Which bus from Brussels to Prague is the cheapest?

Compare all bus companies and find the best price: Bus tickets from $49
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from Brussels to Prague

Here is a selection of the cheapest bus trips from the schedule from Brussels to Prague from various bus operators like FlixBus or European Sleeper for the next days.

today
$66
tomorrow
$68
Friday
$71
Saturday
$71
Sunday
$71
Monday
$72
Tuesday
$64

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 14h 40m 4:15 PM Brussels Midi Bus Station 6:55 AM Prague ÚAN Florenc  Economy $66
FlixBus 14h 5m 10:25 AM Brussels North Station 12:30 AM Prague Na Knížecí Station  Economy $68
FlixBus 14h 20m 10:25 AM Brussels North Station 12:45 AM Prague Wilsonova Bus Station  Economy $68
European Sleeper 16h 48m 6:06 PM Brussels Midi Bus Station 10:54 AM Prague Wilsonova Bus Station  Economy $321

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 14h 5m 10:25 AM Brussels North Station 12:30 AM Prague Na Knížecí Station  Economy $68
FlixBus 14h 20m 10:25 AM Brussels North Station 12:45 AM Prague Wilsonova Bus Station  Economy $68
FlixBus 13h 10m 8:20 AM Brussels North Station 9:30 PM Prague ÚAN Florenc  Economy $74
FlixBus 16h 35m 6:20 AM Brussels North Station 10:55 PM Prague Na Knížecí Station  Economy $77
FlixBus 15h 0m 10:30 PM Brussels Midi Bus Station 1:30 PM Prague ÚAN Florenc  Economy $79

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 14h 5m 10:25 AM Brussels North Station 12:30 AM Prague Na Knížecí Station  Economy $71
FlixBus 14h 20m 10:25 AM Brussels North Station 12:45 AM Prague Wilsonova Bus Station  Economy $71
FlixBus 14h 50m 6:30 PM Brussels North Station 9:20 AM Prague ÚAN Florenc  Economy $84
European Sleeper 16h 48m 6:06 PM Brussels Midi Bus Station 10:54 AM Prague Wilsonova Bus Station  Economy $183
  • Did you know that if you travel from Brussels to Prague via Cologne/Bonn Airport, you can save more than $12? You can find the corresponding connections below.
    • BlaBlaCar Bus
      15h 43m
      0
      2:05 PM
      Brussels
      Midi Bus Station
      5:50 PM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      0
      BlaBlaCar Bus
      Economy
      $20
      • Waiting Time 1h 50m
    • RegioJet
      10h 8m
      0
      7:40 PM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      4:48 AM
      Prague
      ÚAN Florenc
      0
      RegioJet
      Economy
      $39
    Travel time is 1h 38m longer, but you will save $12

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 14h 5m 10:25 AM Brussels North Station 12:30 AM Prague Na Knížecí Station  Economy $71
FlixBus 14h 20m 10:25 AM Brussels North Station 12:45 AM Prague Wilsonova Bus Station  Economy $71
FlixBus 14h 40m 4:15 PM Brussels Midi Bus Station 5:55 AM Prague ÚAN Florenc  Economy $74
FlixBus 15h 0m 10:30 PM Brussels Midi Bus Station 12:30 PM Prague ÚAN Florenc  Economy $74
FlixBus 15h 35m 6:30 PM Brussels North Station 9:05 AM Prague Na Knížecí Station  Economy $74
  • Did you know that if you travel from Brussels to Prague via Cologne/Bonn Airport, you can save more than $12? You can find the corresponding connections below.
    • BlaBlaCar Bus
      15h 43m
      0
      2:05 PM
      Brussels
      Midi Bus Station
      5:50 PM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      0
      BlaBlaCar Bus
      Economy
      $20
      • Waiting Time 1h 50m
    • RegioJet
      10h 8m
      0
      7:40 PM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      4:48 AM
      Prague
      ÚAN Florenc
      0
      RegioJet
      Economy
      $39
    Travel time is 2h 3m longer, but you will save $12

