Bus Florence, SC to Orlando, FL - Compare all Companies

Compare all timetables for the bus from Florence, SC to Orlando, FL

Here is a selection of the cheapest bus trips from the schedule from Florence, SC to Orlando, FL from various bus operators like Greyhound US or FlixBus for the next days.

today

$69

tomorrow

$77

Monday

$68

Tuesday

$91

Wednesday

$71

Thursday

$70

Friday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	17h 40m	12:10 PM	Florence, SC	Bus Station	5:50 AM	Orlando, FL	Bus Station	Economy	$69	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 8/29/2026 12:10:00 PM to Bus Station, Orlando, FL (USA) arriving at 8/30/2026 5:50:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 17h 40m
Greyhound US	19h 40m	12:10 PM	Florence, SC	Bus Station	7:50 AM	Orlando, FL	Bus Station	Economy	$69	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 8/29/2026 12:10:00 PM to Bus Station, Orlando, FL (USA) arriving at 8/30/2026 7:50:00 AM. 50 Economy ticket for $69 per person are available. Travel duration is 19h 40m
Greyhound US	15h 40m	4:10 PM	Florence, SC	Bus Station	7:50 AM	Orlando, FL	Bus Station	Economy	$70	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 8/29/2026 4:10:00 PM to Bus Station, Orlando, FL (USA) arriving at 8/30/2026 7:50:00 AM. 50 Economy ticket for $70 per person are available. Travel duration is 15h 40m
Greyhound US	25h 55m	7:20 PM	Florence, SC	Bus Station	9:15 PM	Orlando, FL	Bus Station	Economy	$70	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 8/29/2026 7:20:00 PM to Bus Station, Orlando, FL (USA) arriving at 8/30/2026 9:15:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 25h 55m
Greyhound US	22h 45m	4:10 PM	Florence, SC	Bus Station	2:55 PM	Orlando, FL	Florida Mall	Economy	$70	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 8/29/2026 4:10:00 PM to Florida Mall, Orlando, FL (USA) arriving at 8/30/2026 2:55:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 22h 45m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	22h 45m	4:10 PM	Florence, SC	Bus Station	2:55 PM	Orlando, FL	Florida Mall	Economy	$77	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 8/30/2026 4:10:00 PM to Florida Mall, Orlando, FL (USA) arriving at 8/31/2026 2:55:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 22h 45m
Greyhound US	11h 45m	9:30 AM	Florence, SC	Bus Station	9:15 PM	Orlando, FL	Bus Station	Economy	$78	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 8/30/2026 9:30:00 AM to Bus Station, Orlando, FL (USA) arriving at 8/30/2026 9:15:00 PM. 50 Economy ticket for $78 per person are available. Travel duration is 11h 45m
Greyhound US	15h 40m	4:10 PM	Florence, SC	Bus Station	7:50 AM	Orlando, FL	Bus Station	Economy	$78	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 8/30/2026 4:10:00 PM to Bus Station, Orlando, FL (USA) arriving at 8/31/2026 7:50:00 AM. 50 Economy ticket for $78 per person are available. Travel duration is 15h 40m
Greyhound US	17h 40m	12:10 PM	Florence, SC	Bus Station	5:50 AM	Orlando, FL	Bus Station	Economy	$79	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 8/30/2026 12:10:00 PM to Bus Station, Orlando, FL (USA) arriving at 8/31/2026 5:50:00 AM. 50 Economy ticket for $79 per person are available. Travel duration is 17h 40m
Greyhound US	19h 40m	12:10 PM	Florence, SC	Bus Station	7:50 AM	Orlando, FL	Bus Station	Economy	$79	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 8/30/2026 12:10:00 PM to Bus Station, Orlando, FL (USA) arriving at 8/31/2026 7:50:00 AM. 50 Economy ticket for $79 per person are available. Travel duration is 19h 40m

Cheapest bus trips Monday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	8h 25m	5:45 AM	Florence, SC	TA Travel Center	2:10 PM	Orlando, FL	Bus Station		Economy	$68	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 8/31/2026 5:45:00 AM to Bus Station, Orlando, FL (USA) arriving at 8/31/2026 2:10:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 8h 25m

Cheapest bus trips Tuesday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	21h 10m	12:05 AM	Florence, SC	TA Travel Center	9:15 PM	Orlando, FL	Bus Station		Economy	$91	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/1/2026 12:05:00 AM to Bus Station, Orlando, FL (USA) arriving at 9/1/2026 9:15:00 PM. 50 Economy ticket for $91 per person are available. Travel duration is 21h 10m

