latest bus trip departing from Greenville, SC for Durham, NC starts at 9:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Greenville, SC Durham, NC route?

When traveling by bus from Greenville, SC to Durham, NC, passengers can travel with Wanda Coach, FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Greenville, SC and Durham, NC?

You can check all the direct connections between Greenville, SC and Durham, NC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Wanda Coach, FlixBus and Greyhound US.

What can I take with me on the Greenville, SC to Durham, NC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Greenville, SC Durham, NC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Greenville, SC Durham, NC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Greenville, SC to Durham, NC on your planned travel date.

How does CheckMyBus find the best bus deals from Greenville, SC to Durham, NC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 6 daily trips between Greenville, SC and Durham, NC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Greenville, SC to Durham, NC?

Prices and availability for 6 trips between Greenville, SC and Durham, NC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Greenville, SC to Durham, NC

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Greenville, SC and to Durham, NC

Here’s an overview of the most popular bus routes to Greenville, SC and to Durham, NC. Simply click on the connection of your choice, and you will find all the details about your bus route!
Buses from Tucson, AZ to Greenville, SC Buses from Tucson, AZ to Greenville, SC
Buses Milwaukee to Greenville, SC Buses Milwaukee to Greenville, SC
Bus Las Vegas to Greenville, SC Bus Las Vegas to Greenville, SC
Buses to Greenville, SC from Lexington, KY Buses to Greenville, SC from Lexington, KY
Bus College Park, MD to Durham, NC Bus College Park, MD to Durham, NC
Bus Cincinnati to Durham, NC Bus Cincinnati to Durham, NC
From New Bern, NC to Durham, NC bus From New Bern, NC to Durham, NC bus
Buses to Durham, NC from St. Louis, MO Buses to Durham, NC from St. Louis, MO
Popular Airport Shuttles to Greenville, SC and to Durham, NC
CheckMyBus › Buses in USA › Bus to Greenville, SC › Bus to Durham, NC

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

offers,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

to

personalize

the

ads.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.