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 14h 5m 10:25 AM Brussels North Station 12:30 AM Prague Na Knížecí Station  Economy $71
FlixBus 14h 20m 10:25 AM Brussels North Station 12:45 AM Prague Wilsonova Bus Station  Economy $71
FlixBus 15h 0m 10:30 PM Brussels Midi Bus Station 1:30 PM Prague ÚAN Florenc  Economy $72
FlixBus 14h 40m 4:15 PM Brussels Midi Bus Station 6:55 AM Prague ÚAN Florenc  Economy $86
FlixBus 13h 10m 7:05 AM Brussels North Station 8:15 PM Prague ÚAN Florenc  Economy $86
  • Did you know that if you travel from Brussels to Prague via Saint-Gilles, you can save more than $26? You will find the corresponding connections below.
    • RegioJet
      Save more than 37%
      11h 55m
      Brussels
      1 mi
      6:30 PM
      Saint-Gilles
      Central Station
      6:25 AM
      Prague
      ÚAN Florenc
      0 mi
      RegioJet
      Economy
      $45
  • Did you know that if you travel from Brussels to Prague via Cologne/Bonn Airport, you can save more than $12? You can find the corresponding connections below.
    • BlaBlaCar Bus
      15h 43m
      0
      2:05 PM
      Brussels
      Midi Bus Station
      5:50 PM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      0
      BlaBlaCar Bus
      Economy
      $20
      • Waiting Time 1h 50m
    • RegioJet
      10h 8m
      0
      7:40 PM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      4:48 AM
      Prague
      ÚAN Florenc
      0
      RegioJet
      Economy
      $39
    Travel time is 2h 33m longer, but you will save $12

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 19h 5m 10:30 PM Brussels Midi Bus Station 5:35 PM Prague Hradčanská  Economy $72
FlixBus 15h 0m 10:30 PM Brussels Midi Bus Station 1:30 PM Prague ÚAN Florenc  Economy $72
FlixBus 15h 40m 9:30 PM Brussels North Station 1:10 PM Prague ÚAN Florenc  Economy $72
European Sleeper 16h 48m 6:06 PM Brussels Midi Bus Station 10:54 AM Prague Wilsonova Bus Station  Economy $282
  • Did you know that if you travel from Brussels to Prague via Cologne/Bonn Airport, you can save more than $17? You can find the corresponding connections below.
    • BlaBlaCar Bus
      18h 18m
      0
      10:30 AM
      Brussels
      Midi Bus Station
      2:25 PM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      0
      BlaBlaCar Bus
      Economy
      $16
      • Waiting Time 5h 15m
    • RegioJet
      9h 8m
      0
      7:40 PM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      4:48 AM
      Prague
      ÚAN Florenc
      0
      RegioJet
      Economy
      $39
    Travel time is 3h 18m longer, but you will save $17

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 15h 40m 9:30 PM Brussels North Station 1:10 PM Prague ÚAN Florenc  Economy $64
FlixBus 16h 30m 9:30 PM Brussels North Station 2:00 PM Prague Wilsonova Bus Station  Economy $64
FlixBus 17h 50m 4:15 PM Brussels Midi Bus Station 10:05 AM Prague Na Knížecí Station  Economy $65
FlixBus 15h 10m 6:00 AM Brussels North Station 9:10 PM Prague Na Knížecí Station  Economy $65
FlixBus 16h 35m 6:20 AM Brussels North Station 10:55 PM Prague Na Knížecí Station  Economy $65
  • Did you know that if you travel from Brussels to Prague via Cologne/Bonn Airport, you can save more than $9? You can find the corresponding connections below.
    • BlaBlaCar Bus
      18h 18m
      0
      10:30 AM
      Brussels
      Midi Bus Station
      2:25 PM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      0
      BlaBlaCar Bus
      Economy
      $16
      • Waiting Time 5h 15m
    • RegioJet
      9h 8m
      0
      7:40 PM
      Cologne/Bonn Airport
      Cologne/Bonn Airport - Bus Station
      4:48 AM
      Prague
      ÚAN Florenc
      0
      RegioJet
      Economy
      $39
    Travel time is 3h 8m longer, but you will save $9

Best Price Offer: The price for the cheapest bus from Brussels to Prague is $49 on 11/5/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Brussels and Prague

See here how frequent the connections between Brussels and Prague are, during different times and days of the week.
Friday is the busiest day, with more than 34 daily buses from Brussels to Prague. Thursday has instead the fewest connections, with only 30 daily coaches between Brussels and Prague.
The busiest time of the day is the Evening, with 97 buses from Brussels to Prague, while Night sees the fewest connections between Brussels and Prague, with 35 offers.

Facts about the bus from Brussels to Prague

Compare all providers like FlixBus and European Sleeper that travel 31 times every day by bus from Brussels to Prague in one click! Book your bus ticket from Brussels to Prague starting from $49!