Did you know that if you travel from Florence, SC to Orlando, FL via Jacksonville, FL, you can save more than $17? You can find the corresponding connections below.
- FlixBus
  
  18h 14m
  
  0
  
  5:45 AM
  
  Florence, SC
  TA Travel Center
  
  11:30 AM
  
  Jacksonville, FL
  Amtrak Train Station
  
  0
  
  Economy
  
  $49
  
  A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 8/30/2026 5:45:00 AM to Amtrak Train Station, Jacksonville, FL (USA) arriving at 8/30/2026 11:30:00 AM. 50 Economy ticket for $49 per person are available. Travel duration is 5h 45m
- FlixBus
  
  2h 49m
  
  0
  
  9:10 PM
  
  Jacksonville, FL
  Amtrak Train Station
  
  11:59 PM
  
  Orlando, FL
  Bus Station
  
  0
  
  Economy
  
  $25
  
  A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 8/30/2026 9:10:00 PM to Bus Station, Orlando, FL (USA) arriving at 8/30/2026 11:59:00 PM. 50 Economy ticket for $25 per person are available. Travel duration is 2h 49m
Travel Time is 2h 56m shorter, and you will save $17

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	17h 40m	12:10 PM	Florence, SC	Bus Station	5:50 AM	Orlando, FL	Bus Station	Economy	$71	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/2/2026 12:10:00 PM to Bus Station, Orlando, FL (USA) arriving at 9/3/2026 5:50:00 AM. 50 Economy ticket for $71 per person are available. Travel duration is 17h 40m
Greyhound US	22h 45m	4:10 PM	Florence, SC	Bus Station	2:55 PM	Orlando, FL	Florida Mall	Economy	$71	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/2/2026 4:10:00 PM to Florida Mall, Orlando, FL (USA) arriving at 9/3/2026 2:55:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 22h 45m
Greyhound US	25h 55m	7:20 PM	Florence, SC	Bus Station	9:15 PM	Orlando, FL	Bus Station	Economy	$72	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/2/2026 7:20:00 PM to Bus Station, Orlando, FL (USA) arriving at 9/3/2026 9:15:00 PM. 50 Economy ticket for $72 per person are available. Travel duration is 25h 55m
Greyhound US	19h 40m	12:10 PM	Florence, SC	Bus Station	7:50 AM	Orlando, FL	Bus Station	Economy	$103	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/2/2026 12:10:00 PM to Bus Station, Orlando, FL (USA) arriving at 9/3/2026 7:50:00 AM. 50 Economy ticket for $103 per person are available. Travel duration is 19h 40m
Greyhound US	15h 40m	4:10 PM	Florence, SC	Bus Station	7:50 AM	Orlando, FL	Bus Station	Economy	$104	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 9/2/2026 4:10:00 PM to Bus Station, Orlando, FL (USA) arriving at 9/3/2026 7:50:00 AM. 50 Economy ticket for $104 per person are available. Travel duration is 15h 40m

Cheapest bus trips Thursday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	8h 25m	5:45 AM	Florence, SC	TA Travel Center	2:10 PM	Orlando, FL	Bus Station		Economy	$70	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 9/3/2026 5:45:00 AM to Bus Station, Orlando, FL (USA) arriving at 9/3/2026 2:10:00 PM. 50 Economy ticket for $70 per person are available. Travel duration is 8h 25m

Best Price Offer: The price for the cheapest bus from Florence, SC to Orlando, FL is $55 on 8/24/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Florence, SC and Orlando, FL

See here how frequent the connections between Florence, SC and Orlando, FL are, during different times and days of the week.

Saturday is the busiest day, with more than 10 daily buses from Florence, SC to Orlando, FL. Monday has instead the fewest connections, with only 1 daily coaches between Florence, SC and Orlando, FL.

The busiest time of the day is the Afternoon, with 16 buses from Florence, SC to Orlando, FL, while Morning sees the fewest connections between Florence, SC and Orlando, FL, with 1 offers.

Facts about the bus from Florence, SC to Orlando, FL

Compare all providers like Greyhound US and FlixBus that travel 3 times every day by bus from Florence, SC to Orlando, FL in one click! Book your bus ticket from Florence, SC to Orlando, FL starting from $55!