Cheapest Bus $49
Fastest Bus 13h 10m
Earliest Bus 1:20 AM
Latest Bus 10:55 PM
Daily Bus Routes 31 Ø
Distance 446.6 miles
Bus Companies FlixBus and European Sleeper

Cheapest bus connections from Brussels to Prague

Every day, 31 buses from 2 bus companies leave Brussels for Prague: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 10/21/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 10/18
Monday 10/19
Tuesday 10/20
Wednesday 10/21
$66
Thursday 10/22
$68
Friday 10/23
$183
Saturday 10/24
$71
Sunday 10/25
$71
Monday 10/26
$212
Tuesday 10/27
$64
Wednesday 10/28
$66
Thursday 10/29
$107
Friday 10/30
$298
Saturday 10/31
$68
Sunday 11/01
$68
Monday 11/02
$62
Tuesday 11/03
$54
Wednesday 11/04
$55
Thursday 11/05
$49
Friday 11/06
$80
Saturday 11/07
$58
Sunday 11/08
$64
Monday 11/09
$54
Tuesday 11/10
$56
Wednesday 11/11
$58
Thursday 11/12
$61
Friday 11/13
$62
Saturday 11/14

The cheapest time to travel from Brussels to Prague

See here on which day and which time of the day you can find the cheapest bus ticket from Brussels to Prague, for the next 30 days.
With a price starting from $49, Thursday is the cheapest day for a bus from Brussels to Prague. Friday instead is the most expensive day with prices starting from $62.
Night is the cheapest day time for bus tickets from Brussels to Prague, with $49. Afternoon is the most expensive time of the day with prices starting from $65.

How to save money travelling from Brussels to Prague

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Brussels to Prague in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Brussels to Prague, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Brussels to Prague are also emptier.

Beloved bus companies from Brussels to Prague

These are the most booked bus companies between Brussels to Prague from our users.

FlixBus from Brussels to Prague

FlixBus

Here you will find the key facts about the FlixBus bus route Brussels to Prague:

Cheapest Price $64
Fastest Bus 13h 10m
Earliest Bus 1:20 AM
Last Bus 10:55 PM
Daily Connections 31 Ø
Found on 10/20/2026

All bus stations and stops in Brussels and Prague

In the map below, you can see where to find all bus stations in Brussels and Prague.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Brussels to Prague? Compare all modes of transports from Brussels to Prague.

Service and Comfort on the bus from Brussels to Prague

Want to know which seat classes are available on the buses from Brussels to Prague? Or which bus companies serve the route Brussels to Prague? Below you will find answers to your questions.

FAQs about the Brussels to Prague bus

How much does a Brussels Prague bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $49 and takes 15h 40m to reach Prague. Compare offers to save money!

How much could I save by comparing buses from Brussels to Prague?

This route is offered by 2 companies with a range of ticket prices between $49 and $321. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Prague.

On average, how many connections are available from Brussels to Prague each day?

Every day, the Brussels to Prague bus route is served by approximately 31 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Brussels to Prague take?

The fastest bus from Brussels to Prague is offered by FlixBus and takes 13h 10m. Bus tickets for this connection cost $79. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Brussels to Prague?

The earliest bus arriving in Prague from Brussels starts at 1:20 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Brussels to Prague?

The latest bus trip departing from Brussels for Prague starts at 10:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Brussels Prague route?

When traveling by bus from Brussels to Prague, passengers can travel with FlixBus and European Sleeper. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Brussels and Prague?

You can check all the direct connections between Brussels and Prague by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and European Sleeper.

What can I take with me on the Brussels to Prague bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Brussels Prague bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Brussels Prague bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Brussels to Prague on your planned travel date.

How does CheckMyBus find the best bus deals from Brussels to Prague?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 31 daily trips between Brussels and Prague. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Brussels to Prague?

Prices and availability for 31 trips between Brussels and Prague change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Brussels to Prague

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Brussels and to Prague

Here’s an overview of the most popular bus routes to Brussels and to Prague. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus Ivano-Frankivsk - Brussels Bus Ivano-Frankivsk - Brussels
Buses from Malmö to Brussels Buses from Malmö to Brussels
Bus Khmelnytskyi - Brussels Bus Khmelnytskyi - Brussels
Bus from Stockholm to Brussels Bus from Stockholm to Brussels
Buses from Montpellier to Prague Buses from Montpellier to Prague
Buses from Verona to Prague Buses from Verona to Prague
Buses Sumy - Prague Buses Sumy - Prague
Bus from Rome to Prague Bus from Rome to Prague
Popular Airport Shuttles to Brussels and to Prague
CheckMyBus › Buses in Belgium › Bus to Brussels › Bus to Prague

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

offers,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

to

personalize

the

ads.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.