Cheapest Bus	$55
Fastest Bus	8h 25m
Earliest Bus	12:10 PM
Latest Bus	5:45 AM
Daily Bus Routes	3 Ø
Distance	402.2 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Florence, SC to Orlando, FL

Every day, 3 buses from 2 bus companies leave Florence, SC for Orlando, FL: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 08/29/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 08/23

Monday 08/24

Tuesday 08/25

Wednesday 08/26

Thursday 08/27

Friday 08/28

Saturday 08/29

$62

Sunday 08/30

$64

Monday 08/31

$68

Tuesday 09/01

$91

Wednesday 09/02

$68

Thursday 09/03

$70

Friday 09/04

Saturday 09/05

$66

Sunday 09/06

Monday 09/07

$87

Tuesday 09/08

Wednesday 09/09

Thursday 09/10

Friday 09/11

$72

Saturday 09/12

$64

Sunday 09/13

Monday 09/14

$55

Tuesday 09/15

$83

Wednesday 09/16

Thursday 09/17

Friday 09/18

$62

Saturday 09/19

The cheapest time to travel from Florence, SC to Orlando, FL

See here on which day and which time of the day you can find the cheapest bus ticket from Florence, SC to Orlando, FL, for the next 30 days.

With a price starting from $55, Monday is the cheapest day for a bus from Florence, SC to Orlando, FL. Tuesday instead is the most expensive day with prices starting from $78.

Night is the cheapest day time for bus tickets from Florence, SC to Orlando, FL, with $55. Morning is the most expensive time of the day with prices starting from $77.

How to save money travelling from Florence, SC to Orlando, FL

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Florence, SC to Orlando, FL in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Florence, SC to Orlando, FL, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Florence, SC to Orlando, FL are also emptier.

Beloved bus companies from Florence, SC to Orlando, FL

These are the most booked bus companies between Florence, SC to Orlando, FL from our users.

Greyhound US from Florence, SC to Orlando, FL

Here you will find the key facts about the Greyhound US bus route Florence, SC to Orlando, FL:

Cheapest Price	$69
Fastest Bus	11h 45m
Earliest Bus	12:10 PM
Last Bus	7:20 PM
Daily Connections	6 Ø
Found on	8/2/2026

All bus stations and stops in Florence, SC and Orlando, FL

In the map below, you can see where to find all bus stations in Florence, SC and Orlando, FL.

Bus Station

S Irby St 611

TA Travel Center

W Lucas St 2301

Exxon Gas Station

W Lucas Street 1901

McDonalds

W. Lucas St. 1908

Shell Gas Station

W Lucas Street 1832

Bus Station

N John Young Pkwy 555

Florida Mall

Florida Mall Avenue 1602

RedCoach Station

Belle Isle

Universal Studio Orlando Resort

Universal Blvd 5800

Jet Set Express Orlando Terminal

L B McLeod Rd 3718

Service and Comfort on the bus from Florence, SC to Orlando, FL

Want to know which seat classes are available on the buses from Florence, SC to Orlando, FL? Or which bus companies serve the route Florence, SC to Orlando, FL? Below you will find answers to your questions.

FAQs about the Florence, SC to Orlando, FL bus

How much does a Florence, SC Orlando, FL bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $55 and takes 8h 25m to reach Orlando, FL. Compare offers to save money!

How much could I save by comparing buses from Florence, SC to Orlando, FL?

This route is offered by 2 companies with a range of ticket prices between $55 and $104. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Orlando, FL.

On average, how many connections are available from Florence, SC to Orlando, FL each day?

Every day, the Florence, SC to Orlando, FL bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Florence, SC to Orlando, FL take?

The fastest bus from Florence, SC to Orlando, FL is offered by FlixBus and takes 8h 25m. Bus tickets for this connection cost $68. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Florence, SC to Orlando, FL?

The earliest bus arriving in Orlando, FL from Florence, SC starts at 12:10 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Florence, SC to Orlando, FL?

The latest bus trip departing from Florence, SC for Orlando, FL starts at 5:45 AM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Florence, SC Orlando, FL route?

When traveling by bus from Florence, SC to Orlando, FL, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Florence, SC and Orlando, FL?

You can check all the direct connections between Florence, SC and Orlando, FL by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Florence, SC to Orlando, FL bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Florence, SC Orlando, FL bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Florence, SC Orlando, FL bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Florence, SC to Orlando, FL on your planned travel date.

How does CheckMyBus find the best bus deals from Florence, SC to Orlando, FL?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between Florence, SC and Orlando, FL. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Florence, SC to Orlando, FL?

Prices and availability for 3 trips between Florence, SC and Orlando, FL change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Florence, SC to Orlando, FL

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Florence, SC and to Orlando, FL

Here’s an overview of the most popular bus routes to Florence, SC and to Orlando, FL. Simply click on the connection of your choice, and you will find all the details about your bus route!